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Protein Overview: HIS4_ARATH

General Information:
Name(s) found: HIS4_ARATH [Swiss-Prot]
Description(s) found:
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  • pir||T04813 amidotransferase (EC 2.4.2.-) / cyclase - Arabidopsis thaliana [NCBI NR]
  • gi|7269543|emb|CAB79545.1| glutamine amidotransferase/cyclase [Arabidopsis thaliana] [NCBI NR]
  • gi|4455213|emb|CAB36536.1| glutamine amidotransferase/cyclase [Arabidopsis thaliana] [NCBI NR]
  • gi|15236905|ref|NP_194420.1| AT-HF (HIS HF); imidazoleglycerol-phosphate synthase [Arabidopsis thaliana] [NCBI NR]
  • gi|12643854|sp|Q9SZ30.1|HIS5_ARATH RecName: Full=Imidazole glycerol phosphate synthase hisHF, chloroplastic; Short=ImGP synthase; Short=IGP synthase; Short=IGPS; Includes: RecName: Full=Glutamine amidotransferase; Includes: RecName: Full=Cyclase; Flags: P [NCBI NR]
  • Imidazole glycerol phosphate synthase hisHF, chloroplastic OS=Arabidopsis thaliana GN=At4g26900 PE=1 SV=1 [Swiss-Prot]
  • Imidazole glycerol phosphate synthase hisHF, chloroplastic OS=Arabidopsis thaliana GN=HISN4 PE=2 SV=1 [Swiss-Prot]
  • (Q9SZ30) Imidazole glycerol phosphate synthase hisHF, chloroplast precursor (IGP synthase) (ImGP synthase) (IGPS) [Includes: Glutamine amidotransferase (EC 2.4.2.-); Cyclase (EC 4.1.3.-)] [athaliana3702.FASTAC.txt]
  • glutamine amidotransferase/cyclase [Arabidopsis thaliana]gi|4455213|emb|CAB36536.1| glutamine amidotransferase/cyclase [Arabidopsis thaliana]gi|12643854|sp|Q9SZ30|HIS5_ARATH Imidazole glycerol phosphate synthase hisHF, chloroplast precursor (IGP synthas [nrdb_11152004_Chlamydomonas]
  • Tax_Id=3702 Imidazole glycerol phosphate synthase hisHF, chloroplast precursor [EBI-IPI_Arabidopsis_3.11_12-06-2005_reversed.fasta]
  • | Symbols: HISHF, HISN4, AT-HF | AT-HF (ARABIDOPSIS THALIANA HISF PROTEIN) | chr4:13515520-13519614 FORWARD [TAIR_Arabidopsis_na_04-12-2008_con_reversed.fasta]
  • glutamine amidotransferase/cyclase [Arabidopsis thaliana] [nr-271106-contam.fasta]
  • Imidazole glycerol phosphate synthase hisHF, chloroplast precursor (IGP synthase) (ImGP synthase) (IGPS) [Includes: Glutamine amidotransferase ; Cyclase ] [nr-271106-contam.fasta]
  • AT-HF [Arabidopsis thaliana] [nr-271106-contam.fasta]
  • | Symbols: AT-HF, HISN4 | HIS HF | chr4:13515514-13519608 FORWARD LENGTH=592 [TAIR_A_Thaliana_10_12-14-2010_reversed.fasta]
  • Imidazole glycerol phosphate synthase hisHF, chloroplastic OS=Arabidopsis thaliana GN=At4g26900 PE=2 SV=1 [ARATH-contam.fasta]
    • Organism: Arabidopsis thaliana
    Length: 592 amino acids

    Gene Ontology:
    Cellular Component: chloroplast [IDA][ISS]
    Biological Process: histidine biosynthetic process [IGI][IMP]
    Molecular Function: imidazoleglycerol-phosphate synthase activity [IGI]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEATAAPFSS IVSSRQNFSS SSSIRASSPA SLFLSQKSIG NVNRKFKSPR SLSVRASSTS  60
   61 DSVVTLLDYG AGNVRSIRNA LRHLGFSIKD VQTPGDILNA DRLIFPGVGA FAPAMDVLNR 120
  121 TGMAEALCKY IENDRPFLGI CLGLQLLFDS SEENGPVKGL GVIPGIVGRF DASAGIRVPH 180
  181 IGWNALQVGK DSEILDDVGN RHVYFVHSYR AIPSDENKDW ISSTCNYGES FISSIRRGNV 240
  241 HAVQFHPEKS GEVGLSVLRR FLHPKLPATQ KPMEGKASKL AKRVIACLDV RTNDKGDLVV 300
  301 TKGDQYDVRE QSNENEVRNL GKPVDLAGQY YKDGADEISF LNITGFRDFP LGDLPMIQVL 360
  361 RQTSKNVFVP LTVGGGIRDF TDASGRYYSS LEVAAEYFRS GADKISIGSD AVSAAEEFIK 420
  421 SGVKTGKSSL EQISRVYGNQ AVVVSIDPRR VYVNHPDDVP YKVIRVTNPG PNGEEYAWYQ 480
  481 CTVSGGREGR PIGAFELAKA VEELGAGEIL LNCIDCDGQG KGFDIDLVKL ISDSVGIPVI 540
  541 ASSGAGTPDH FSEVFEKTNA SAALAAGIFH RKEVPIQSVK EHLQEERIEV RI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..61] PSI-BLAST 46.522879 Carbamoyl phosphate synthetase, small subunit N-terminal domain; Carbamoyl phosphate synthetase, small subunit C-terminal domain
    2 View Details [62..592] PSI-BLAST 108.0 Cyclase subunit (or domain) of imidazoleglycerolphosphate synthase HisF; GAT subunit, HisH, (or domain) of imidazoleglycerolphosphate synthase HisF

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • imidazoleglycerol-phosphate synthase activity
    		•  8.34101262147614 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  2.59881271808929 bayes_pls_golite062009
  • carbon-nitrogen ligase activity, with glutamine as amido-N-donor
    		•  2.2869987398931 bayes_pls_golite062009
  • phosphoribosylformylglycinamidine synthase activity
    		•  1.78446504815207 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.7339517212315 bayes_pls_golite062009
  • ligase activity
    		•  1.70348758031146 bayes_pls_golite062009
  • isomerase activity
    		•  1.51213365216354 bayes_pls_golite062009
  • catalytic activity
    		•  1.30391542469987 bayes_pls_golite062009
  • carbamoyl-phosphate synthase activity
    		•  1.28138987648581 bayes_pls_golite062009
  • carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
    		•  1.25854815869201 bayes_pls_golite062009
  • binding
    		•  1.22860407524238 bayes_pls_golite062009
  • ribulose-phosphate 3-epimerase activity
    		•  0.982517927791965 bayes_pls_golite062009
  • orotidine-5'-phosphate decarboxylase activity
    		•  0.758594564254247 bayes_pls_golite062009
  • indole-3-glycerol-phosphate synthase activity
    		•  0.549444136526559 bayes_pls_golite062009
  • transferase activity
    		•  0.540671801549001 bayes_pls_golite062009
  • tryptophan synthase activity
    		•  0.426391242491024 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.0592570704569402 bayes_pls_golite062009
  • kinase activity
    		•  0.0299457182627273 bayes_pls_golite062009
  • protein binding
    		•  0.0152024556625711 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.82

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle