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Protein Overview: AP-1gamma-PB

General Information:
Name(s) found: AP-1gamma-PB / FBpp0071230 [FlyBase]
Description(s) found:
Found 18 descriptions.
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  • The gene AP-1Ã?&#142;Ã?³ is referred to in FlyBase by the symbol Dmel\AP-1Ã?&#142;Ã?³ (CG9113, FBgn0030089). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:9002726..9011773. It has the cytological map location 8C9-8C10. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: protein binding; protein transporter activity. It is reported to be involved in the biological process</span>: vesicle coating; neurotransmitter secretion; synaptic vesicle coating. 3 alleles are reported. No phenotypic data is available. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 976 amino acids

    Gene Ontology:
    Cellular Component: synaptic vesicle [TAS]
    clathrin adaptor complex [IEA]
    Golgi apparatus part [IEA]
    coated vesicle [TAS]
    Biological Process: vesicle coating [TAS]
    vesicle-mediated transport [IEA]
    synaptic vesicle coating [TAS]
    intracellular protein transport [IEA]
    neurotransmitter secretion [NAS]
    Molecular Function: protein binding [IEA]
    protein transporter activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYPYYEQDWS VLPPENNRRF NPAFNMATIR QAFTEAVERV RMPTPTRLRD LIRQIRAART  60
   61 AAEERAVVNK ECAYIRSTFR EEDSVWRCRN IAKLLYIHML GYPAHFGQLE CLKLTASTRF 120
  121 TDKRIGYLGA MLLLDERQDV HLLITNCLKN DLNSSTQFVV GLALCTLGAI ASPEMARDLA 180
  181 SEVERLMKSP NTYIRKKATL CAFRVIRRVP ELMEIFLPAT RSLLSEKNHG ILITGVTLIT 240
  241 EMCENSSDTL MHFKKIVPNL VRILKNLILG GYSPEHDVSG VSDPFLQVKI LRLLRILGHN 300
  301 DPDASEAMND ILAQVATNTE TSKNVGNTIL YETVLSIMDI RSEGGLRVLA VNILGRFLLN 360
  361 SDKNIRYVAL NTLLRTVHAD TSAVQRHRTT ILECLKDPDV SIRRRAMELS FALINAQNIR 420
  421 TMTKELLLFL EKADAEFKAQ CSSGMILAAE RYSPTTRWHL DTQLSVLIAA GNYVRDDVVS 480
  481 STIQLVSSSP VPEQTYITNR FWESLQVANH CEDKQPLLQV AVWAIGEYGD LFMYGANEDE 540
  541 FERPTESDLI AVYYKFLTSA QVSTTSKQYA LVSLAKLSTR LQQCVEEIQA LITSFGSHLN 600
  601 VDLQQRGVEF TQLFGHYKHL RPPLLEKMPA MQISRISSQN GESGGGSFDD NSPDVIENGV 660
  661 EGGGGGGHSL IESNMNTLGD NTNILLDLLG STDLSAGGAG DLVAATDLSN AVHKKNSRNA 720
  721 NDVVAPVSNN QDLLDLLDLD LSAPSSTTTG APAGGGGGGG IVALVGDNNQ SSAANMNNML 780
  781 GGLDLGGFGS GLDSSASIPT NGNDLASMLG GLGAPPAASP SLAASAPVGN LIDGHAGSLL 840
  841 ADLNPTAASN NVVVPPQGPR LTALDKDGLL VQLVSVRGSD CMRIYMTTTN NSDNTLDQYL 900
  901 LQAAVQRSFQ LQMLTPSGSV LPPGGVITQE MRVVATSNAT LRMRLRIQYV LDGQQQVEQT 960
  961 EVSGFPEQQP APAAAE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..691] PSI-BLAST 152.0 AP1 clathrin adaptor core
    2 View Details [692..803] deduced N/A No confident structure predictions are available.
    3 View Details [804..976] PSI-BLAST 18.30103 Gamma1-adaptin domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • binding
    		•  1.73706375360191 bayes_pls_golite062009
  • protein binding
    		•  1.07977592306595 bayes_pls_golite062009
  • transporter activity
    		•  0.169557557237959 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.92

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle