Protein Overview: ire-1

General Information:
Name(s) found:	ire-1 / CE35836 [WormBase]
Description(s) found: SHOW ONLY BEST	WBGene00002147 locus:ire-1 Serine\/threonine-protein kinase\/endoribonuclease ire-1 status:Confirmed UniProt:Q09499 protein_id:CAA88100.2 [WormBase] gi\|37619792\|emb\|CAA88100.2\| C. elegans protein C41C4.4, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR] gi\|32563857\|ref\|NP_495701.2\| IRE1 kinase related family member (ire-1) [Caenorhabditis elegans] [NCBI NR] gi\|16904242\|gb\|AAL30828.1\|AF435952_1 Ser/Thr protein kinase [Caenorhabditis elegans] [NCBI NR] gi\|115502406\|sp\|Q09499.2\|IRE1_CAEEL RecName: Full=Serine/threonine-protein kinase/endoribonuclease ire-1; AltName: Full=Inositol-requiring protein 2; Includes: RecName: Full=Serine/threonine-protein kinase; Includes: RecName: Full=Endoribonuclease; Flags: [NCBI NR] Serine/threonine-protein kinase/endoribonuclease ire-1 OS=Caenorhabditis elegans GN=ire-1 PE=1 SV=2 [Swiss-Prot] [wormpep115.fasta] CE35836 WBGene00002147 locus:ire-1 serine\/threonine kinase status:Confirmed SW:Q09499 protein_id:CAA88100.2 [wormpep150.fasta] 35836 WBGene00002147 locus:ire-1 serine\/threonine kinase status:Partially_confirmed SW:Q09499 protein_id:CAA88100.2 [wormpep130-phg-ecoli-orf-rand.fasta] IRE1 kinase homolog, Serine Threonine protein kinase receptor precursor, required for survival upon ER stress and unfolded protein response; endoplasmic reticulum to nucleus signalling 2 (human) and Inositol-REquiring 1 (yeast) homologue (109.8 kD) (ire-1 [nrdb_11152004_Chlamydomonas] CE35836 WBGene00002147 locus:ire-1 serine\/threonine kinase status:Partially_confirmed SW:Q09499 protein_id:CAA88100.2 [wormpep132.fasta] 35836 WBGene00002147 locus:ire-1 serine\/threonine kinase status:Confirmed SW:Q09499 protein_id:CAA88100.2 [wormpep150-phg-orf-ecoli-rand.fasta] locus:ire-1 serine\/threonine kinase status:Partially_confirmed TN:CAA88100 protein_id:CAA88100.2 [wormpep115.fasta.reversed] CE35836 WBGene00002147 locus:ire-1 serine\/threonine kinase status:Confirmed UniProt:Q09499 protein_id:CAA88100.2 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta] CE35836 WBGene00002147 locus:ire-1 serine\/threonine kinase status:Confirmed UniProt:Q09499 protein_id:CAA88100.2\| [wormORF-contam.fasta] Hypothetical protein C41C4.4 [Caenorhabditis elegans] [nr-271106-contam.fasta] Serine/threonine-protein kinase/endoribonuclease ire-1 precursor (Inositol-requiring protein 2) [Includes: Serine/threonine-protein kinase ; Endoribonuclease ] [nr-271106-contam.fasta] Ser/Thr protein kinase [Caenorhabditis elegans] [nr-271106-contam.fasta] IRE1 kinase related family member (ire-1) [Caenorhabditis elegans] [nr-271106-contam.fasta] [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr] CE35836 WBGene00002147 locus:ire-1 status:Confirmed UniProt:Q09499 protein_id:CAA88100.2 Serine\/threonine-protein kinase\/endoribonuclease ire-1 [wormpep246-ecoli-contam.fasta] CE35836 WBGene00002147 locus:ire-1 status:Confirmed UniProt:Q09499 protein_id:CAA88100.2 Serine\/threonine-protein kinase [c_elegans-PRJNA13758-WS250-ecoli-contam.fasta]
Organism:	Caenorhabditis elegans
Length:	967 amino acids
Gene Ontology:
Cellular Component:	nucleus [IEA] cytoplasm [IEA]
Biological Process:	electron transport [IEA] signal transduction [IEA] mRNA processing [IEA] protein amino acid phosphorylation [IEA]
Molecular Function:	ATP binding [IEA] DNA binding [IEA] protein tyrosine kinase activity [IEA] zinc ion binding [IEA] non-membrane spanning protein tyrosine kinase activity [IEA] endoribonuclease activity, producing 5'-phosphomonoesters [IEA] protein kinase activity [IEA] protein serine/threonine kinase activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRATFHLFTF IFLLLFSSVI CISTPGFRND HESIGDDEEK TSSTILVSTI DGRLRALDSE  60
   61 TGEIKWTLQE EPVLRSPSAV KQGFTFLPNP LDGSLYVLKN SSLKKLPFNI PQLVHASPCK 120
  121 GNDGILYAGS KKDVWFGIDP KTGLKVETLS SASADRICPA NQKQTIFLGR TEYRVSMFDE 180
  181 KNRGKTWNAT FNDYSAHLLP EVNTWPFKHY ASSSHGYILT FDRETGEMRW EQDLKQPVVA 240
  241 LYLLRDDGLH KLPFEVMGKE TMENVAKNIF TVDQWPTVLG VNAADPQTTS LTNQFFPALF 300
  301 VGESSFGLYA IEALVDHQTI TYSPKLLGPP LLEGPAPIAL TEMEKEEYLP PRRPIIRNIP 360
  361 PSITHKTSDG EYLLLGYHDR PMMTMATIIP TRYPVPGPHK AIGSTIERPP PQLLGPVEPQ 420
  421 KHEDTSFILL LLNNHPIPFY ATLVTMFALL LTVIWQCGRQ WDQQKSTSRM DSFEIVNNPG 480
  481 ESRSAQTSKQ SNRGSFGWAN RKIEIPEGWM AVGSKLMYSP SDILGTGCEG TVVYRGTFDG 540
  541 REVAVKRVVS EFVKFAHREA DLLRESDTHP HVIRYFCMES DSQFRYLALE LCIASLNDYV 600
  601 EQKEVQQNVT IALRDIMKQA TDGLAHLHAS KIVHRDMKPQ NVLITMASQR GEMRAVISDF 660
  661 GLCKRVQPGK NSISRGIASG LAGTDGWIAP EVLISASTSY PVDIFSLGCI FYYVLTSGTH 720
  721 PFGKSLHRQA NIVNGEYTLN KLADLDDWSL ADDLISSMLN VEPLHRLTAD AVLNHPFFWT 780
  781 SEKRLAYFSD VSDRVEKEED NSPVVRRIET DARIVVCGGW REKICDALKE DLRKFRTYKS 840
  841 FSVRDLLRAM RNKKHHYREL PEDVRQSLGD IPDQFLHYFT SRFPRLLLHV YKATEYCSGE 900
  901 AVFKRYYSDD VRARMYPIVE EEERVRKKIK EEMANEVWAR APKPVEQRTP LKLDKRNIKK 960
  961 KSNPNTD

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: ire-1

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: