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View Structure Prediction Details

Protein: HIS2_ARATH
Organism: Arabidopsis thaliana
Length: 281 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HIS2_ARATH.

Description E-value Query
Range
Subject
Range
gi|95134905, gi|... - gi|95929004|ref|ZP_01311749.1| phosphoribosyl-AMP cyclohydrolase [Desulfuromonas acetoxidans DSM 684...
305.0 [0..55] [281..3]

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Predicted Domain #1
Region A:
Residues: [1-166]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAVSYNALAQ SLARSSCFIP KPYSFRDTKL RSRSNVVFAC NDNKNIALQA KVDNLLDRIK  60
   61 WDDKGLAVAI AQNVDTGAVL MQGFVNREAL STTISSRKAT FFSRSRSTLW TKGETSNNFI 120
  121 NILDVYVDCD RDSIIYLGTP DGPTCHTGEE TCYYTSVFDQ LNNDEA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 46.221849
Match: 1zpsA
Description: Crystal structure of Methanobacterium thermoautotrophicum phosphoribosyl-AMP cyclohydrolase HisI
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
phosphoribosyl-AMP cyclohydrolase activity 4.150200144507 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 2.23740731288751 bayes_pls_golite062009
catalytic activity 1.39985329737364 bayes_pls_golite062009
cyclohydrolase activity 0.79104127517031 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.54834173729282 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [167-281]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SGNKLALTTL YSLESIISKR KEESTVPQEG KPSWTRRLLT DDALLCSKIR EEADELCRTL  60
   61 EDNEEVSRTP SEMADVLYHA MVLLSKRGVK MEDVLEVLRK RFSQSGIEEK QNRTK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 27.69897
Match: 2a7wA
Description: Crystal Structure of Phosphoribosyl-ATP Pyrophosphatase from Chromobacterium violaceum (ATCC 12472). NESG TARGET CVR7
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
phosphoribosyl-ATP diphosphatase activity 3.7001994388833 bayes_pls_golite062009
phosphoribosyl-AMP cyclohydrolase activity 2.61820126109961 bayes_pls_golite062009
catalytic activity 1.00486703080234 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 0.72725441841528 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle