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View Structure Prediction Details

Protein: HIS4_ARATH
Organism: Arabidopsis thaliana
Length: 592 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HIS4_ARATH.

Description E-value Query
Range
Subject
Range
gi|29028958, gi|... - gi|29028958|gb|AAO64858.1| At4g26900 [Arabidopsis thaliana], gi|26452024|dbj|BAC43102.1| putative gl...
430.0 [0..6] [592..6]

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Predicted Domain #1
Region A:
Residues: [1-61]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEATAAPFSS IVSSRQNFSS SSSIRASSPA SLFLSQKSIG NVNRKFKSPR SLSVRASSTS  60
   61 D

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 46.522879
Match: 1bxrB
Description: Carbamoyl phosphate synthetase, small subunit N-terminal domain; Carbamoyl phosphate synthetase, small subunit C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [62-592]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SVVTLLDYGA GNVRSIRNAL RHLGFSIKDV QTPGDILNAD RLIFPGVGAF APAMDVLNRT  60
   61 GMAEALCKYI ENDRPFLGIC LGLQLLFDSS EENGPVKGLG VIPGIVGRFD ASAGIRVPHI 120
  121 GWNALQVGKD SEILDDVGNR HVYFVHSYRA IPSDENKDWI SSTCNYGESF ISSIRRGNVH 180
  181 AVQFHPEKSG EVGLSVLRRF LHPKLPATQK PMEGKASKLA KRVIACLDVR TNDKGDLVVT 240
  241 KGDQYDVREQ SNENEVRNLG KPVDLAGQYY KDGADEISFL NITGFRDFPL GDLPMIQVLR 300
  301 QTSKNVFVPL TVGGGIRDFT DASGRYYSSL EVAAEYFRSG ADKISIGSDA VSAAEEFIKS 360
  361 GVKTGKSSLE QISRVYGNQA VVVSIDPRRV YVNHPDDVPY KVIRVTNPGP NGEEYAWYQC 420
  421 TVSGGREGRP IGAFELAKAV EELGAGEILL NCIDCDGQGK GFDIDLVKLI SDSVGIPVIA 480
  481 SSGAGTPDHF SEVFEKTNAS AALAAGIFHR KEVPIQSVKE HLQEERIEVR I

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 108.0
Match: 1jvnA
Description: Cyclase subunit (or domain) of imidazoleglycerolphosphate synthase HisF; GAT subunit, HisH, (or domain) of imidazoleglycerolphosphate synthase HisF
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
imidazoleglycerol-phosphate synthase activity 8.34101262147614 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 2.59881271808929 bayes_pls_golite062009
carbon-nitrogen ligase activity, with glutamine as amido-N-donor 2.2869987398931 bayes_pls_golite062009
phosphoribosylformylglycinamidine synthase activity 1.78446504815207 bayes_pls_golite062009
nucleic acid binding 1.7339517212315 bayes_pls_golite062009
ligase activity 1.70348758031146 bayes_pls_golite062009
isomerase activity 1.51213365216354 bayes_pls_golite062009
catalytic activity 1.30391542469987 bayes_pls_golite062009
carbamoyl-phosphate synthase activity 1.28138987648581 bayes_pls_golite062009
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity 1.25854815869201 bayes_pls_golite062009
binding 1.22860407524238 bayes_pls_golite062009
ribulose-phosphate 3-epimerase activity 0.982517927791965 bayes_pls_golite062009
orotidine-5'-phosphate decarboxylase activity 0.758594564254247 bayes_pls_golite062009
indole-3-glycerol-phosphate synthase activity 0.549444136526559 bayes_pls_golite062009
transferase activity 0.540671801549001 bayes_pls_golite062009
tryptophan synthase activity 0.426391242491024 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.0592570704569402 bayes_pls_golite062009
kinase activity 0.0299457182627273 bayes_pls_golite062009
protein binding 0.0152024556625711 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle