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Protein Overview: LEU12_ARATH

General Information:
Name(s) found: LEU12_ARATH [Swiss-Prot]
Description(s) found:
Found 17 descriptions.
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  • 2-isopropylmalate synthase 2, chloroplastic OS=Arabidopsis thaliana GN=IPMS2 PE=1 SV=1 [Swiss-Prot]
    • Organism: Arabidopsis thaliana
    Length: 631 amino acids

    Gene Ontology:
    Cellular Component: chloroplast [IDA]
    chloroplast envelope [IDA]
    Biological Process: leucine biosynthetic process [IDA][IGI]
    Molecular Function: 2-isopropylmalate synthase activity [IDA][IGI][ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MESSILKSPN LSSPSFGVPS IPALSSSSTS PFSSLHLRSQ NHRTISLTTA GKFRVSYSLS  60
   61 ASSPLPPHAP RRRPNYIPNR ISDPNYVRIF DTTLRDGEQS PGATLTSKEK LDIARQLAKL 120
  121 GVDIIEAGFP AASKDDFEAV KTIAETVGNT VDENGYVPVI CGLSRCNKKD IETAWEAVKY 180
  181 AKRPRIHTFI ATSDIHLKYK LKKSKEEVIE IARNMVRFAR SLGCEDVEFS PEDAGRSERE 240
  241 YLYEILGEVI KAGATTLNIP DTVGITLPSE FGQLIADIKA NTPGIQNVII STHCQNDLGL 300
  301 STANTLSGAH SGARQVEVTI NGIGERAGNA SLEEVVMAIK CRGDHVLGGL FTGIDTRHIV 360
  361 MTSKMVEEYT GMQTQPHKAI VGANAFAHES GIHQDGMLKH KGTYEIMSPE EIGLERSNDA 420
  421 GIVLGKLSGR HALKDRLNEL GYVLDDGQLS NLFWRFKAVA EQKKRVTDAD LIALVSDEVF 480
  481 QPEAVWKLLD MQITCGTLGL STSTVKLADS DGKEHVACSV GTGPVDAAYK AVDLIVKEPA 540
  541 TLLEYSMNAV TEGIDAIATT RVLIRGDNNY SSTNAVTGES VERTFSGTGA GMDIVVSSVK 600
  601 AYVGALNKML GFKEHTSTLS KTPLETNEVP A

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..631] PSI-BLAST 124.0 Crystal Structure of LeuA from Mycobacterium tuberculosis

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • 2-isopropylmalate synthase activity
    		•  3.07962096729216 bayes_pls_golite062009
  • transferase activity, transferring aldehyde or ketonic groups
    		•  2.96685031644778 bayes_pls_golite062009
  • catalytic activity
    		•  2.67031204377352 bayes_pls_golite062009
  • porphobilinogen synthase activity
    		•  1.24455949903754 bayes_pls_golite062009
  • binding
    		•  1.1388634428163 bayes_pls_golite062009
  • lyase activity
    		•  0.740424046054758 bayes_pls_golite062009
  • transferase activity
    		•  0.464721888799972 bayes_pls_golite062009
  • carbon-carbon lyase activity
    		•  0.36754360512349 bayes_pls_golite062009
  • transaldolase activity
    		•  0.184100272651834 bayes_pls_golite062009
  • fructose-bisphosphate aldolase activity
    		•  0.0818126250353252 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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