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Protein Overview: HIS2_ARATH

General Information:
Name(s) found: HIS2_ARATH [Swiss-Prot]
Description(s) found:
Found 22 descriptions.
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  • Histidine biosynthesis bifunctional protein hisIE, chloroplastic OS=Arabidopsis thaliana GN=HISN2 PE=1 SV=1 [Swiss-Prot]
    • Organism: Arabidopsis thaliana
    Length: 281 amino acids

    Gene Ontology:
    Cellular Component: chloroplast [IDA]
    Biological Process: histidine biosynthetic process [TAS]
    Molecular Function: phosphoribosyl-ATP diphosphatase activity [IDA]
    phosphoribosyl-AMP cyclohydrolase activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAVSYNALAQ SLARSSCFIP KPYSFRDTKL RSRSNVVFAC NDNKNIALQA KVDNLLDRIK  60
   61 WDDKGLAVAI AQNVDTGAVL MQGFVNREAL STTISSRKAT FFSRSRSTLW TKGETSNNFI 120
  121 NILDVYVDCD RDSIIYLGTP DGPTCHTGEE TCYYTSVFDQ LNNDEASGNK LALTTLYSLE 180
  181 SIISKRKEES TVPQEGKPSW TRRLLTDDAL LCSKIREEAD ELCRTLEDNE EVSRTPSEMA 240
  241 DVLYHAMVLL SKRGVKMEDV LEVLRKRFSQ SGIEEKQNRT K

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..166] PSI-BLAST 46.221849 Crystal structure of Methanobacterium thermoautotrophicum phosphoribosyl-AMP cyclohydrolase HisI
    2 View Details [167..281] PSI-BLAST 27.69897 Crystal Structure of Phosphoribosyl-ATP Pyrophosphatase from Chromobacterium violaceum (ATCC 12472). NESG TARGET CVR7

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphoribosyl-AMP cyclohydrolase activity
    		•  4.150200144507 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
    		•  2.23740731288751 bayes_pls_golite062009
  • catalytic activity
    		•  1.39985329737364 bayes_pls_golite062009
  • cyclohydrolase activity
    		•  0.79104127517031 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    		•  0.54834173729282 bayes_pls_golite062009
    2
    Term Confidence Notes
  • phosphoribosyl-ATP diphosphatase activity
    		•  3.7001994388833 bayes_pls_golite062009
  • phosphoribosyl-AMP cyclohydrolase activity
    		•  2.61820126109961 bayes_pls_golite062009
  • catalytic activity
    		•  1.00486703080234 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
    		•  0.72725441841528 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle