YRC Public Data Repository - Protein Structure Prediction

Protein:	ALKH_ECOLI
Organism:	Escherichia coli
Length:	213 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ALKH_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|109714266, gi... - gi\|109947045\|ref\|YP_664273.1\| 2-dehydro-3-deoxyphosphogluconate aldolase / 4-hydroxy-2-oxoglutarate ...	188.0	[0..1]	[212..1]
gi\|71278295, gi\|... - gi\|71278295\|ref\|YP_269004.1\| keto-hydroxyglutarate-aldolase/keto-deoxy-phosphogluconate aldolase [Co...	187.0	[0..2]	[212..5]
gi\|108563462, gi... - gi\|108563462\|ref\|YP_627778.1\| 2-keto-3-deoxy-6-phosphogluconate aldolase [Helicobacter pylori HPAG1]...	186.0	[0..5]	[210..2]
gi\|113461739, gi... - gi\|23467619\|ref\|ZP_00123199.1\| COG0800: 2-keto-3-deoxy-6-phosphogluconate aldolase [Haemophilus somn...	186.0	[0..1]	[212..1]
gi\|83631294, gi\|... - gi\|83643251\|ref\|YP_431686.1\| 2-keto-3-deoxy-6-phosphogluconate aldolase [Hahella chejuensis KCTC 239...	186.0	[0..2]	[211..8]
gi\|7436631 - pir\|\|C64657 2-dehydro-3-deoxy-phosphogluconate aldolase (EC 4.1.2.14) - Helicobacter pylori (strain ... gi\|2314248, gi\|1... - gi\|2314248\|gb\|AAD08142.1\| 2-keto-3-deoxy-6-phosphogluconate aldolase (eda) [Helicobacter pylori 2669...	186.0	[0..5]	[210..2]
gi\|170718550, gi... - gi\|53728725\|ref\|ZP_00131830.2\| COG0800: 2-keto-3-deoxy-6-phosphogluconate aldolase [Haemophilus somn...	185.0	[0..1]	[212..1]
gi\|92114857, gi\|... - gi\|92114857\|ref\|YP_574785.1\| 2-keto-3-deoxy-phosphogluconate aldolase [Chromohalobacter salexigens D...	183.0	[0..3]	[211..10]
gi\|127512973, gi... - gi\|78366535\|ref\|ZP_00836814.1\| KDPG and KHG aldolase [Shewanella sp. PV-4], gi\|78361325\|gb\|EAP03150....	182.0	[0..3]	[211..5]
gi\|49611929, gi\|... - gi\|50121403\|ref\|YP_050570.1\| keto-hydroxyglutarate-aldolase/keto-deoxy-phosphogluconate aldolase [Pe...	182.0	[0..1]	[212..1]

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Predicted Domain #1

Region A:
Residues: [1-213]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKNWKTSAES ILTTGPVVPV IVVKKLEHAV PMAKALVAGG VRVLEVTLRT ECAVDAIRAI  60
   61 AKEVPEAIVG AGTVLNPQQL AEVTEAGAQF AISPGLTEPL LKAATEGTIP LIPGISTVSE 120
  121 LMLGMDYGLK EFKFFPAEAN GGVKALQAIA GPFSQVRFCP TGGISPANYR DYLALKSVLC 180
  181 IGGSWLVPAD ALEAGDYDRI TKLAREAVEG AKL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	43.0
Match:	1euaA
Description:	KDPG aldolase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
2-dehydro-3-deoxy-phosphogluconate aldolase activity	3.5031381823147	bayes_pls_golite062009
catalytic activity	2.67031204377352	bayes_pls_golite062009
fructose-bisphosphate aldolase activity	0.840107349031025	bayes_pls_golite062009
lyase activity	0.740424046054758	bayes_pls_golite062009
transferase activity, transferring aldehyde or ketonic groups	0.643395146148785	bayes_pls_golite062009
transferase activity	0.464721888799972	bayes_pls_golite062009
aldehyde-lyase activity	0.351872954170322	bayes_pls_golite062009
transaldolase activity	0.337067552042715	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: