Protein Overview: RHM1_ARATH

General Information:
Name(s) found:	RHM1_ARATH [Swiss-Prot]
Description(s) found: Found 17 descriptions. SHOW ALL	Trifunctional UDP-glucose 4,6-dehydratase/UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase/UDP-4-keto-L-rhamnose-reductase RHM1 OS=Arabidopsis thaliana GN=RHM1 PE=1 SV=1 [Swiss-Prot]
Organism:	Arabidopsis thaliana
Length:	669 amino acids
Gene Ontology:
Cellular Component:	soluble fraction [IDA]
Biological Process:	flavonol biosynthetic process [IMP] UDP-rhamnose biosynthetic process [IDA][IMP] nucleotide-sugar metabolic process [ISS] auxin efflux [IMP]
Molecular Function:	UDP-glucose 4,6-dehydratase activity [IDA] UDP-L-rhamnose synthase activity [IDA] catalytic activity [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASYTPKNIL ITGAAGFIAS HVANRLIRSY PDYKIVVLDK LDYCSNLKNL NPSKHSPNFK  60
   61 FVKGDIASAD LVNHLLITEG IDTIMHFAAQ THVDNSFGNS FEFTKNNIYG THVLLEACKV 120
  121 TGQIRRFIHV STDEVYGETD EDALVGNHEA SQLLPTNPYS ATKAGAEMLV MAYGRSYGLP 180
  181 VITTRGNNVY GPNQFPEKLI PKFILLAMRG QVLPIHGDGS NVRSYLYCED VAEAFEVVLH 240
  241 KGEVGHVYNI GTKKERRVND VAKDICKLFN MDPEANIKFV DNRPFNDQRY FLDDQKLKKL 300
  301 GWSERTTWEE GLKKTMDWYT QNPEWWGDVS GALLPHPRML MMPGGRHFDG SEDNSLAATL 360
  361 SEKPSQTHMV VPSQRSNGTP QKPSLKFLIY GKTGWIGGLL GKICDKQGIA YEYGKGRLED 420
  421 RSSLLQDIQS VKPTHVFNSA GVTGRPNVDW CESHKTETIR ANVAGTLTLA DVCREHGLLM 480
  481 MNFATGCIFE YDDKHPEGSG IGFKEEDTPN FTGSFYSKTK AMVEELLKEY DNVCTLRVRM 540
  541 PISSDLNNPR NFITKISRYN KVVNIPNSMT VLDELLPISI EMAKRNLKGI WNFTNPGVVS 600
  601 HNEILEMYRD YINPEFKWAN FTLEEQAKVI VAPRSNNEMD ASKLKKEFPE LLSIKESLIK 660
  661 YAYGPNKKT

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..337]	PSI-BLAST	78.522879	dTDP-glucose 4,6-dehydratase (RmlB)
2	View Details	[338..669]	PSI-BLAST	37.39794	gdp-mannose-3', 5' -epimerase (arabidopsis thaliana), with gdp-alpha-d-mannose and gdp-beta-l-galactose bound in the active site.

Functions predicted (by domain):

#

Gene Ontology predictions

1

Term	Confidence	Notes
UDP-glucose 4-epimerase activity	2.13934644118967	bayes_pls_golite062009
catalytic activity	1.79741889688267	bayes_pls_golite062009
steroid dehydrogenase activity	1.75109362865449	bayes_pls_golite062009
steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1.55012034958204	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	1.03956654822048	bayes_pls_golite062009
nucleic acid binding	0.868888700854563	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	0.82673050487418	bayes_pls_golite062009
DNA binding	0.790382977752475	bayes_pls_golite062009
binding	0.784517759335365	bayes_pls_golite062009
transcription regulator activity	0.613310508772122	bayes_pls_golite062009
transcription factor activity	0.11102650759187	bayes_pls_golite062009

2

Term	Confidence	Notes
UDP-glucose 4-epimerase activity	2.13934644118967	bayes_pls_golite062009
catalytic activity	1.79741889688267	bayes_pls_golite062009
steroid dehydrogenase activity	1.75109362865449	bayes_pls_golite062009
steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1.55012034958204	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	1.03956654822048	bayes_pls_golite062009
nucleic acid binding	0.868888700854563	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	0.82673050487418	bayes_pls_golite062009
DNA binding	0.790382977752475	bayes_pls_golite062009
binding	0.784517759335365	bayes_pls_golite062009
transcription regulator activity	0.613310508772122	bayes_pls_golite062009
transcription factor activity	0.11102650759187	bayes_pls_golite062009

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

Philius confidence legend

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