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Protein Overview: asp-PA

General Information:
Name(s) found: asp-PA / FBpp0084071 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • The gene abnormal spindle is referred to in FlyBase by the symbol Dmel\asp (CG6875, FBgn0000140). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:20579625..20586235. It has the cytological map location 96A19-96A20. There is experimental evidence that it has the molecular function</span>: microtubule binding; SUMO binding; myosin light chain binding; protein kinase activity. There is experimental evidence for 12 unique biological process</span> terms, many of which group under: reproductive process in a multicellular organism; cell cycle; organelle organization; cell cycle process; multicellular organism reproduction; anatomical structure development; microtubule cytoskeleton organization; cell division; gamete generation; cellular localization. 21 alleles are reported. The phenotypes of these alleles are annotated with 21 unique terms, many of which group under: organ system; cytoplasmic part; anatomical structure; female germline cyst; nervous system; intracellular organelle part; peripheral nervous system; male germline cyst; cytoskeletal part; cell component. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1954 amino acids

    Gene Ontology:
    Cellular Component: microtubule organizing center [IDA]
    spindle pole [IDA]
    microtubule associated complex [IDA][ISS][NAS]
    Biological Process: cystoblast division [IMP]
    spindle organization [IMP]
    mitotic spindle organization [IMP]
    microtubule cytoskeleton organization [IDA]
    microtubule-based process [ISS]
    ovarian fusome organization [IMP]
    centrosome localization [IMP]
    female germ-line stem cell division [IMP]
    oogenesis [IMP]
    establishment of meiotic spindle localization [IMP]
    kinetochore organization [IMP]
    germarium-derived oocyte differentiation [IMP]
    actin filament reorganization involved in cell cycle [IMP]
    Molecular Function: SUMO binding [IPI]
    protein kinase activity [IDA]
    myosin light chain binding [IPI][RCA]
    microtubule binding [IDA][ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAFEITVTP SRLKQKKRAE GREPAVVVMA PFSAKAIVQF EDVPITKTAR RQVRVLNPSD  60
   61 DDIEVKVMKA IREEHNLSLE WMEHTVPARD EVSMELVWSP VLEVACKETL QLIDNRNFRK 120
  121 EVMIILKSKS NQPVKNPRKF PTVGKTLQLK SPTGAGKTMK SVVSAAVQQK KRMSAAAAPP 180
  181 SKQTWRVTAP SRPAAWAHPP PQAPLVEKNV YKTPQEEPVY ISPQPRSLKE NLSPMTPGNL 240
  241 LDVIDNLRFT PLTETRGKGQ ATIFPDNLAA WPTPTLKGNV KSCANDMRPR RITPDDLEDQ 300
  301 PATNKTFDVK HSETINISLD TLDCSRIDGQ PHTPLNKTTT IVHATHTRAL ACIHEEEGPS 360
  361 PPRTPTKSAI HDLKRDIKLV GSPLRKYSES MKDLSLLSPQ TKYAIQGSMP NLNEMKIRSI 420
  421 EQNRYYQEQQ IQIKAKDLNS SSSSEASLAG QQEFLFNHSE ILAQSSRFNL HEVGRKSVKG 480
  481 SPVKNPHKRR SHELSFSDAP SNESLYRNET VAISPPKKQR VEDTTLPRSA APANASARSS 540
  541 SAHAWPHAQS KKFKLAQTMS LMKKPATPRK VRDTSIQPSV KLYDSELYMQ TCINPDPFAA 600
  601 TTTIDPFLAS TMYLDEQAVD RHQADFKKWL NALVSIPADL DADLNNKIDV GKLFNEVRNK 660
  661 ELVVAPTKEE QSMNYLTKYR LETLRKAAVE LFFSEQMRLP CSKVAVYVNK QALRIRSDRN 720
  721 LHLDVVMQRT ILELLLCFNP LWLRLGLEVV FGEKIQMQSN RDIVGLSTFI LNRLFRNKCE 780
  781 EQRYSKAYTL TEEYAETIKK HSLQKILFLL LFLDQAKQKR IVKHNPCLFV KKSPHKETKD 840
  841 ILLRFSSELL ANIGDITREL RRLGYVLQHR QTFLDEFDYA FNNLAVDLRD GVRLTRVMEV 900
  901 ILLRDDLTRQ LRVPAISRLQ RIFNVKLALG ALGEANFQLG GDIAAQDIVD GHREKTLSLL 960
  961 WQLIYKFRSP KFHAAATVLQ KWWRRHWLHV VIQRRIRHKE LMRRHRAATV IQAVFRGHQM1020
 1021 RKYVKLFKTE RTQAAIILQK FTRRYLAQKQ LYQSYHSIIT IQRWWRAQQL GRQHRQRFVE1080
 1081 LREAAIFLQR IWRRRLFAKK LLAAAETARL QRSQKQQAAA SYIQMQWRSY QLGRIQRQQF1140
 1141 LRQRDLIMFV QRRMRSKWSM LEQRKEFQQL KRAAINIQQR WRAKLSMRKC NADYLALRSS1200
 1201 VLKVQAYRKA TIQMRIDRNH YYSLRKNVIC LQQRLRAIMK MREQRENYLR LRNASILVQK1260
 1261 RYRMRQQMIQ DRNAYLRTRK CIINVQRRWR ATLQMRRERK NYLHLQTTTK RIQIKFRAKR1320
 1321 EMKKQRAEFL QLKKVTLVVQ KRRRALLQMR KERQEYLHLR EVTIKLQRRF HAQKSMRFMR1380
 1381 AKYRGTQAAV SCLQMHWRNH LLRKRERNSF LQLRQAAITL QRRYRARLNM IKQLKSYAQL1440
 1441 KQAAITIQTR YRAKKAMQKQ VVLYQKQREA IIKVQRRYRG NLEMRKQIEV YQKQRQAVIR1500
 1501 LQKWWRSIRD MRLCKAGYRR IRLSSLSIQR KWRATVQARR QREIFLSTIR KVRLMQAFIR1560
 1561 ATLLMRQQRR EFEMKRRAAV VIQRRFRARC AMLKARQDYQ LIQSSVILVQ RKFRANRSMK1620
 1621 QARQEFVQLR TIAVHLQQKF RGKRLMIEQR NCFQLLRCSM PGFQARARGF MARKRFQALM1680
 1681 TPEMMDLIRQ KRAAKVIQRY WRGYLIRRRQ KHQGLLDIRK RIAQLRQEAK AVNSVRCKVQ1740
 1741 EAVRFLRGRF IASDALAVLS RLDRLSRTVP HLLMWCSEFM STFCYGIMAQ AIRSEVDKQL1800
 1801 IERCSRIILN LARYNSTTVN TFQEGGLVTI AQMLLRWCDK DSEIFNTLCT LIWVFAHCPK1860
 1861 KRKIIHDYMT NPEAIYMVRE TKKLVARKEK MKQNARKPPP MTSGRYKSQK INFTPCSLPS1920
 1921 LEPDFGIIRY SPYTFISSVY AFDTILCKLQ IDMF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..128] FFAS03 2.0 No description for 2e6jA was found.
    2 View Details [129..247] deduced N/A No confident structure predictions are available.
    3 View Details [248..407] MSA 3.154997 View MSA. No confident structure predictions are available.
    4 View Details [408..572] MSA 1.14698 View MSA. No confident structure predictions are available.
    5 View Details [573..648] deduced N/A No confident structure predictions are available.
    6 View Details [649..817] PSI-BLAST 7.154902 No description for 2fxmA was found.
    7 View Details [818..995] PSI-BLAST 5.0 Tropomyosin
    8 View Details [996..1373] PSI-BLAST 25.0 Heavy meromyosin subfragment
    9 View Details [1374..1447] FFAS03 2.41 No description for 2ix7C was found.
    10 View Details [1448..1571] deduced N/A No confident structure predictions are available.
    11 View Details [1572..1954] PSI-BLAST 9.30103 No description for 2dfsA was found.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.83

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
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