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Protein Overview: Spn4-PJ

General Information:
Name(s) found: Spn4-PJ / FBpp0089208 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • The gene Serine protease inhibitor 4 is referred to in FlyBase by the symbol Dmel\Spn4 (CG9453, FBgn0028985). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:2763409..2766428. It has the cytological map location 42D6. There is experimental evidence that it has the molecular function</span>: serine-type endopeptidase inhibitor activity. There is experimental evidence that it is involved in the biological process</span>: negative regulation of peptide hormone processing; negative regulation of endopeptidase activity; negative regulation of protein maturation by peptide bond cleavage. 7 alleles are reported. The phenotype of these alleles is annotated with: cephalopharyngeal skeleton. It has 11 annotated transcripts and 11 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 374 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: negative regulation of protein maturation by peptide bond cleavage [IMP]
    negative regulation of peptide hormone processing [IMP]
    negative regulation of endopeptidase activity [IDA]
    Molecular Function: serine-type endopeptidase inhibitor activity [IDA][ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADAAHQEFA RRLALFSINV YGKLSGQKPG ENIVFSPFSI QTCAAMARLG AENETATQLD  60
   61 QGLGLASSDP EQIAHSFHQV LAAYQDSQIL RIANKIFVMD GYQLRQEFDQ LLSKQFLSAA 120
  121 QSVDFSKNVQ AAATINNWVE QRTNHLIKDL VPADVLNSES RLVLVNAIHF KGTWQHQFAK 180
  181 HLTRPDTFHL DGERTVQVPM MSLKERFRYA DLPALDAMAL ELPYKDSDLS MLIVLPNTKT 240
  241 GLPALEEKLR LTTLSQITQS LYETKVALKL PRFKAEFQVE LSEVFQKLGM SRMFSDQAEF 300
  301 GKMLQSPEPL KVSAIIHKAF IEVNEEGTEA AAATVWRVMA VAAFSRKHFI ANHPFAFYVK 360
  361 THYDLPIFTG RYLG

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..374] PSI-BLAST 94.30103 Plasminogen activator inhibitor-2


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle