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Protein Overview: ALKH_ECOLI

General Information:
Name(s) found: ALKH_ECOLI [Swiss-Prot]
Description(s) found:
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  • gi|71152734|sp|P0A955.1|ALKH_ECOLI RecName: Full=KHG/KDPG aldolase; Includes: RecName: Full=4-hydroxy-2-oxoglutarate aldolase; AltName: Full=2-keto-4-hydroxyglutarate aldolase; Short=KHG-aldolase; Includes: RecName: Full=2-dehydro-3-deoxy-phosphogluconate [NCBI NR]
  • pir||ADECOG 2-dehydro-3-deoxy-phosphogluconate aldolase (EC 4.1.2.14) - Escherichia coli (strain K-12) [NCBI NR]
  • gi|41689|emb|CAA48732.1| 4-hydroxy-2-oxoglutarate aldolase [Escherichia coli] [NCBI NR]
  • gi|395404|emb|CAA45222.1| phospho-2-dehydro-3-deoxygluconate aldolase [Escherichia coli] [NCBI NR]
  • gi|304888|gb|AAA23862.1| 2-keto-3-deoxy-6-phosphogluconate aldolase [Escherichia coli] [NCBI NR]
  • pir||D85797 KHG-KDPG bifunctional aldolase [similarity] - Escherichia coli (strain O157:H7, substrain EDL933) [NCBI NR]
  • pir||H90948 KHG-KDPG bifunctional aldolase [similarity] - Escherichia coli (strain O157:H7, substrain RIMD 0509952) [NCBI NR]
  • gi|209767586|gb|ACI82105.1| 2-keto-3-deoxygluconate 6-phosphate aldolase/2-keto-4-hydroxyglutarate aldolase [Escherichia coli] [NCBI NR]
  • gi|209767584|gb|ACI82104.1| 2-keto-3-deoxygluconate 6-phosphate aldolase/2-keto-4-hydroxyglutarate aldolase [Escherichia coli] [NCBI NR]
  • gi|209767582|gb|ACI82103.1| 2-keto-3-deoxygluconate 6-phosphate aldolase/2-keto-4-hydroxyglutarate aldolase [Escherichia coli] [NCBI NR]
  • gi|209767580|gb|ACI82102.1| 2-keto-3-deoxygluconate 6-phosphate aldolase/2-keto-4-hydroxyglutarate aldolase [Escherichia coli] [NCBI NR]
  • gi|209767578|gb|ACI82101.1| 2-keto-3-deoxygluconate 6-phosphate aldolase/2-keto-4-hydroxyglutarate aldolase [Escherichia coli] [NCBI NR]
  • gi|1736493|dbj|BAA15658.1| multifunctional 2-keto-3-deoxygluconate 6-phosphate aldolase, 2-keto-4-hydroxyglutarate aldolase, and oxaloacetate decarboxylase [Escherichia coli W3110] [NCBI NR]
  • gi|145827|gb|AAA23723.1| KDPG aldolase [NCBI NR]
  • gi|13096119|pdb|1EUN|C Chain C, Structure Of 2-Keto-3-Deoxy-6-Phosphogluconate Aldolase From Escherichia Coli [NCBI NR]
  • gi|13096118|pdb|1EUN|B Chain B, Structure Of 2-Keto-3-Deoxy-6-Phosphogluconate Aldolase From Escherichia Coli [NCBI NR]
  • gi|13096117|pdb|1EUN|A Chain A, Structure Of 2-Keto-3-Deoxy-6-Phosphogluconate Aldolase From Escherichia Coli [NCBI NR]
  • gi|13096116|pdb|1EUA|C Chain C, Schiff Base Intermediate In Kdpg Aldolase From Escherichia Coli [NCBI NR]
  • gi|13096115|pdb|1EUA|B Chain B, Schiff Base Intermediate In Kdpg Aldolase From Escherichia Coli [NCBI NR]
  • gi|13096114|pdb|1EUA|A Chain A, Schiff Base Intermediate In Kdpg Aldolase From Escherichia Coli [NCBI NR]
  • gi|10835438|pdb|1FQ0|C Chain C, Kdpg Aldolase From Escherichia Coli [NCBI NR]
  • gi|10835437|pdb|1FQ0|B Chain B, Kdpg Aldolase From Escherichia Coli [NCBI NR]
  • gi|10835436|pdb|1FQ0|A Chain A, Kdpg Aldolase From Escherichia Coli [NCBI NR]
  • KHG/KDPG aldolase [Includes: 4-hydroxy-2-oxoglutarate aldolase (EC 4.1.3.16) (2-keto-4-hydroxyglutarate aldolase) (KHG-aldolase); 2-dehydro-3-deoxy-phosphogluconate aldolase (EC 4.1.2.14) (Phospho-2-dehydro-3-deoxygluconate aldolase) (Phospho-2-keto-3-deo [Swiss-Prot]
  • 2-keto-3-deoxygluconate 6-phosphate aldolase and 2-keto-4-hydroxyglutarate aldolase; multifunctional: 2-keto-3-deoxygluconate 6-phosphate aldolase; 2-keto-4-hydroxyglutarate aldolase; oxaloacetate decarboxylase [Escherichia coli K12]gi|15831814|ref|NP_31 [nrdb_11152004_Chlamydomonas]
  • KHG/KDPG aldolase [Includes: 4-hydroxy-2-oxoglutarate aldolase (2-keto-4-hydroxyglutarate aldolase) (KHG-aldolase); 2-dehydro-3-deoxy-phosphogluconate aldolase (Phospho-2-dehydro-3-deoxygluconate aldolase) (Phospho-2-keto-3-deoxygluconate aldolase) (2-ket [NCBI-RefSeq_human_na_08-09-2006_reversed.fasta]
  • Chain B, Kdpg Aldolase From Escherichia Coli [nr-271106-contam.fasta]
  • Chain B, Schiff Base Intermediate In Kdpg Aldolase From Escherichia Coli [nr-271106-contam.fasta]
  • phospho-2-dehydro-3-deoxygluconate aldolase [Escherichia coli] [nr-271106-contam.fasta]
  • 2-keto-3-deoxy-6-phosphogluconate aldolase [nr-271106-contam.fasta]
  • Chain C, Kdpg Aldolase From Escherichia Coli [nr-271106-contam.fasta]
  • Chain A, Structure Of 2-Keto-3-Deoxy-6-Phosphogluconate Aldolase From Escherichia Coli [nr-271106-contam.fasta]
  • Chain C, Structure Of 2-Keto-3-Deoxy-6-Phosphogluconate Aldolase From Escherichia Coli [nr-271106-contam.fasta]
  • Chain A, Kdpg Aldolase From Escherichia Coli [nr-271106-contam.fasta]
  • Chain C, Schiff Base Intermediate In Kdpg Aldolase From Escherichia Coli [nr-271106-contam.fasta]
  • Chain B, Structure Of 2-Keto-3-Deoxy-6-Phosphogluconate Aldolase From Escherichia Coli [nr-271106-contam.fasta]
  • Chain A, Schiff Base Intermediate In Kdpg Aldolase From Escherichia Coli [nr-271106-contam.fasta]
  • 4-hydroxy-2-oxoglutarate aldolase [Escherichia coli] [nr-271106-contam.fasta]
  • KHG/KDPG aldolase OS=Escherichia coli (strain K12) GN=eda PE=1 SV=1 [uniprot-Ecoli-reviewed-110511.fasta]
    • Organism: Escherichia coli
    Length: 213 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKNWKTSAES ILTTGPVVPV IVVKKLEHAV PMAKALVAGG VRVLEVTLRT ECAVDAIRAI  60
   61 AKEVPEAIVG AGTVLNPQQL AEVTEAGAQF AISPGLTEPL LKAATEGTIP LIPGISTVSE 120
  121 LMLGMDYGLK EFKFFPAEAN GGVKALQAIA GPFSQVRFCP TGGISPANYR DYLALKSVLC 180
  181 IGGSWLVPAD ALEAGDYDRI TKLAREAVEG AKL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..213] PSI-BLAST 43.0 KDPG aldolase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • 2-dehydro-3-deoxy-phosphogluconate aldolase activity
    		•  3.5031381823147 bayes_pls_golite062009
  • catalytic activity
    		•  2.67031204377352 bayes_pls_golite062009
  • fructose-bisphosphate aldolase activity
    		•  0.840107349031025 bayes_pls_golite062009
  • lyase activity
    		•  0.740424046054758 bayes_pls_golite062009
  • transferase activity, transferring aldehyde or ketonic groups
    		•  0.643395146148785 bayes_pls_golite062009
  • transferase activity
    		•  0.464721888799972 bayes_pls_golite062009
  • aldehyde-lyase activity
    		•  0.351872954170322 bayes_pls_golite062009
  • transaldolase activity
    		•  0.337067552042715 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.94

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle