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Protein Overview: gi|4567234, gi|2...

General Information:
Name(s) found: gi|4567234 [NCBI NR]
gi|25286034 [NCBI NR]
gi|15226577 [NCBI NR]
Description(s) found:
Found 11 descriptions.
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  • gi|4567234|gb|AAD23649.1| putative dihydrofolate reductase-thymidylate synthase [Arabidopsis thaliana] [NCBI NR]
  • pir||F84602 hypothetical protein At2g21550 [imported] - Arabidopsis thaliana [NCBI NR]
  • gi|15226577|ref|NP_179750.1| bifunctional dihydrofolate reductase-thymidylate synthase, putative / DHFR-TS, putative [Arabidopsis thaliana] [NCBI NR]
    • Organism: Arabidopsis thaliana
    Length: 492 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: nucleotide biosynthetic process [IEA]
    dTMP biosynthetic process [IEA]
    glycine biosynthetic process [IEA]
    one-carbon metabolic process [IEA]
    Molecular Function: thymidylate synthase activity [IEA]
    dihydrofolate reductase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASTGETICN NGQSAVSVTR RRSYQVVIAA TRDMGLGMDM KLPWDLPSEY QFFQDVTTRT  60
   61 SDPTKRNATI MGRKSWESTP LEIRPLPGRL NIVLTKSSCH NIAIDENVLV SSSMESALEL 120
  121 LATEPYSLSI EKVFVIGGGE LLRNYMNASI CDAIHLTEID ISVPCDAFAP RVDTSLYRPW 180
  181 YSSFPVVENG IRYSFNTYVR RKDAIVGSGE KKSVAESDLK EYSFLPKMVF ERHEEFGYLN 240
  241 LVQNIISSGD MNDNSTLSKF GCQMRFNLRK TFPLLTTKKI FWLGVVEEIL QLISGSNNPK 300
  301 ENGSHIWDTD EAKEYLDSFG VNATEEDGDN PFLHGLHWKH CDARFVIQEF SQLSDVINKI 360
  361 KNNPHDQRIM LAACNPLDFK LSVSPCHTFT QFYVANGEVS CQIYQSSTEA SIGIPFSIAT 420
  421 YSLLTCIIAH VCDLGAGDFI HVIGQAYINK AHVKAIQKQL QISPKPFPIL KINPEKKKMD 480
  481 NFEASDLELM RI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..492] PSI-BLAST 152.0 Crystal structure of DHFR-TS from Cryptosporidium hominis

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • thymidylate synthase activity
    		•  6.6988475347328 bayes_pls_golite062009
  • 5,10-methylenetetrahydrofolate-dependent methyltransferase activity
    		•  6.29181090719132 bayes_pls_golite062009
  • dihydrofolic acid binding
    		•  5.17709559620199 bayes_pls_golite062009
  • dihydrofolate reductase activity
    		•  4.66343252900911 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
    		•  4.14137539326183 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH group of donors
    		•  3.88025481634404 bayes_pls_golite062009
  • binding
    		•  1.89072001556053 bayes_pls_golite062009
  • catalytic activity
    		•  1.73427871128495 bayes_pls_golite062009
  • transferase activity
    		•  1.72626940963556 bayes_pls_golite062009
  • methyltransferase activity
    		•  0.927096828883487 bayes_pls_golite062009
  • transferase activity, transferring one-carbon groups
    		•  0.91282507161672 bayes_pls_golite062009
  • oxidoreductase activity
    		•  0.63757996555211 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.85

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle