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Protein Overview: nhr-25

General Information:
Name(s) found: nhr-25 / CE35856 [WormBase]
Description(s) found:
Found 17 descriptions.
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  • WBGene00003623 locus:nhr-25 Nuclear hormone receptor family member nhr-25 status:Confirmed UniProt:Q19345 protein_id:CAE48496.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 492 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article][IEALink to PubMed article]
    Biological Process: molting cycle, protein-based cuticle [IMPLink to PubMed article]
    positive regulation of vulval development [IMPLink to PubMed article]
    locomotory behavior [IMPLink to PubMed articleLink to PubMed article]
    gonad development [IMPLink to PubMed article]
    nematode larval development [IMPLink to PubMed articleLink to PubMed article]
    positive regulation of growth rate [IMPLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed article]
    post-embryonic body morphogenesis [IMPLink to PubMed article]
    regulation of transcription, DNA-dependent [IEALink to PubMed article]
    oviposition [IMPLink to PubMed articleLink to PubMed article]
    positive regulation of multicellular organism growth [IMPLink to PubMed article]
    reproduction [IMPLink to PubMed article]
    Molecular Function: transcription factor activity [IEALink to PubMed article]
    zinc ion binding [IEALink to PubMed article]
    steroid hormone receptor activity [IEALink to PubMed article]
    sequence-specific DNA binding [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGMKMEAVRA DRMRGGRNKF GSFYKKDRAH RMQRNAMRVS TVQVPAVLGA QSQAQTFYQP  60
   61 PEHQVSSSTT DQNNQINYFD QTKIKTEYIK TEYDAHLQSP TLSSSTNQQL SVSDFIMRPG 120
  121 YLVDPQDSLA VLLGSTIDDP LLRHTFPAAY QLNEVKQEPF DYSEQFIHHS LHDYPTYTSN 180
  181 TTNYATMMPM TTVSSTQSLV TSTSSTTTGR MTEASSTSPI LPLCPAPTEK TVDHFYNSSI 240
  241 AEMCKTLPDD AQIARIFTSV KGTSKPEKHA FSIQVAEENL KDIVIWAKND QLFSKLSLDD 300
  301 QMILLQTSWT TVHIVDITNA MVHGNLLSQY KMSNGDEVPV GLVALLGNQT FVSSWNDVVI 360
  361 RLRNMGFTNF DYCAFRFLAL FDQSMDSFPA VSTARSRVLQ SWREVRCTTA FLEIFEQIRR 420
  421 LAYDSLRYLW NLHSNCPTNW EQFFPEASLV LEMIRTTVNR SASSSVTAIT QVPAIQLPTP 480
  481 QATYTAVPYM AS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..135] MSA 5.436996 View MSA. No confident structure predictions are available.
    2 View Details [136..215] PSI-BLAST 12.69897 Crystal Structure of Vitmain D Receptor and 9-cis Retinoic Acid Receptor DNA-Binding Domains Bound to a DR3 Response Element
    3 View Details [216..492] PSI-BLAST 54.09691 LIGAND-BINDING DOMAIN OF THE HUMAN NUCLEAR RECEPTOR RXR-ALPHA

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • binding
    		•  2.31508164334985 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.02157665604796 bayes_pls_golite062009
  • DNA binding
    		•  1.47175550190876 bayes_pls_golite062009
  • signal transducer activity
    		•  1.430912689846 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.430912689846 bayes_pls_golite062009
  • protein binding
    		•  1.34648900580465 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.29377568150934 bayes_pls_golite062009
  • receptor activity
    		•  1.17902442273252 bayes_pls_golite062009
  • ligand-dependent nuclear receptor activity
    		•  1.16718542519809 bayes_pls_golite062009
  • transcription activator activity
    		•  0.96843436755116 bayes_pls_golite062009
  • transcription factor activity
    		•  0.92060883178562 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.67007540744134 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.89

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle