Protein Overview: RHM3_ARATH

General Information:
Name(s) found:	RHM3_ARATH [Swiss-Prot]
Description(s) found: Found 17 descriptions. SHOW ALL	Trifunctional UDP-glucose 4,6-dehydratase/UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase/UDP-4-keto-L-rhamnose-reductase RHM3 OS=Arabidopsis thaliana GN=RHM3 PE=1 SV=1 [Swiss-Prot]
Organism:	Arabidopsis thaliana
Length:	664 amino acids
Gene Ontology:
Cellular Component:	soluble fraction [IDA]
Biological Process:	UDP-rhamnose biosynthetic process [IDA] nucleotide-sugar metabolic process [ISS]
Molecular Function:	UDP-L-rhamnose synthase activity [IDA][ISS] catalytic activity [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATYKPKNIL ITGAAGFIAS HVANRLVRSY PDYKIVVLDK LDYCSNLKNL NPSKSSPNFK  60
   61 FVKGDIASAD LVNYLLITEE IDTIMHFAAQ THVDNSFGNS FEFTKNNIYG THVLLEACKV 120
  121 TGQIRRFIHV STDEVYGETD EDASVGNHEA SQLLPTNPYS ATKAGAEMLV MAYGRSYGLP 180
  181 VITTRGNNVY GPNQFPEKLI PKFILLAMNG KPLPIHGDGS NVRSYLYCED VAEAFEVVLH 240
  241 KGEVNHVYNI GTTRERRVID VANDISKLFG IDPDSTIQYV ENRPFNDQRY FLDDQKLKKL 300
  301 GWCERTNWEE GLRKTMEWYT ENPEWWGDVS GALLPHPRML MMPGDRHSDG SDEHKNADGN 360
  361 QTFTVVTPTK AGCSGDKRSL KFLIYGKTGW LGGLLGKLCE KQGIPYEYGK GRLEDRASLI 420
  421 ADIRSIKPSH VFNAAGLTGR PNVDWCESHK TETIRVNVAG TLTLADVCRE NDLLMMNFAT 480
  481 GCIFEYDAAH PEGSGIGFKE EDKPNFTGSF YSKTKAMVEE LLREFDNVCT LRVRMPISSD 540
  541 LNNPRNFITK ISRYNKVVNI PNSMTILDEL LPISIEMAKR NLRGIWNFTN PGVVSHNEIL 600
  601 EMYKSYIEPD FKWSNFNLEE QAKVIVAPRS NNEMDGAKLS KEFPEMLSIK DSLIKYVFEP 660
  661 NKRT

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..365]	PSI-BLAST	100.0	dTDP-glucose 4,6-dehydratase (RmlB)
2	View Details	[366..664]	PSI-BLAST	46.522879	gdp-mannose-3', 5' -epimerase (arabidopsis thaliana), with gdp-alpha-d-mannose and gdp-beta-l-galactose bound in the active site.

Functions predicted (by domain):

#

Gene Ontology predictions

1

Term	Confidence	Notes
UDP-glucose 4-epimerase activity	2.13934644118967	bayes_pls_golite062009
catalytic activity	1.79741889688267	bayes_pls_golite062009
steroid dehydrogenase activity	1.75109362865449	bayes_pls_golite062009
steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1.55012034958204	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	1.03956654822048	bayes_pls_golite062009
nucleic acid binding	0.868888700854563	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	0.82673050487418	bayes_pls_golite062009
DNA binding	0.790382977752475	bayes_pls_golite062009
binding	0.784517759335365	bayes_pls_golite062009
transcription regulator activity	0.613310508772122	bayes_pls_golite062009
transcription factor activity	0.11102650759187	bayes_pls_golite062009

2

Term	Confidence	Notes
UDP-glucose 4-epimerase activity	2.13934644118967	bayes_pls_golite062009
catalytic activity	1.79741889688267	bayes_pls_golite062009
steroid dehydrogenase activity	1.75109362865449	bayes_pls_golite062009
steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1.55012034958204	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	1.03956654822048	bayes_pls_golite062009
nucleic acid binding	0.868888700854563	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	0.82673050487418	bayes_pls_golite062009
DNA binding	0.790382977752475	bayes_pls_golite062009
binding	0.784517759335365	bayes_pls_golite062009
transcription regulator activity	0.613310508772122	bayes_pls_golite062009
transcription factor activity	0.11102650759187	bayes_pls_golite062009

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

Philius confidence legend

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