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Protein Overview: sif-PC

General Information:
Name(s) found: sif-PC / FBpp0111622 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene still life is referred to in FlyBase by the symbol Dmel\sif (CG34418, FBgn0085447). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3L:5660920..5741139. It has the cytological map location 64E1-64E5. Based on sequence similarity, it is predicted to have molecular function</span>: Rho guanyl-nucleotide exchange factor activity. There is experimental evidence that it is involved in the biological process</span>: regulation of axonogenesis. 18 alleles are reported. The phenotype of these alleles is annotated with: bouton. It has 8 annotated transcripts and 8 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 2061 amino acids

    Gene Ontology:
    Cellular Component: synapse [NAS]
    intracellular [IEA]
    Biological Process: regulation of Rho protein signal transduction [IEA]
    regulation of axonogenesis [IGI]
    regulation of synapse structure and activity [TAS]
    synaptic transmission [NAS]
    actin cytoskeleton organization [NAS]
    Molecular Function: protein binding [IEA]
    guanyl-nucleotide exchange factor activity [NAS]
    receptor signaling protein activity [IEA]
    Rho guanyl-nucleotide exchange factor activity [IEA][ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEQKCIRRKG SVRLTEPTGH AHVRIEQRPQ LPPRRQKSAE EVATMPKSAL RQPPEQLEWF  60
   61 DRRAQQRHSA RSAEGGQVRE ETMEWLKLQK TASPIQPVRT SSGPSEITVL KDELPDWLLD 120
  121 HLPRKKERER DRLPSDADKA VGSAYAKALA DLLKKPLSRQ GSGPCEFSLL KTDIVEWLTK 180
  181 MQSSSGTDRG KSRRSHHRRN GSGGDAQPRS NSQEDAQDQS KTSHRKRHSL GHSGAVSEEE 240
  241 QQQLTADWIA YPLHKLQSLG KQPPPAQPPE RMSIPSGYAV PSALSHTPLC QRREERSRER 300
  301 RLRHSASEVV GSGGAGAAST SNTAHLERLY AKPHKERYQY VPKTKESSGR KERSRRHQTQ 360
  361 RSATVSDMSA QRSGGHKRKS SSAERAPRSP SPGPCTDPDC PLLPICTDPH CRYQECQARQ 420
  421 CITSSVSSVN LARHQQLAQV QLHAVPAHLV GAMGSDVPTT PSTTATPPPP TGGGTMGVGA 480
  481 TGAGAGATSE RRLVICHDCR SCAPLLSCRN RKCLNAAKCN SLPRCAADFN RLRTQLSQPP 540
  541 TTLDDIEPAP LDDLEMQPLP SPPHPHPHHH YRSNSQPNTL QRGDSASSAG MGAGVGGAGH 600
  601 GGLGGPGSGL AWLEPTTTLV QPLPAYVHHS NGKLMKSASA ASLNSRRRRH KTVHFGENLL 660
  661 REVCQNRKLI KTEAQVPSGS APMKANIQML YNFVEGVLSA WVDDDEDQVR SGAESEPEHG 720
  721 VVPMQPIHRC NRLRYQCIRR VVEEAADLQG TLKLGNSRYR HRHWRSTAKQ CNEMFLRKIS 780
  781 DDDRMSLTTA VSDEDDGESV MASPYKAKAT GTAASSFNCT GAVRKAGFLS VKKWLLRKKH 840
  841 QIELARKRGW KGYWVCLKGT TLLFYPCDSR EGRSVEAAPK HLIIVDGAIM QPIPEHPKRD 900
  901 YIFCLSTAFG DAYLFQAPCQ VELENWVNSI HSACAAAFAR HRGKTGTLHL LQEEIFRLEK 960
  961 AIESDHKLKH MAELQQSVVT DQETRHQIQT QILQWEENLE RLHCEQFRLR CYMASLQSGE1020
 1021 LPNPKSLLTH VSRPTKNTLN KLGVFTVSSF HAFICARSPS LLNNLLAGRG ATKRRPPMLS1080
 1081 RSNSGSSRRS MQMNSRDEPE KTFKVAMPDN AYSTVYLRDA MSVEEFLASA CARRNLNPME1140
 1141 HFVRVKKRRD MEDHNYFVPH RNDLIENYLH NHEFVEVCMK ILYQVELQRT TLEQMWGFSV1200
 1201 EAELIENAER QDELCCYVSR VEDKSVAMHN GIIKGDEIMV INGAIVSDLD MMYLESVLQE1260
 1261 EQSLSMMMRS SRTEPPDLVG IMRVTDDMID SLVCPPPPTD PPVMSEEMIT GLIVPAPGWN1320
 1321 GTSKDLYSPE AESSPATSFV DPAAMAAQLA VGGVGGVVVG GLGVAKPTSR TSSFEIENLL1380
 1381 KTAEQVTGFC RSPQETRKSS PTGSVTSSVS TTALTPSRQL TDAEKLRKVV MELVDTERTY1440
 1441 VKHLNNLLEH YLEPMKRETF LSNAEINALF GNIHEIVTFQ RQFLQNLEES LDLEPDFNKF1500
 1501 EHCGQFRNVL FAIGSAFLYY VNHFKLYSSF CASHSKAQKV LHPNEGNHAL QEFLAARNPK1560
 1561 QQHSSTLESY LIKPIQRILK YPLLLQQMRN LTDTRADEHV HLCEALKGME KVAEHINEMQ1620
 1621 RIHEEYGAIF DHLFRQHQKS CKQPIDLSPG DLLYYGGVEW LNISDFLGKI KKGLELHAMC1680
 1681 FVFKSAVVFL CKERLRQKKK LMGVSSKNAT NEVEIIRYQV LIPVTEVQVR ASSAKDMDSH1740
 1741 FLWELIHLRS QLQRRSEKVY VLSNSTADFR NAFLKTIRQI IRESVRNMSI PMKNFGGSSG1800
 1801 SVSGHSSQGM GSMGYPGNSQ TLERPKQQIT IVHGSHTLGK PKKKSGSQRH SAGNIDYDNL1860
 1861 SGSQEADDLP PSVGVVHYAS GHTHGQQMQP AGFRGRSKTV GDVTEITCSS PEPHQQQQQQ1920
 1921 QQQQQQLMQQ GHAHAHPHPH PHPREPPPPP IRQPHLHHHS SDIERIDPGT KSEGEEDSQQ1980
 1981 GTIRPKATLG RTPNHLTLST TSTLSVGSTG SQARLIQSSH PPASYQPVLM KDLGSPVWKP2040
 2041 RDMINLGTDP QSTTRKDDVK N

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.84

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle