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Protein Overview: gi|7594553, gi|1...

General Information:
Name(s) found: gi|94450858 [NCBI NR]
gi|7594553 [NCBI NR]
gi|15229816 [NCBI NR]
gi|11358029 [NCBI NR]
Description(s) found:
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  • gi|94450858|gb|ABF19799.1| dicer-like 3 [Arabidopsis thaliana] [NCBI NR]
  • gi|7594553|emb|CAB88120.1| putative protein [Arabidopsis thaliana] [NCBI NR]
  • gi|15229816|ref|NP_189978.1| ribonuclease III family protein [Arabidopsis thaliana] [NCBI NR]
  • pir||T48946 hypothetical protein T15B3.60 - Arabidopsis thaliana [NCBI NR]
  • (Q9LXW7) Hypothetical protein [athaliana3702.FASTAC.txt]
  • putative protein [Arabidopsis thaliana]gi|11358029|pir||T48946 hypothetical protein T15B3.60 - Arabidopsis thalianagi|15229816|ref|NP_189978.1| ribonuclease III family protein [Arabidopsis thaliana] [nrdb_11152004_Chlamydomonas]
  • Tax_Id=3702 Ribonuclease III family protein [EBI-IPI_Arabidopsis_3.11_12-06-2005_reversed.fasta]
  • | Symbols: DCL3 | DCL3 (DICER-LIKE 3); RNA binding / ribonuclease III | chr3:15764535-15771817 FORWARD [TAIR_Arabidopsis_na_04-12-2008_con_reversed.fasta]
  • putative protein [Arabidopsis thaliana] [nr-271106-contam.fasta]
  • dicer-like 3 [Arabidopsis thaliana] [nr-271106-contam.fasta]
  • DCL3 (DICER-LIKE 3); ATP binding / ATP-dependent helicase/ RNA binding / ribonuclease III [Arabidopsis thaliana] [nr-271106-contam.fasta]
  • | Symbols: DCL3, ATDCL3 | dicer-like 3 | chr3:15753548-15760830 FORWARD LENGTH=1531 [TAIR_A_Thaliana_10_12-14-2010_reversed.fasta]
  • Isoform 2 of Endoribonuclease Dicer homolog 3 OS=Arabidopsis thaliana GN=DCL3 [ARATH-contam.fasta]
  • Isoform of Q9LXW7, Isoform 2 of Endoribonuclease Dicer homolog 3 OS=Arabidopsis thaliana GN=DCL3 [ARATH.fasta.20160308]
    • Organism: Arabidopsis thaliana
    Length: 1531 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA]
    nucleolus [IDA]
    Biological Process: [NOT]production of miRNAs involved in gene silencing by miRNA [IGI]
    RNA processing [ISS]
    maintenance of DNA methylation [IMP]
    production of siRNA involved in RNA interference [IMP]
    production of ta-siRNAs involved in RNA interference [IMP]
    Molecular Function: RNA binding [ISS]
    ribonuclease III activity [ISS]
    double-stranded RNA binding [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHSSLEPEKM EEGGGSNSLK RKFSEIDGDQ NLDSVSSPMM TDSNGSYELK VYEVAKNRNI  60
   61 IAVLGTGIDK SEITKRLIKA MGSSDTDKRL IIFLAPTVNL QCCEIRALVN LKVEEYFGAK 120
  121 GVDKWTSQRW DEEFSKHDVL VMTPQILLDV LRSAFLKLEM VCLLIIDECH HTTGNHPYAK 180
  181 LMKIFNPEER EGVEKFATTV KEGPILYNPS PSCSLELKEK LETSHLKFDA SLRRLQELGK 240
  241 DSFLNMDNKF ETYQKRLSID YREILHCLDN LGLICAHLAA EVCLEKISDT KEESETYKEC 300
  301 SMVCKEFLED ILSTIGVYLP QDDKSLVDLQ QNHLSAVISG HVSPKLKELF HLLDSFRGDK 360
  361 QKQCLILVER IITAKVIERF VKKEASLAYL NVLYLTENNP STNVSAQKMQ IEIPDLFQHG 420
  421 KVNLLFITDV VEEGFQVPDC SCMVCFDLPK TMCSYSQSQK HAKQSNSKSI MFLERGNPKQ 480
  481 RDHLHDLMRR EVLIQDPEAP NLKSCPPPVK NGHGVKEIGS MVIPDSNITV SEEAASTQTM 540
  541 SDPPSRNEQL PPCKKLRLDN NLLQSNGKEK VASSKSKSSS SAAGSKKRKE LHGTTCANAL 600
  601 SGTWGENIDG ATFQAYKFDF CCNISGEVYS SFSLLLESTL AEDVGKVEMD LYLVRKLVKA 660
  661 SVSPCGQIRL SQEELVKAKY FQQFFFNGMF GKLFVGSKSQ GTKREFLLQT DTSSLWHPAF 720
  721 MFLLLPVETN DLASSATIDW SAINSCASIV EFLKKNSLLD LRDSDGNQCN TSSGQEVLLD 780
  781 DKMEETNLIH FANASSDKNS LEELVVIAIH TGRIYSIVEA VSDSSAMSPF EVDASSGYAT 840
  841 YAEYFNKKYG IVLAHPNQPL MKLKQSHHAH NLLVDFNEEM VVKTEPKAGN VRKRKPNIHA 900
  901 HLPPELLARI DVPRAVLKSI YLLPSVMHRL ESLMLASQLR EEIDCSIDNF SISSTSILEA 960
  961 VTTLTCPESF SMERLELLGD SVLKYVASCH LFLKYPDKDE GQLSRQRQSI ISNSNLHRLT1020
 1021 TSRKLQGYIR NGAFEPRRWT APGQFSLFPV PCKCGIDTRE VPLDPKFFTE NMTIKIGKSC1080
 1081 DMGHRWVVSK SVSDCAEALI GAYYVSGGLS ASLHMMKWLG IDVDFDPNLV VEAINRVSLR1140
 1141 CYIPKEDELI ELERKIQHEF SAKFLLKEAI THSSLRESYS YERLEFLGDS VLDFLITRHL1200
 1201 FNTYEQTGPG EMTDLRSACV NNENFAQVAV KNNLHTHLQR CATVLETQIN DYLMSFQKPD1260
 1261 ETGRSIPSIQ GPKALGDVVE SIAGALLIDT RLDLDQVWRV FEPLLSPLVT PDKLQLPPYR1320
 1321 ELNELCDSLG YFFRVKCSND GVKAQATIQL QLDDVLLTGD GSEQTNKLAL GKAASHLLTQ1380
 1381 LEKRNISRKT SLGDNQSSMD VNLACNHSDR ETLTSETTEI QSIVIPFIGP INMKKGGPRG1440
 1441 TLHEFCKKHL WPMPTFDTSE EKSRTPFEFI DGGEKRTSFS SFTSTITLRI PNREAVMYAG1500
 1501 EARPDKKSSF DSAVVELLYE LERRKIVIIQ K

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..562] PSI-BLAST 33.154902 Structure of the SWI2/SNF2 chromatin remodeling domain of eukaryotic Rad54
    2 View Details [563..608] PSI-BLAST 35.522879 Structure of the RecQ Catalytic Core
    3 View Details [609..733] deduced N/A No confident structure predictions are available.
    4 View Details [734..1056] PSI-BLAST 45.39794 Crystal Structure of Dicer from Giardia intestinalis
    5 View Details [1057..1143] deduced N/A No confident structure predictions are available.
    6 View Details [1144..1383] PSI-BLAST 51.0 RNase III endonuclease catalytic domain; RNase III, C-terminal domain
    7 View Details [1384..1531] PSI-BLAST 13.045757 dsRNA-dependent protein kinase pkr

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • catalytic activity
    		•  1.37148167194523 bayes_pls_golite062009
  • binding
    		•  0.712909626033412 bayes_pls_golite062009
  • hydrolase activity
    		•  0.42374852534029 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6
    Term Confidence Notes
  • RNA binding
    		•  2.103878681691 bayes_pls_golite062009
  • endoribonuclease activity
    		•  2.02847548000256 bayes_pls_golite062009
  • endonuclease activity
    		•  1.52328576888271 bayes_pls_golite062009
  • binding
    		•  1.36306903445995 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.33734225890407 bayes_pls_golite062009
  • double-stranded RNA binding
    		•  0.80785216315429 bayes_pls_golite062009
  • catalytic activity
    		•  0.328884095744829 bayes_pls_golite062009
  • protein binding
    		•  0.018276859224266 bayes_pls_golite062009
    7
    Term Confidence Notes
  • RNA binding
    		•  2.103878681691 bayes_pls_golite062009
  • binding
    		•  1.36306903445995 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.33734225890407 bayes_pls_golite062009
  • double-stranded RNA binding
    		•  0.80785216315429 bayes_pls_golite062009
  • catalytic activity
    		•  0.328884095744829 bayes_pls_golite062009
  • protein binding
    		•  0.018276859224266 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle