Protein Overview: SUCLA2

General Information:
Name(s) found:	SUCLA2 [HGNC (HUGO)]
Description(s) found: Found 36 descriptions. SHOW ALL	succinate-CoA ligase, ADP-forming, beta subunit [HGNC (HUGO)]
Organism:	Homo sapiens
Length:	463 amino acids
Gene Ontology:
Cellular Component:	NONE FOUND
Biological Process:	NONE FOUND
Molecular Function:	NONE FOUND

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAASMFYGRL VAVATLRNHR PRTAQRAAAQ VLGSSGLFNN HGLQVQQQQQ RNLSLHEYMS  60
   61 MELLQEAGVS VPKGYVAKSP DEAYAIAKKL GSKDVVIKAQ VLAGGRGKGT FESGLKGGVK 120
  121 IVFSPEEAKA VSSQMIGKKL FTKQTGEKGR ICNQVLVCER KYPRREYYFA ITMERSFQGP 180
  181 VLIGSSHGGV NIEDVAAESP EAIIKEPIDI EEGIKKEQAL QLAQKMGFPP NIVESAAENM 240
  241 VKLYSLFLKY DATMIEINPM VEDSDGAVLC MDAKINFDSN SAYRQKKIFD LQDWTQEDER 300
  301 DKDAAKANLN YIGLDGNIGC LVNGAGLAMA TMDIIKLHGG TPANFLDVGG GATVHQVTEA 360
  361 FKLITSDKKV LAILVNIFGG IMRCDVIAQG IVMAVKDLEI KIPVVVRLQG TRVDDAKALI 420
  421 ADSGLKILAC DDLDEAARMV VKLSEIVTLA KQAHVDVKFQ LPI

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..54]	PSI-BLAST	41.69897	No description for 2gpsA was found.
2	View Details	[55..463]	PSI-BLAST	86.30103	Crystal structure of pig GTP-specific succinyl-CoA synthetase in complex with GTP

Functions predicted (by domain):

#

Gene Ontology predictions

1

No functions predicted.

2

Term	Confidence	Notes
succinate-CoA ligase (GDP-forming) activity	9.38156037766008	bayes_pls_golite062009
succinate-CoA ligase activity	9.37213380498009	bayes_pls_golite062009
CoA-ligase activity	8.19630272128785	bayes_pls_golite062009
acid-thiol ligase activity	7.98453115335343	bayes_pls_golite062009
succinate-CoA ligase (ADP-forming) activity	7.27105019329796	bayes_pls_golite062009
ligase activity, forming carbon-sulfur bonds	7.23103788464777	bayes_pls_golite062009
ligase activity	3.25077459445999	bayes_pls_golite062009
ATP citrate synthase activity	3.09252003125984	bayes_pls_golite062009
transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer	3.07329302783164	bayes_pls_golite062009
catalytic activity	2.5009559386228	bayes_pls_golite062009
CoA carboxylase activity	1.75094739650292	bayes_pls_golite062009
ligase activity, forming carbon-carbon bonds	1.59015373957506	bayes_pls_golite062009
acetyl-CoA carboxylase activity	1.29064883699349	bayes_pls_golite062009
transferase activity, transferring acyl groups	1.15639517822408	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	0.992008268375695	bayes_pls_golite062009
binding	0.346654244533873	bayes_pls_golite062009
biotin carboxylase activity	0.0172732430077291	bayes_pls_golite062009

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.73

Source: Reynolds et al. (2008)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle