Protein Overview: EGF_RAT

General Information:
Name(s) found:	EGF_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	pir\|\|EGRT epidermal growth factor precursor - rat [NCBI NR] gi\|6978797\|ref\|NP_036974.1\| epidermal growth factor [Rattus norvegicus] [NCBI NR] gi\|440237\|gb\|AAB60436.1\| preproepidermal growth factor [NCBI NR] gi\|1352360\|sp\|P07522.2\|EGF_RAT RecName: Full=Pro-epidermal growth factor; Short=EGF; Contains: RecName: Full=Epidermal growth factor; Flags: Precursor [NCBI NR] Pro-epidermal growth factor OS=Rattus norvegicus GN=Egf PE=1 SV=2 [Swiss-Prot] epidermal growth factor [HMR_022704-rand.fasta] epidermal growth factor [Rattus norvegicus]gi\|1352360\|sp\|P07522\|EGF_RAT Pro-epidermal growth factor precursor (EGF) [Contains: Epidermal growth factor]gi\|7428565\|pir\|\|EGRT epidermal growth factor precursor - ratgi\|440237\|gb\|AAB60436.1\| preproepidermal [nrdb_11152004_Chlamydomonas] Tax_Id=10116 Pro-epidermal growth factor precursor [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] (NM_012842) epidermal growth factor [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] Pro-epidermal growth factor precursor (EGF) [Contains: Epidermal growth factor] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] epidermal growth factor [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] preproepidermal growth factor [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 Gene_Symbol=Egf Pro-epidermal growth factor [rat-ipi-250309-contam.fasta] epidermal growth factor precursor [Rattus norvegicus] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta] Pro-epidermal growth factor OS=Rattus norvegicus GN=Egf [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	1133 amino acids
Gene Ontology:
Cellular Component:	platelet alpha granule lumen [UNKNOWN] extracellular space [UNKNOWN][IEA] soluble fraction [IDA] membrane [IEA] integral to membrane [IEA] extracellular region [UNKNOWN]
Biological Process:	positive regulation of phosphorylation [UNKNOWN][IEA] positive regulation of MAP kinase activity [UNKNOWN][IEA] peptidyl-tyrosine phosphorylation [UNKNOWN] regulation of protein secretion [IMP] signal transduction [UNKNOWN] epidermal growth factor receptor signaling pathway [UNKNOWN][IDA] positive regulation of cell proliferation [UNKNOWN] positive regulation of granule cell precursor proliferation [UNKNOWN][IEA] intracellular protein kinase cascade [TAS] positive regulation of epidermal growth factor receptor activity [UNKNOWN][IEA] positive regulation of mitosis [UNKNOWN][IEA] branching morphogenesis of a tube [UNKNOWN][IEA] negative regulation of secretion [UNKNOWN][IEA] regulation of peptidyl-tyrosine phosphorylation [UNKNOWN][IEA] activation of MAPKK activity [UNKNOWN][IEA] mammary gland alveolus development [UNKNOWN][IEA] angiogenesis [UNKNOWN][IEA]
Molecular Function:	growth factor activity [UNKNOWN][IEA] protein binding [UNKNOWN][IEA] calcium ion binding [IEA] epidermal growth factor receptor binding [UNKNOWN][IDA][TAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLFSLTFLSV FLKITVLSVT AQQTRNCQSG PLERSGTTTY AAAGPPRFLI FLQGNSIFRI  60
   61 NTDGTNHQQL VVDAGVSVVM DFHYKEERLY WVDLERQLLQ RVFFNGSGQE TVCKVDKNVS 120
  121 GLAINWIDGE ILRTDRWKGV ITVTDMNGNN SRVLLSSLKR PANILVDPTE RLIFWSSVVT 180
  181 GNLHRADLGG MDVKTLLEAP ERISVLILDI LDKRLFWAQD GREGSHGYIH SCDYNGGSIH 240
  241 HIRHQARHDL LTMAIFGDKI LYSALKEKAI WIADKHTGKN VVRVNLDPAS VPPRELRVVH 300
  301 LHAQPGTENR AQASDSERCK QRRGQCLYSL SERDPNSDSS ACAEGYTLSR DRKYCEDVNE 360
  361 CALQNHGCTL GCENIPGSYY CTCPTGFVLL PDGKRCHELV ACPGNRSECS HDCILTSDGP 420
  421 LCICPAGSVL GKDGKTCTGC SFSDNGGCSQ ICLPLSLASW ECDCFPGYDL QLDRKSCAAS 480
  481 MGPQPFLLFA NSQDIRHMHF DGTDYKTLLS RQMGMVFALD YDPVESKIYF AQTALKWIER 540
  541 ANLDGSQRER RITEGVDTPE GLAVDWIGRR IYWTDSGKSV IEGSDLSGKH HQIIIKESIS 600
  601 RPRGIAVHPK ARRLFWTDTG MSPRIESSSL QGSDRTLIAS SNLLEPSGIA IDYLTDTLYW 660
  661 CDTKLSVIEM ADLDGSKRRR LTQNDVGHPF SLAVFEDHVW FSDWAIPSVI RVNKRTGQNR 720
  721 VRLRGSMLKP SSLVVVHPLA KPGADPCLHR NGGCEHICQE SLGTAQCLCR EGFVKAPDGK 780
  781 MCLTRKDDQI LAGDNADLSK EVASLDNSPK AYVPDDDRTE SSTLVAEIMV SGLNYEDDCG 840
  841 PGGCGSHAHC ISEGEAAVCQ CLKGFAGDGN LCSDIDECEL GSSDCPPTSS RCINTEGGYV 900
  901 CQCSEGYEGD GIYCLDVDEC QQGSHGCSEN ATCTNTEGGY NCTCAGCPSA PGLPCPDSTS 960
  961 PSLLGKDGCH WVRNSNTGCP PSYDGYCLNG GVCMYVESVD RYVCNCVIGY IGERCQHRDL1020
 1021 RWWKLRHADY GQRHDITVVS VCVVALALLL LLGMWGTYYY RTRKQLSESS KKPSEESSSN1080
 1081 VSSNGPDSSG AGVSSGPQPW FVVLEEHQQP KNGRLPAAGT NGAVVEAGLS SSL

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: EGF_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: