Protein Overview: sir2

General Information:
Name(s) found:	sir2 / SPBC16D10.07c [Sanger Pombe]
Description(s) found: SHOW ONLY BEST	gi\|68012661\|ref\|NP_001018840.1\| Sir2 family histone deacetylase Sir2 [Schizosaccharomyces pombe 972h-] [NCBI NR] gi\|57015342\|sp\|O94640.2\|SIR2_SCHPO RecName: Full=NAD-dependent histone deacetylase sir2; AltName: Full=Silent information regulator 2; AltName: Full=Regulatory protein sir2 [NCBI NR] gi\|49457569\|emb\|CAG47122.1\| Sir2 family histone deacetylase Sir2 [Schizosaccharomyces pombe] [NCBI NR] Sir2 family histone deacetylase Sir2 [Sanger Pombe] NAD-dependent histone deacetylase sir2 OS=Schizosaccharomyces pombe GN=sir2 PE=1 SV=2 [Swiss-Prot] Transcriptional regulator; Sir2p family; histone deacetylase (PMID 12867036); NAD-dependent histone deacetylase (PMID 12867036); involved in transcriptional regulation (PMID 12867036); involved in chromatin silencing (PMID 12867036); involved in chromatin [4896.FASTAC] transcriptional regulator; Sir2p family; histone deacetylase (PMID 12867036); NAD-dependent histone deacetylase (PMID 12867036); involved in transcriptional regulation (PMID 12867036); involved in chromatin silencing (PMID 12867036); involved in chromatin [nrdb_11152004_Chlamydomonas] \|sir2\|\|Sir2p family histone deacetylase \|Schizosaccharomyces pombe\|chr 2\|\|\|Manual [pompep2242005.fasta] \|sir2\|\|Sir2 family histone deacetylase Sir2\|Schizosaccharomyces pombe\|chr 2\|\|\|Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta] SPBC16D10.07c [Schizosaccharomyces pombe] [nr-271106-contam.fasta] hypothetical protein SPBC16D10.07c [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta] NAD-dependent histone deacetylase sir2 (Regulatory protein sir2) (Silent information regulator 2) [nr-271106-contam.fasta] Sir2 family histone deacetylase Sir2 [Schizosaccharomyces pombe 972h-] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta] NAD-dependent histone deacetylase sir2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=sir2 PE=1 SV=2 [uniprot_sprot.fasta.20160308]
Organism:	Schizosaccharomyces pombe
Length:	475 amino acids
Gene Ontology:
Cellular Component:	mating-type region heterochromatin [IDA] chromosome, telomeric region [IDA] nucleus [IDA ] nuclear chromatin [IC] chromatin remodeling complex [ISS] chromosome, centromeric region [IDA]
Biological Process:	chromatin remodeling [ISS] chromatin silencing at centromere [IMP] regulation of histone H3-K9 methylation [IMP] chromosome segregation [IMP] chromatin silencing at silent mating-type cassette [IGI][IMP] histone deacetylation [IDA] chromatin silencing at telomere [IMP] replicative cell aging [ISS] cellular protein localization [IGI] regulation of nucleosome density [IEP] negative regulation of gene-specific transcription from RNA polymerase II promoter [IEP] regulation of transcription from RNA polymerase II promoter [IEP]
Molecular Function:	NAD-dependent histone deacetylase activity (H3-K9 specific) [IDA] zinc ion binding [IEA] NAD-dependent histone deacetylase activity (H4-K16 specific) [IDA] transcription regulator activity [IC] histone deacetylase activity (H3-K9 specific) [IDA] NAD binding [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASNPLDNNM PTTPVEEKIP VASYSPSSSG SSSGASLLVD IMCGSKETED EEVDSDEWDK  60
   61 PETENISDLD ERSEMVRYLR ASGYAKFLEK YLIEEELPVR SILKKLGINL PSALEEFEDI 120
  121 DLLPLLKEVL KREVARRIKL PHFNTFEDVV NLLKKAKNVV VLVGAGISTS LGILDFRSDN 180
  181 GFYARLARHG LSEPSEMFDI HTFRENPEIF YTFARDLLPE TNHYSPSHAF IRLLEKKNKL 240
  241 STLFTQNIDN LEKKTGLSDN KIIQCHGSFA TATCIKCKHK VDGSELYEDI RNQRVSYCNE 300
  301 CGKPPLKLRR VGQNKKEKHY FSDGDSESSE DDLAQPGIMK PDITFFGEAL PDSFFNKVGS 360
  361 GELEETDLLI CIGTSLKVAP VSELISVIPP TTPQIYISRT PVRHTQFDVN FLSPYCDWVI 420
  421 VEICKRAGWL NELQALCDLP ECHSGSKTRA FETDLDIKFE EPSTYHITST TNGSC

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.97

Protein Overview: sir2

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: