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Protein Overview: hoe-1

General Information:
Name(s) found: hoe-1 / CE36588 [WormBase]
Description(s) found:
Found 16 descriptions.
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  • WBGene00001983 locus:hoe-1 Ribonuclease Z status:Partially_confirmed UniProt:O44476 protein_id:CCD68706.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 760 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: tRNA 3'-trailer cleavage [IEALink to PubMed article]
    negative regulation of multicellular organism growth [IMPLink to PubMed article]
    positive regulation of growth rate [IMPLink to PubMed articleLink to PubMed articleLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed article]
    Molecular Function: endoribonuclease activity, producing 5'-phosphomonoesters [IEALink to PubMed article]
    hydrolase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAVQKKQKA AHEPPANSIV NIPSQVSIEV LGNGTGLLRA CFILRTPLKT YMFNCPENAC  60
   61 RFLWQLRIRS SSVVDLFITS ANWDNIAGIS SILLSKESNA LSTRLHGAMN IKHFLECIRP 120
  121 FQDSDYGSCK YPSQVEERPY TMENYEDAGL KVTYIPLSPP LNIGSNNEKS KNVKVNNVDI 180
  181 AFLIEMKEAA RRIDTMKLME LKVPKGPLIG KLKSGEAVTL PDGRTIQPDQ VFSSDKVEGD 240
  241 KPLLLVTECT TEDHVKALID SSSLQPFLNG EKQLDYMVHI SDDAVINTPT YRHLMEKLNN 300
  301 PSITHLLING GNPVIPAVES VYKHTRLLRS IAPSLFPALH PIDWSGIITQ NEELSQRQDQ 360
  361 FIRVAPMQRY WMRRGASFNE EPIVNNLLAA EPELSDKAKE LIKEYQKLEK ENKMDCEFPK 420
  421 LTFFGTSSAV PSKYRNVTGY LVEASENSAI LIDVGEGTYG QMRAVFGEDG CKQLLVNLNC 480
  481 VLITHAHQDH MNGLYTIIAR RKEAFESLGA PYRPLVLVCN RNVLKPMKTY SICFENIEHL 540
  541 LEIVDISRYP LTPPGSPGGP PGKRPRLPSP HLPPSRDVLQ DMSSSFDKKA WKLDELKAVQ 600
  601 VHHTRMANGF VMRVAGKRIV FSGDTKPCDL LVEEGKDADV LVHESTFEDG HEADAMRKRH 660
  661 STMGQAVDVG KRMNAKHIIL THFSARYPKV PVLPEYLDKE NIGVAMDMLR VRFDHLPLVS 720
  721 KLLPIFREVF VAELFELTIK KEQRVLKDKE LSEKRGQLKA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..412] PSI-BLAST 51.522879 Crystal structure of ZipD from E. coli
    2 View Details [413..760] PSI-BLAST 56.30103 Crystal structure of RNase Z

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ribonuclease activity
    		•  1.86896377880841 bayes_pls_golite062009
  • binding
    		•  1.25638799652541 bayes_pls_golite062009
  • 3'-tRNA processing endoribonuclease activity
    		•  0.998280249151351 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.980281910076056 bayes_pls_golite062009
  • catalytic activity
    		•  0.941400907161877 bayes_pls_golite062009
  • hydrolase activity
    		•  0.915337370449941 bayes_pls_golite062009
  • RNA binding
    		•  0.794779546418275 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  0.763057588327235 bayes_pls_golite062009
  • endoribonuclease activity
    		•  0.364180397113473 bayes_pls_golite062009
  • endonuclease activity
    		•  0.236604397004899 bayes_pls_golite062009
  • protein binding
    		•  0.0732519352239051 bayes_pls_golite062009
    2
    Term Confidence Notes
  • ribonuclease activity
    		•  1.86896377880841 bayes_pls_golite062009
  • binding
    		•  1.25638799652541 bayes_pls_golite062009
  • 3'-tRNA processing endoribonuclease activity
    		•  0.998280249151351 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.980281910076056 bayes_pls_golite062009
  • catalytic activity
    		•  0.941400907161877 bayes_pls_golite062009
  • hydrolase activity
    		•  0.915337370449941 bayes_pls_golite062009
  • RNA binding
    		•  0.794779546418275 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  0.763057588327235 bayes_pls_golite062009
  • endoribonuclease activity
    		•  0.364180397113473 bayes_pls_golite062009
  • endonuclease activity
    		•  0.236604397004899 bayes_pls_golite062009
  • protein binding
    		•  0.0732519352239051 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.94

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle