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Protein Overview: FBpp0311964, mia...

General Information:
Name(s) found: FBpp0311964 [FlyBase]
mia-PB / FBpp0289286 [FlyBase]
mia-PA / FBpp0088355 [FlyBase]
Description(s) found:
Found 33 descriptions.
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  • type=protein; loc=3R:complement(1374109..1374910,1375315..1375484,1375545..1376342); ID=FBpp0311964; name=mia-PC; parent=FBgn0014342,FBtr0346136; dbxref=FlyBase:FBpp0311964,FlyBase_Annotation_IDs:CG10390-PC; MD5=4714292a9f2e1cb3d6fe1fd87c606a07; length=589; release=r5.56; species=Dmel; [FlyBase]
  • The gene meiosis I arrest is referred to in FlyBase by the symbol Dmel\mia (CG10390, FBgn0014342). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:1374047..1376889. It has the cytological map location 83B1. Based on sequence similarity, it is predicted to have molecular function</span>: general RNA polymerase II transcription factor activity. There is experimental evidence that it is involved in the biological process</span>: male meiosis I; spermatogenesis. 8 alleles are reported. The phenotypes of these alleles are annotated with: testis; spermatocyte. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • The gene meiosis I arrest is referred to in FlyBase by the symbol Dmel\mia (CG10390, FBgn0014342). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:1374047..1376889. It has the cytological map location 83B1. Based on sequence similarity, it is predicted to have molecular function</span>: general RNA polymerase II transcription factor activity. There is experimental evidence that it is involved in the biological process</span>: male meiosis I; spermatogenesis. 8 alleles are reported. The phenotypes of these alleles are annotated with: testis; spermatocyte. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 589 amino acids

    Gene Ontology:
    Cellular Component: transcription factor TFIID complex [ISS]
    nucleolus [IDA]
    Biological Process: spermatid development [TAS]
    spermatogenesis [IMP]
    male meiosis I [IMP]
    meiosis [TAS]
    transcription initiation from RNA polymerase II promoter [ISS]
    regulation of transcription factor activity [IEA]
    Molecular Function: transcription initiation factor activity [IEA]
    general RNA polymerase II transcription factor activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MWQFENKNAT KMKTSQNEMP DKDKSFRRHS LSPRSLSAIF FHSTGLHLDD GVAQWLSINV  60
   61 KEDITNLLNE AGKYMRRIRD RRLQLSHIQH AVRMHDDLCY DIFFRLVHCD DCKMPPSQKV 120
  121 LKTVREAVTA EKKDELLVSY PESVQESVPE PVPETSLEPP PMHTGWLKVE QVLLKPSKRY 180
  181 PLSMEQQNFF ELVTEACVGD LESRRVLALK AISTDPSLEE LLPRLTKFIA DAVAINVAQQ 240
  241 NLPLLLYLMR MVRALLGNQR FSLLQYLHLL LPAVLSCLLA KQVCASPNSE DHWALREYSG 300
  301 NIMAHIVRQF DAADNGILPR VIGVYNKALL KKPLTTVFGA VIGLGKMGNH AVRACILPQL 360
  361 KYLSEHIDSH MAASNDSPSS SVDRQAVKYI RHRLMKMCSP VLMGIHQPPD LPEEFMERYG 420
  421 SLGTLMSDGV TVMRTKKQAV AAAKAEAELK LKNMATEHLN SRGKGSRSVG SNDLVSGTQL 480
  481 PKNGIRPTSQ APKSVYSISV NGQTVKISTP NLCNTMLQHQ KKDLFSKPSD FVVPQLVVNQ 540
  541 FKNGLIPSNS QRSSSPARNV IHLKPNNDHP SKMALFLRQA ITADCPIIT

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..111] PSI-BLAST 20.0 TAF(II)62
    2 View Details [112..407] FFAS03 1.14 No description for 2of3A was found.
    3 View Details [408..589] MSA 87.140997 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • general RNA polymerase II transcription factor activity
    		•  9.25279783093877 bayes_pls_golite062009
  • DNA binding
    		•  4.24625687315724 bayes_pls_golite062009
  • transcription regulator activity
    		•  4.08606081850613 bayes_pls_golite062009
  • transcription initiation factor activity
    		•  3.96621818094279 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.93473976418251 bayes_pls_golite062009
  • binding
    		•  3.79827182235984 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.28941584139552 bayes_pls_golite062009
  • transcription factor activity
    		•  2.31114764804139 bayes_pls_golite062009
  • transcription activator activity
    		•  1.25487495162413 bayes_pls_golite062009
  • transcription factor binding
    		•  1.15204005455906 bayes_pls_golite062009
  • transcription coactivator activity
    		•  1.1297723528047 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  1.10331930589736 bayes_pls_golite062009
  • protein binding
    		•  1.10166468462827 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.01502031330902 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.72554769377984 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.0792897588268993 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.90

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle