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Protein Overview: RHM2_ARATH

General Information:
Name(s) found: RHM2_ARATH [Swiss-Prot]
Description(s) found:
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  • gi|8671876|gb|AAF78439.1|AC018748_18 Contains similarity to dTPD-D-glucose-4,6-dehydratase from Sphingomonas sp.S88 gb|U51197 and contains a NAD dependent epimerase/dehydratase PF|01370 domain. [Arabidopsis thaliana] [NCBI NR]
  • gi|62901054|sp|Q9LPG6.1|RHM2_ARATH RecName: Full=Probable rhamnose biosynthetic enzyme 2; AltName: Full=Protein RHAMNOSE BIOSYNTHESIS 2; AltName: Full=NDP-rhamnose synthase; AltName: Full=Protein MUCILAGE-MODIFIED 4; AltName: Full=UDP-L-rhamnose synthase [NCBI NR]
  • gi|42562732|ref|NP_564633.2| MUM4 (MUCILAGE-MODIFIED 4); UDP-4-keto-6-deoxy-glucose-3,5-epimerase/ UDP-4-keto-rhamnose-4-keto-reductase/ UDP-L-rhamnose synthase/ UDP-glucose 4,6-dehydratase/ catalytic [Arabidopsis thaliana] [NCBI NR]
  • gi|33090264|gb|AAP93963.1| putative UDP-L-rhamnose synthase MUM4 [Arabidopsis thaliana] [NCBI NR]
  • gi|31559259|emb|CAD92667.1| putative NDP-rhamnose synthase [Arabidopsis thaliana] [NCBI NR]
  • pir||B96575 hypothetical protein F22G10.13 [imported] - Arabidopsis thaliana [NCBI NR]
  • gi|12324032|gb|AAG51981.1|AC024260_19 dTDP-D-glucose 4,6-dehydratase, putative; 102946-105028 [Arabidopsis thaliana] [NCBI NR]
  • Trifunctional UDP-glucose 4,6-dehydratase/UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase/UDP-4-keto-L-rhamnose-reductase RHM2 OS=Arabidopsis thaliana GN=RHM2 PE=1 SV=1 [Swiss-Prot]
  • (Q9LPG6) T3F20.18 protein (DTDP-D-glucose 4,6-dehydratase, putative, 102946-105028) (Putative UDP-L-rhamnose synthase MUM4) (Putative NDP-rhamnose synthase) [athaliana3702.FASTAC.txt]
  • putative UDP-L-rhamnose synthase MUM4 [Arabidopsis thaliana]gi|31559259|emb|CAD92667.1| putative NDP-rhamnose synthase [Arabidopsis thaliana]gi|8671876|gb|AAF78439.1| Contains similarity to dTPD-D-glucose-4,6-dehydratase from Sphingomonas sp.S88 gb|U511 [nrdb_11152004_Chlamydomonas]
  • Tax_Id=3702 Probable rhamnose biosynthetic enzyme 2 [EBI-IPI_Arabidopsis_3.11_12-06-2005_reversed.fasta]
  • | Symbols: RHM2, MUM4 | MUM4 (MUCILAGE-MODIFIED 4); catalytic | chr1:19970825-19972907 REVERSE [TAIR_Arabidopsis_na_04-12-2008_con_reversed.fasta]
  • dTDP-D-glucose 4,6-dehydratase, putative; 102946-105028 [Arabidopsis thaliana] [NCBI-RefSeq_human_na_10-15-2008_con_reversed.fasta]
  • putative UDP-L-rhamnose synthase MUM4 [Arabidopsis thaliana] [nr-271106-contam.fasta]
  • Probable rhamnose biosynthetic enzyme 2 (RHAMNOSE BIOSYNTHESIS 2 protein) (NDP-rhamnose synthase) (MUCILAGE-MODIFIED4 protein) (UDP-L-rhamnose synthase MUM4) [nr-271106-contam.fasta]
  • MUM4 (MUCILAGE-MODIFIED 4); catalytic [Arabidopsis thaliana] [nr-271106-contam.fasta]
  • Contains similarity to dTPD-D-glucose-4,6-dehydratase from Sphingomonas sp.S88 gb|U51197 and contains a NAD dependent epimerase/dehydratase PF|01370 domain. [Arabidopsis thaliana] [nr-271106-contam.fasta]
  • putative NDP-rhamnose synthase [Arabidopsis thaliana] [nr-271106-contam.fasta]
  • | Symbols: MUM4, RHM2, ATRHM2, ATMUM4 | NAD-dependent epimerase/dehydratase family protein | chr1:19967157-19969239 REVERSE LENGTH=667 [TAIR_A_Thaliana_10_12-14-2010_reversed.fasta]
  • Probable rhamnose biosynthetic enzyme 2 OS=Arabidopsis thaliana GN=RHM2 PE=1 SV=1 [ARATH-contam.fasta]
    • Organism: Arabidopsis thaliana
    Length: 667 amino acids

    Gene Ontology:
    Cellular Component: soluble fraction [IDA]
    Biological Process: UDP-rhamnose biosynthetic process [IDA]
    mucilage biosynthetic process [IMP]
    metabolic process [ISS]
    seed coat development [IMP]
    Molecular Function: UDP-glucose 4,6-dehydratase activity [IDA]
    UDP-L-rhamnose synthase activity [IDA][ISS]
    catalytic activity [ISS]
    UDP-4-keto-rhamnose-4-keto-reductase activity [TAS]
    UDP-4-keto-6-deoxy-glucose-3,5-epimerase activity [TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDDTTYKPKN ILITGAAGFI ASHVANRLIR NYPDYKIVVL DKLDYCSDLK NLDPSFSSPN  60
   61 FKFVKGDIAS DDLVNYLLIT ENIDTIMHFA AQTHVDNSFG NSFEFTKNNI YGTHVLLEAC 120
  121 KVTGQIRRFI HVSTDEVYGE TDEDAAVGNH EASQLLPTNP YSATKAGAEM LVMAYGRSYG 180
  181 LPVITTRGNN VYGPNQFPEK MIPKFILLAM SGKPLPIHGD GSNVRSYLYC EDVAEAFEVV 240
  241 LHKGEIGHVY NVGTKRERRV IDVARDICKL FGKDPESSIQ FVENRPFNDQ RYFLDDQKLK 300
  301 KLGWQERTNW EDGLKKTMDW YTQNPEWWGD VSGALLPHPR MLMMPGGRLS DGSSEKKDVS 360
  361 SNTVQTFTVV TPKNGDSGDK ASLKFLIYGK TGWLGGLLGK LCEKQGITYE YGKGRLEDRA 420
  421 SLVADIRSIK PTHVFNAAGL TGRPNVDWCE SHKPETIRVN VAGTLTLADV CRENDLLMMN 480
  481 FATGCIFEYD ATHPEGSGIG FKEEDKPNFF GSFYSKTKAM VEELLREFDN VCTLRVRMPI 540
  541 SSDLNNPRNF ITKISRYNKV VDIPNSMTVL DELLPISIEM AKRNLRGIWN FTNPGVVSHN 600
  601 EILEMYKNYI EPGFKWSNFT VEEQAKVIVA ARSNNEMDGS KLSKEFPEML SIKESLLKYV 660
  661 FEPNKRT

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..371] PSI-BLAST 98.522879 dTDP-glucose 4,6-dehydratase (RmlB)
    2 View Details [372..667] PSI-BLAST 45.39794 gdp-mannose-3', 5' -epimerase (arabidopsis thaliana), with gdp-alpha-d-mannose and gdp-beta-l-galactose bound in the active site.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • UDP-glucose 4-epimerase activity
    		•  2.13934644118967 bayes_pls_golite062009
  • catalytic activity
    		•  1.79741889688267 bayes_pls_golite062009
  • steroid dehydrogenase activity
    		•  1.75109362865449 bayes_pls_golite062009
  • steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  1.55012034958204 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH-OH group of donors
    		•  1.03956654822048 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.868888700854563 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  0.82673050487418 bayes_pls_golite062009
  • DNA binding
    		•  0.790382977752475 bayes_pls_golite062009
  • binding
    		•  0.784517759335365 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.613310508772122 bayes_pls_golite062009
  • transcription factor activity
    		•  0.11102650759187 bayes_pls_golite062009
    2
    Term Confidence Notes
  • UDP-glucose 4-epimerase activity
    		•  2.13934644118967 bayes_pls_golite062009
  • catalytic activity
    		•  1.79741889688267 bayes_pls_golite062009
  • steroid dehydrogenase activity
    		•  1.75109362865449 bayes_pls_golite062009
  • steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  1.55012034958204 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH-OH group of donors
    		•  1.03956654822048 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.868888700854563 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  0.82673050487418 bayes_pls_golite062009
  • DNA binding
    		•  0.790382977752475 bayes_pls_golite062009
  • binding
    		•  0.784517759335365 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.613310508772122 bayes_pls_golite062009
  • transcription factor activity
    		•  0.11102650759187 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.92

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle