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Protein Overview: PUUE_ECOLI, GOAG...

General Information:
Name(s) found: PUUE_ECOLI [Swiss-Prot]
GOAG_ECOLI [Swiss-Prot]
Description(s) found:
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  • pir||A64879 4-aminobutyrate transaminase (EC 2.6.1.19) goaG - Escherichia coli (strain K-12) [NCBI NR]
  • gi|1742132|dbj|BAA14871.1| GABA aminotransferase, PLP-dependent [Escherichia coli W3110] [NCBI NR]
  • gi|1708007|sp|P50457.1|PUUE_ECOLI RecName: Full=4-aminobutyrate aminotransferase; AltName: Full=Gamma-amino-N-butyrate transaminase; Short=GABA transaminase; AltName: Full=GABA aminotransferase; Short=GABA-AT; AltName: Full=Glutamate:succinic semialdehyde [NCBI NR]
  • gi|1054922|gb|AAC45301.1| GABA-aminotransferase [NCBI NR]
  • 4-aminobutyrate aminotransferase (EC 2.6.1.19) (Gamma-amino-N-butyrate transaminase) (GABA transaminase) (Glutamate:succinic semialdehyde transaminase) (GABA aminotransferase) (GABA-AT) - Escherichia coli [Swiss-Prot]
  • (P50457) 4-aminobutyrate aminotransferase (EC 2.6.1.19) (Gamma-amino-N-butyrate transaminase) (GABA transaminase) (Glutamate:succinic semialdehyde transaminase) (GABA aminotransferase) (GABA-AT) [Swiss-Prot]
  • 4-aminobutyrate aminotransferase; 4-aminobutyrate aminotransferase, PLP-dependent [Escherichia coli K12]gi|1787560|gb|AAC74384.1| 4-aminobutyrate aminotransferase; 4-aminobutyrate aminotransferase, PLP-dependent [Escherichia coli K12]gi|1054922|gb|AAC45 [nrdb_11152004_Chlamydomonas]
  • 4-aminobutyrate aminotransferase (Gamma-amino-N-butyrate transaminase) (GABA transaminase) (GABA aminotransferase) (GABA-AT) (Glutamate:succinic semialdehyde transaminase) [NCBI-RefSeq_human_na_08-09-2006_reversed.fasta]
  • GABA-aminotransferase [nr-271106-contam.fasta]
  • 4-aminobutyrate aminotransferase OS=Escherichia coli (strain K12) GN=puuE PE=3 SV=1 [uniprot-Ecoli-reviewed-110511.fasta]
  • 4-aminobutyrate aminotransferase PuuE OS=Escherichia coli (strain K12) GN=puuE PE=1 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Escherichia coli
    Length: 421 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNNEFHQRR LSATPRGVGV MCNFFAQSAE NATLKDVEGN EYIDFAAGIA VLNTGHRHPD  60
   61 LVAAVEQQLQ QFTHTAYQIV PYESYVTLAE KINALAPVSG QAKTAFFTTG AEAVENAVKI 120
  121 ARAHTGRPGV IAFSGGFHGR TYMTMALTGK VAPYKIGFGP FPGSVYHVPY PSDLHGISTQ 180
  181 DSLDAIERLF KSDIEAKQVA AIIFEPVQGE GGFNVAPKEL VAAIRRLCDE HGIVMIADEV 240
  241 QSGFARTGKL FAMDHYADKP DLMTMAKSLA GGMPLSGVVG NANIMDAPAP GGLGGTYAGN 300
  301 PLAVAAAHAV LNIIDKESLC ERANQLGQRL KNTLIDAKES VPAIAAVRGL GSMIAVEFND 360
  361 PQTGEPSAAI AQKIQQRALA QGLLLLTCGA YGNVIRFLYP LTIPDAQFDA AMKILQDALS 420
  421 D

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..421] PSI-BLAST 109.0 Structure of E. coli gamma-aminobutyrate aminotransferase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • 4-aminobutyrate transaminase activity
    		•  9.08769857759091 bayes_pls_golite062009
  • succinate-semialdehyde dehydrogenase binding
    		•  8.44659094913875 bayes_pls_golite062009
  • L-aspartate:2-oxoglutarate aminotransferase activity
    		•  3.359406422625 bayes_pls_golite062009
  • transferase activity
    		•  2.59075614411581 bayes_pls_golite062009
  • catalytic activity
    		•  2.29878871754893 bayes_pls_golite062009
  • 5-aminolevulinate synthase activity
    		•  1.85905571238884 bayes_pls_golite062009
  • adenosylmethionine-8-amino-7-oxononanoate transaminase activity
    		•  1.74778109525713 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor
    		•  1.46601963907552 bayes_pls_golite062009
  • glycine dehydrogenase (decarboxylating) activity
    		•  1.46601963907552 bayes_pls_golite062009
  • N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
    		•  1.4383564662931 bayes_pls_golite062009
  • transferase activity, transferring nitrogenous groups
    		•  1.28316822767388 bayes_pls_golite062009
  • transaminase activity
    		•  1.24990480711889 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  1.19150094103499 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.977210827616757 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.892872530648552 bayes_pls_golite062009
  • binding
    		•  0.892049641082766 bayes_pls_golite062009
  • ligase activity
    		•  0.827063849687833 bayes_pls_golite062009
  • DNA binding
    		•  0.803965264969424 bayes_pls_golite062009
  • kynureninase activity
    		•  0.777830972119923 bayes_pls_golite062009
  • carbon-sulfur lyase activity
    		•  0.698312655247044 bayes_pls_golite062009
  • intramolecular transferase activity, transferring amino groups
    		•  0.659071155545801 bayes_pls_golite062009
  • transcription factor activity
    		•  0.597417107954964 bayes_pls_golite062009
  • N-succinyltransferase activity
    		•  0.52897097514616 bayes_pls_golite062009
  • ornithine-oxo-acid transaminase activity
    		•  0.311107335626334 bayes_pls_golite062009
  • N-acyltransferase activity
    		•  0.2609065149092 bayes_pls_golite062009
  • pyridoxal phosphate binding
    		•  0.16957228630576 bayes_pls_golite062009
  • vitamin B6 binding
    		•  0.16957228630576 bayes_pls_golite062009
  • cystathionine beta-lyase activity
    		•  0.15938456446406 bayes_pls_golite062009
  • amine binding
    		•  0.14702601411039 bayes_pls_golite062009
  • methyltransferase activity
    		•  0.103986924428507 bayes_pls_golite062009
  • sulfurtransferase activity
    		•  0.0450490929307473 bayes_pls_golite062009
  • transferase activity, transferring one-carbon groups
    		•  0.0254276656964899 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.76

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle