Protein Overview: rtGEF-PC

General Information:
Name(s) found:	rtGEF-PC / FBpp0111797 [FlyBase]
Description(s) found: SHOW ONLY BEST	gi\|161076972\|ref\|NP_001097184.1\| rho-type guanine exchange factor, isoform C [Drosophila melanogaster] [NCBI NR] gi\|157400189\|gb\|ABV53695.1\| rho-type guanine exchange factor, isoform C [Drosophila melanogaster] [NCBI NR] The gene rho-type guanine exchange factor is referred to in FlyBase by the symbol Dmel\rtGEF (CG10043, FBgn0015803). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2L:20350436..20365254. It has the cytological map location 38C5. Based on sequence similarity, it is predicted to have molecular function</span>: guanyl-nucleotide exchange factor activity. There is experimental evidence that it is involved in the biological process</span>: regulation of synapse organization. 12 alleles are reported. The phenotypes of these alleles are annotated with: t-bar; NMJ bouton; postsynaptic membrane; synaptic vesicle. It has 5 annotated transcripts and 5 annotated polypeptides. [FlyBase] type=protein; loc=2L:join(20355410..20355747,20355806..20356006,20356085..20356505,20356562..20356801,20356876..20359233,20360013..20360433,20360564..20360812,20364297..20364490); ID=FBpp0111797; name=rtGEF-PC; parent=FBgn0015803,FBtr0112884; dbxref=FlyBa [fly-100309-contam.fasta] type=protein; loc=2L:join(20355410..20355747,20355806..20356006,20356085..20356505,20356562..20356801,20356876..20359233,20360013..20360433,20360564..20360812,20364297..20364490); ID=FBpp0111797; name=rtGEF-PC; parent=FBgn0015803,FBtr0112884; dbxref=FlyBase:FBpp0111797,FlyBase_Annotation_IDs:CG10043-PC,REFSEQ:NP_001097184,GB_protein:ABV53695; MD5=cd58a17511b4f5245c05e00ad7555ac4; length=1473; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=2L:join(20355410..20355747,20355806..20356006,20356085..20356505,20356562..20356801,20356876..20359233,20360013..20360433,20360564..20360812,20364297..20364490); ID=FBpp0111797; name=rtGEF-PC; parent=FBgn0015803,FBtr0112884; dbxref=FlyBase:FBpp0111797,FlyBase_Annotation_IDs:CG10043-PC,REFSEQ:NP_001097184,GB_protein:ABV53695; MD5=cd58a17511b4f5245c05e00ad7555ac4; length=1473; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] Rho-type guanine exchange factor, isoform C OS=Drosophila melanogaster GN=rtGEF PE=4 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta] type=protein; loc=2L:join(20355410..20355747,20355806..20356006,20356085..20356505,20356562..20356801,20356876..20359233,20360013..20360433,20360564..20360812,20364297..20364490); ID=FBpp0111797; name=rtGEF-PC; parent=FBgn0015803,FBtr0112884; dbxref=FlyBase:FBpp0111797,FlyBase_Annotation_IDs:CG10043-PC,REFSEQ:NP_001097184,GB_protein:ABV53695,FlyMine:FBpp0111797,modMine:FBpp0111797; MD5=cd58a17511b4f5245c05e00ad7555ac4; length=1473; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
Organism:	Drosophila melanogaster
Length:	1473 amino acids
Gene Ontology:
Cellular Component:	intracellular [IEA]
Biological Process:	regulation of Rho protein signal transduction [IEA] regulation of synapse organization [IMP]
Molecular Function:	guanyl-nucleotide exchange factor activity [ISS] Rho guanyl-nucleotide exchange factor activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDQPLVVQAE YSFMGSNNDE LCFQKGDVIT VTQREDGGWW EGTLNDKTGW FPSNYVNECK  60
   61 VQLPLTETIR PPEEIQEYRS VVLKDLLDSE RAHVAELQGL LENFLEPMQQ TQILSQDEYA 120
  121 QLMCNFVEIV RTHEDLLIQI EECNDRVGKL FLTSAPLMKK VHQAYCAAHP KAIVILDKYK 180
  181 DELEKYMERQ GAATPGLLVL TTGLSKPFRR LDKYSAMLQE LERHMESSHP DRGDTQRSVA 240
  241 VYKDIAATCS ATRRQKELEL QVLTGPVRGW QGQELSTLGD IIHMGSVAVG ADHRDRYFVL 300
  301 FPQTLLFLSV SQRMSAFIYE GKLPLTGIIV NRLEDTDALK NAFEISSPLI DRIVAVCQGP 360
  361 NEANKWVELL NANNPSLPMG IKRQLSNLSN SSLGHLNAAH LSQHLDSRGY CTRFSLCAYY 420
  421 SSPPCHVRPL RVTLPPSNYP ATAPYANLSA HFARLVKGGG LRSAIVKMLL YPQARQSIDL 480
  481 KRIALRKRRC HKASAKLKDL NTNQDSGQSE LERQDAIELP TDSESYDDDF EDDFLHSCDS 540
  541 DPFEYVQFYQ NKRNDSMCNS TGTFVDHGTG ARRHCSSINL IKLDSADTDE VLALNELKKE 600
  601 SLVIGSRALR ALARKSTTRN SSVHTSTATL ELGVGGSITN CVEEEPILKV KPSFSLQQQS 660
  661 SDASSIFAAR LGGAFTACEN LASMPDDLSR ESSIQEPPTP LPASPTERHS MPTIFVGNRF 720
  721 NHSKNTEVYV PTWRDRQEMQ NQSVDAKQDE ELHSSSIDLP AACLSAPDKL QAELLYNYDE 780
  781 ILEKPLQLHR ELTPFPGHNL NSDKRVSHKS DSPSTGNAKT DPNLATRSSS TTELCIDTTS 840
  841 KKRTTPSERS RDSIRRCISY QFLQMSNRPP PPPPPRRDPD LHLDTKCRCC ENSQCPSPRS 900
  901 SDSGMAGSCT ITSPDPPNPE SYFPMEAAGH DMLDNVEPER FDVCGMFREK FLTPEATQDV 960
  961 VDLSEEQPQL SDEPTTPTNR KEEPTCITSA QVQVNTRSIF LPSSSSMDET NRNVPANNIL1020
 1021 FSSSSADQLE PQATFRSGMY AHWWKKERLP PEVVRGIAHA YNKSLPSKDS KDSGSVCSSC1080
 1081 FCSLGASGYS EGALYCSVCQ NCADYYNGSV TSTTNTTTTT SSASCPLCSE DEGMIAPTHD1140
 1141 SSSLDCPICN GRIASGAEEG KQSEMDRRPG NLRIPVEWYP VYLAGGMSPP SSHILLPPGG1200
 1201 RPPATPSSIP AGSSSGGSHS HQGSPATNSM SHHKRSQSFN HHLSYNQYTP TQPPPHHLHP1260
 1261 PQPPSLPSHL GASGPRSSSA QTPNSKTAAP LQASSMDASP AIQAAAAAAA AAVGMGVPSA1320
 1321 RKGSTKANWT ISCLRPTPPL RPSLLNATSG SGSGSGGSGG GGSSSSNALA SYCSGRKNQP1380
 1381 TYEEDALVLR VFEAYCAAYQ NNARNTIHSG LENEDMTPTL RQLWTAIRQM QQDMSQIKLQ1440
 1441 INEERALRAD LQQLLMQHLE TSSVSSGANT PKC

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.78

Protein Overview: rtGEF-PC

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: