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Protein Overview: TPH1

General Information:
Name(s) found: TPH1 [HGNC (HUGO)]
Description(s) found:
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  • gi|76826965|gb|AAI06740.1| Tryptophan hydroxylase 1 [Homo sapiens] [NCBI NR]
  • gi|4759248|ref|NP_004170.1| tryptophan hydroxylase 1 [Homo sapiens] [NCBI NR]
  • gi|37955|emb|CAA37018.1| unnamed protein product [Homo sapiens] [NCBI NR]
  • gi|119588828|gb|EAW68422.1| tryptophan hydroxylase 1 (tryptophan 5-monooxygenase), isoform CRA_b [Homo sapiens] [NCBI NR]
  • gi|119588827|gb|EAW68421.1| tryptophan hydroxylase 1 (tryptophan 5-monooxygenase), isoform CRA_b [Homo sapiens] [NCBI NR]
  • gi|116242823|sp|P17752.4|TPH1_HUMAN RecName: Full=Tryptophan 5-hydroxylase 1; AltName: Full=Tryptophan 5-monooxygenase 1 [NCBI NR]
  • pir||S10489 tryptophan 5-monooxygenase (EC 1.14.16.4) - human [NCBI NR]
  • tryptophan hydroxylase 1 [HGNC (HUGO)]
  • Tryptophan 5-hydroxylase 1 OS=Homo sapiens GN=TPH1 PE=1 SV=4 [Swiss-Prot]
  • tryptophan hydroxylase 1; tryptophan 5-monooxygenase [HMR_022704.fasta]
  • tryptophan hydroxylase 1; tryptophan 5-monooxygenase; tryptophan hydroxylase (tryptophan 5-monooxygenase) [071204_hmrz_cont.fasta]
  • tryptophan hydroxylase 1 [Homo sapiens]gi|107989|pir||S10489 tryptophan 5-monooxygenase (EC 1.14.16.4) - humangi|37955|emb|CAA37018.1| unnamed protein product [Homo sapiens] [nrdb_11152004_Chlamydomonas]
  • Tax_Id=9606 Tryptophan hydroxylase 1 [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_004179) tryptophan hydroxylase (tryptophan 5-monooxygenase) [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • tryptophan hydroxylase 1 [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • Tax_Id=9606 Hypothetical protein [EBI-IPI_human_3.12_11-03-2005_con_reversed.fasta]
  • tryptophan hydroxylase 1; tryptophan 5-monooxygenase; tryptophan hydroxylase (tryptophan 5-monooxygenase) [Homo sapiens] [HumanGallus06162005.fasta]
  • tryptophan hydroxylase 1; tryptophan 5-monooxygenase [Homo sapiens] [human-NCBI-042104-rand.fasta]
  • Tryptophan hydroxylase 1 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tryptophan 5-hydroxylase 1 (Tryptophan 5-monooxygenase 1) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • tryptophan hydroxylase 1 (tryptophan 5-monooxygenase), isoform CRA_b [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • unnamed protein product [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tryptophan hydroxylase 1 (tryptophan 5-monooxygenase) [Homo sapiens] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=9606 Isoform 1 of Tryptophan 5-hydroxylase 1 [EBI-IPI_human_3.23_11-02-2006_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=TPH1 Isoform 1 of Tryptophan 5-hydroxylase 1 [human-ipi-250309-contam.fasta]
  • IPI:IPI00016810.2|SWISS-PROT:P17752-1|TREMBL:B3VRW5;B3VRZ0;B3VRZ5;B3VS00;B3VS05;B3VS10;Q86WC5;Q86Y19;Q86Y20|ENSEMBL:ENSP00000250018|REFSEQ:NP_004170|H-INV:HIT000321798 Tax_Id=9606 Gene_Symbol=TPH1 Isoform 1 of Tryptophan 5-hydroxylase 1 [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • tryptophan 5-hydroxylase 1 [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • P17752;O95188;O95189;Q16736;Q3KPG8; RecName: Full=Tryptophan 5-hydroxylase 1; AltName: Full=Tryptophan 5-monooxygenase 1; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Isoform 1 of Tryptophan 5-hydroxylase 1 OS=Homo sapiens GN=TPH1 [011711_HMR.fasta]
  • IPI:IPI00016810.2|SWISS-PROT:P17752-1|TREMBL:B3VRW5;B3VRZ0;B3VRZ5;B3VS00;B3VS05;B3VS10;D3DQX6;Q86WC5;Q86Y19;Q86Y20|ENSEMBL:ENSP00000250018|REFSEQ:NP_004170|H-INV:HIT000321798 Tax_Id=9606 Gene_Symbol=TPH1 Isoform 1 of Tryptophan 5-hydroxylase 1 [ipi.HUMAN.fasta.20100406]
  • GeneSymbol=TPH1 Synonyms=MGC119994|TPRH|TRPH tryptophan 5-hydroxylase 1 [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00016810.2|SWISS-PROT:P17752-1|TREMBL:B3VRW5;B3VRZ0;B3VRZ5;B3VS00;B3VS05;B3VS10;Q86WC5;Q86Y19;Q86Y20|ENSEMBL:ENSP00000250018|REFSEQ:NP_004170|H-INV:HIT000321798|VEGA:OTTHUMP00000232851 Tax_Id=9606 Gene_Symbol=TPH1 Isoform 1 of Tryptophan 5-hydroxylase 1 [ipi.HUMAN.20110912.fasta]
  • Tryptophan 5-hydroxylase 1 GN=TPH1 [Doctor+uniprot-HUMAN-120911.fasta]
    • Organism: Homo sapiens
    Length: 444 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIEDNKENKD HSLERGRASL IFSLKNEVGG LIKALKIFQE KHVNLLHIES RKSKRRNSEF  60
   61 EIFVDCDINR EQLNDIFHLL KSHTNVLSVN LPDNFTLKED GMETVPWFPK KISDLDHCAN 120
  121 RVLMYGSELD ADHPGFKDNV YRKRRKYFAD LAMNYKHGDP IPKVEFTEEE IKTWGTVFQE 180
  181 LNKLYPTHAC REYLKNLPLL SKYCGYREDN IPQLEDVSNF LKERTGFSIR PVAGYLSPRD 240
  241 FLSGLAFRVF HCTQYVRHSS DPFYTPEPDT CHELLGHVPL LAEPSFAQFS QEIGLASLGA 300
  301 SEEAVQKLAT CYFFTVEFGL CKQDGQLRVF GAGLLSSISE LKHALSGHAK VKPFDPKITC 360
  361 KQECLITTFQ DVYFVSESFE DAKEKMREFT KTIKRPFGVK YNPYTRSIQI LKDTKSITSA 420
  421 MNELQHDLDV VSDALAKVSR KPSI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..95] PSI-BLAST 23.39794 No description for 2qmxA was found.
    2 View Details [96..444] PSI-BLAST 153.0 Tryptophan hydroxylase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • tyrosine 3-monooxygenase activity
    		•  10.4963678823868 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
    		•  10.3746889036269 bayes_pls_golite062009
  • phenylalanine 4-monooxygenase activity
    		•  5.13697132751033 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
    		•  4.1759203417536 bayes_pls_golite062009
  • monooxygenase activity
    		•  3.40046054657404 bayes_pls_golite062009
  • tryptophan 5-monooxygenase activity
    		•  3.21197226254744 bayes_pls_golite062009
  • oxidoreductase activity
    		•  2.09811280777991 bayes_pls_golite062009
  • binding
    		•  1.74682374387162 bayes_pls_golite062009
  • amine binding
    		•  1.23106204610034 bayes_pls_golite062009
  • catalytic activity
    		•  0.932947046865376 bayes_pls_golite062009
  • protein binding
    		•  0.431526081681418 bayes_pls_golite062009
  • tetrahydrobiopterin binding
    		•  0.0418066331050291 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle