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Protein Overview: DRTS1_ARATH

General Information:
Name(s) found: DRTS1_ARATH [Swiss-Prot]
Description(s) found:
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  • gi|4544392|gb|AAD22302.1| dihydrofolate reductase-thymidylate synthase [Arabidopsis thaliana] [NCBI NR]
  • pir||E84539 dihydrofolate reductase-thymidylate synthase [imported] - Arabidopsis thaliana [NCBI NR]
  • gi|21281275|gb|AAM45080.1| putative dihydrofolate reductase-thymidylate synthase [Arabidopsis thaliana] [NCBI NR]
  • gi|21264432|sp|Q05762.2|DRTS1_ARATH RecName: Full=Bifunctional dihydrofolate reductase-thymidylate synthase 1; Short=DHFR-TS 1; Includes: RecName: Full=Dihydrofolate reductase; Includes: RecName: Full=Thymidylate synthase [NCBI NR]
  • gi|17381024|gb|AAL36324.1| putative dihydrofolate reductase-thymidylate synthase [Arabidopsis thaliana] [NCBI NR]
  • gi|15227185|ref|NP_179230.1| THY-1 (THYMIDYLATE SYNTHASE 1); dihydrofolate reductase/ thymidylate synthase [Arabidopsis thaliana] [NCBI NR]
  • Bifunctional dihydrofolate reductase-thymidylate synthase 1 OS=Arabidopsis thaliana GN=THY-1 PE=1 SV=2 [Swiss-Prot]
  • (Q05762) Bifunctional dihydrofolate reductase-thymidylate synthase 1 (DHFR-TS) [Includes: Dihydrofolate reductase (EC 1.5.1.3); Thymidylate synthase (EC 2.1.1.45)] [Swiss-Prot]
  • putative dihydrofolate reductase-thymidylate synthase [Arabidopsis thaliana]gi|17381024|gb|AAL36324.1| putative dihydrofolate reductase-thymidylate synthase [Arabidopsis thaliana]gi|4544392|gb|AAD22302.1| dihydrofolate reductase-thymidylate synthase [Ar [nrdb_11152004_Chlamydomonas]
  • Tax_Id=3702 Bifunctional dihydrofolate reductase-thymidylate synthase 1 [EBI-IPI_Arabidopsis_3.11_12-06-2005_reversed.fasta]
  • | Symbols: THY-1 | THY-1 (THYMIDYLATE SYNTHASE 1) | chr2:7089120-7091415 REVERSE [TAIR_Arabidopsis_na_04-12-2008_con_reversed.fasta]
  • putative dihydrofolate reductase-thymidylate synthase [Arabidopsis thaliana] [nr-271106-contam.fasta]
  • dihydrofolate reductase-thymidylate synthase [Arabidopsis thaliana] [nr-271106-contam.fasta]
  • THY-1 (THYMIDYLATE SYNTHASE 1); dihydrofolate reductase/ thymidylate synthase [Arabidopsis thaliana] [nr-271106-contam.fasta]
  • Bifunctional dihydrofolate reductase-thymidylate synthase 1 (DHFR-TS 1) [Includes: Dihydrofolate reductase ; Thymidylate synthase ] [nr-271106-contam.fasta]
  • | Symbols: THY-1 | thymidylate synthase 1 | chr2:7082038-7084333 REVERSE LENGTH=519 [TAIR_A_Thaliana_10_12-14-2010_reversed.fasta]
  • Bifunctional dihydrofolate reductase-thymidylate synthase 1 OS=Arabidopsis thaliana GN=THY-1 PE=2 SV=2 [ARATH-contam.fasta]
    • Organism: Arabidopsis thaliana
    Length: 519 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: 10-formyltetrahydrofolate biosynthetic process [ISS]
    Molecular Function: thymidylate synthase activity [ISS]
    dihydrofolate reductase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATTTLNDSV TTTLASEPQR TYQVVVAATK EMGIGKDGKL PWNLPTDLKF FKDITLTTSD  60
   61 SSKKNAVVMG RKTWESIPIK YRPLSGRLNV VLTRSGGFDI ANTENVVTCS SVDSALDLLA 120
  121 APPYCLSIER VFVIGGGDIL REALNRPSCD AIHLTEIDTS VDCDTFIPAI DTSVYQPWSS 180
  181 SFPVTENGLR FCFTTFVRVK SSADESSDES NGSQSLQFDG KKFLFLPKMV FDQHEEFLYL 240
  241 NMVEDIISNG NVKNDRTGTG TLSKFGCQMK FNLRRSFPLL TTKRVFWRGV VEELLWFISG 300
  301 STNAKVLQEK GIHIWDGNAS REYLDGIGLT EREEGDLGPV YGFQWRHFGA KYTDMHADYT 360
  361 GQGFDQLVDV IDKIKNNPDD RRIIMSAWNP SDLKLMALPP CHMFAQFYVA EGELSCQMYQ 420
  421 RSADMGLGVP FNIASYSLLT CMLAHVCDLV PGDFIHVLGD AHVYKTHVRP LQEQLLNLPK 480
  481 PFPVMKINPE KKQIDSFVAS DFDLTGYDPH KKIEMKMAV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..519] PSI-BLAST 170.0 Crystal structure of DHFR-TS from Cryptosporidium hominis

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • thymidylate synthase activity
    		•  6.6988475347328 bayes_pls_golite062009
  • 5,10-methylenetetrahydrofolate-dependent methyltransferase activity
    		•  6.29181090719132 bayes_pls_golite062009
  • dihydrofolic acid binding
    		•  5.17709559620199 bayes_pls_golite062009
  • dihydrofolate reductase activity
    		•  4.66343252900911 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
    		•  4.14137539326183 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH group of donors
    		•  3.88025481634404 bayes_pls_golite062009
  • binding
    		•  1.89072001556053 bayes_pls_golite062009
  • catalytic activity
    		•  1.73427871128495 bayes_pls_golite062009
  • transferase activity
    		•  1.72626940963556 bayes_pls_golite062009
  • methyltransferase activity
    		•  0.927096828883487 bayes_pls_golite062009
  • transferase activity, transferring one-carbon groups
    		•  0.91282507161672 bayes_pls_golite062009
  • oxidoreductase activity
    		•  0.63757996555211 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle