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Protein Overview: TOP1_ARATH

General Information:
Name(s) found: TOP1_ARATH [Swiss-Prot]
Description(s) found:
Found 17 descriptions.
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  • DNA topoisomerase 1 OS=Arabidopsis thaliana GN=TOP1 PE=1 SV=1 [Swiss-Prot]
    • Organism: Arabidopsis thaliana
    Length: 916 amino acids

    Gene Ontology:
    Cellular Component: chromosome [IEA]
    Biological Process: regulation of meristem growth [IMP]
    chromatin remodeling [IGI]
    stem cell maintenance [IGI]
    embryonic development ending in seed dormancy [IMP]
    post-embryonic development [IMP]
    shoot morphogenesis [IMP]
    organ formation [IMP]
    DNA topological change [ISS]
    DNA metabolic process [ISS]
    meristem structural organization [IMP]
    leaf morphogenesis [IMP]
    flower morphogenesis [IMP]
    Molecular Function: protein binding [IPI]
    DNA topoisomerase type I activity [IGI][ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGTETVSKPV MDNGSGDSDD DKPLAFKRNN TVASNSNQSK SNSQRSKAVP TTKVSPMRSP  60
   61 VTSPNGTTPS NKTSIVKSSM PSSSSKASPA KSPLRNDMPS TVKDRSQLQK DQSECKIEHE 120
  121 DSEDDRPLSS ILSGNKGPTS SRQVSSPQPE KKNNGDRPLD RASRIIKDES DDETPISSMF 180
  181 RKKIDSGMSG GNQLSNDEKK PLVQKLHQNG STVKNEVPNG KVLGKRPLEK NSSADQSSLK 240
  241 KAKISASPTS VKMKQDSVKK EIDDKGRVLV SPKMKAKQLS TREDGTDDDD DDDVPISKRF 300
  301 KSDSSNSNTS SAKPKAVKLN STSSAAKPKA RNVVSPRSRA MTKNTKKVTK DSKYSTSSKS 360
  361 SPSSGDGQKK WTTLVHNGVI FPPPYKPHGI KILYKGKPVD LTIEQEEVAT MFAVMRETDY 420
  421 YTKPQFRENF WNDWRRLLGK KHVIQKLDDC DFTPIYEWHL EEKEKKKQMS TEEKKALKEE 480
  481 KMKQEEKYMW AVVDGVKEKI GNFRVEPPGL FRGRGEHPKM GKLKKRIHPC EITLNIGKGA 540
  541 PIPECPIAGE RWKEVKHDNT VTWLAFWADP INPKEFKYVF LGAGSSLKGL SDKEKYEKAR 600
  601 NLTDHIDNIR TTYTKNFTAK DVKMRQIAVA TYLIDKLALR AGNEKDDDEA DTVGCCTLKV 660
  661 GNVECIPPNK IKFDFLGKDS IQYVNTVEVE PLVYKAIGQF QAGKSKTDDL FDELDTSKLN 720
  721 AHLKELVPGL TAKVFRTYNA SITLDEMLSQ ETKDGDVTQK IVVYQKANKE VAIICNHQRT 780
  781 VSKTHGAQIE KLTARIEELK EVLKELKTNL DRAKKGKPPL EGSDGKKIRS LEPNAWEKKI 840
  841 AQQSAKIEKM ERDMHTKEDL KTVALGTSKI NYLDPRITVA WCKRHEVPIE KIFTKSLLEK 900
  901 FAWAMDVEPE YRFSRR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..174] MSA 4.327997 View MSA. No confident structure predictions are available.
    2 View Details [175..334] MSA 3.327996 View MSA. No confident structure predictions are available.
    3 View Details [335..916] PSI-BLAST 1000.0 Eukaryotic DNA topoisomerase I, catalytic core; Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle