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Protein Overview: nex-2

General Information:
Name(s) found: nex-2 / CE35364 [WormBase]
Description(s) found:
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  • WBGene00003589 locus:nex-2 Annexin status:Confirmed UniProt:Q7JMT5 protein_id:CAE45742.1 [WormBase]
  • gi|71990594|ref|NP_001022756.1| anNEXin family member (nex-2) [Caenorhabditis elegans] [NCBI NR]
  • gi|34364489|emb|CAE45742.1| C. elegans protein T07C4.9b, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • [wormpep111.fasta]
  • Hypothetical protein T07C4.9b [Caenorhabditis elegans] [nrdb_11152004_Chlamydomonas]
  • CE35364 WBGene00003589 locus:nex-2 status:Confirmed TR:Q7JMT5 protein_id:CAE45742.1 [wormpep150.fasta]
  • 35364 WBGene00003589 locus:nex-2 status:Confirmed TR:Q7JMT5 protein_id:CAE45742.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • locus:nex-2 status:Confirmed TN:CAE45742 protein_id:CAE45742.1 [wormpep115.fasta.reversed]
  • CE35364 WBGene00003589 locus:nex-2 status:Confirmed UniProt:Q7JMT5_CAEEL protein_id:CAE45742.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE35364 WBGene00003589 locus:nex-2 status:Confirmed UniProt:Q7JMT5_CAEEL protein_id:CAE45742.1| [wormORF-contam.fasta]
  • T07C4.9b [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CE35364 WBGene00003589 locus:nex-2 status:Confirmed UniProt:Q7JMT5 protein_id:CAE45742.1 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE35364 WBGene00003589 locus:nex-2 status:Confirmed UniProt:Q7JMT5 protein_id:CAE45742.1 Annexin [wormpep246-ecoli-contam.fasta]
  • Isoform of Q27512, Annexin OS=Caenorhabditis elegans GN=nex-2 PE=1 SV=1 [CAEEL.fasta.20160308]
    • Organism: Caenorhabditis elegans
    Length: 455 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: calcium ion binding [IEALink to PubMed article]
    calcium-dependent phospholipid binding [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNSGGGYPNQ QPSYGGYGQP PQQPGYGNGS YDPYGQPQQQ PYPGGGGQPP YPGSNSNQGG  60
   61 GGYPGQGGAP YPGGSGGYPQ APQYGFSGGQ GSAPQPNQGG YPPQQQQYPP QQGYQQGGQQ 120
  121 QGGGGFFPNQ GYGQPVMIGT PSVFPVQGFN SNADAEVLRK AMKGLGCNNS KVISILCQRT 180
  181 NWQRQEISKA FKVMYGKDLI KELKGELHGD FEDLILALMD APAIYDAKQL HRAMEGLGTK 240
  241 ESVLIEIMTS RTNAQIQQVR DAYKMLFKKD LERDLIGETS GHFKRLLVSL CAGGRDESSQ 300
  301 TDGLRANQDA RRLLQAGEKR LGTDESTFNA ILASQNFSQL RLVFEEYQKA SNHSIEKAIE 360
  361 FEFSGDIRDG LLAVIAVIRN RPAYFAKLLH DSMKGLGTRD NDLIRLCVTR AEYDMGDIRN 420
  421 MFQSLYRTSL ENMIKGDCSG AYKEGLIALV NGNRG

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..151] PSI-BLAST 20.522879 No description for 1y0fB was found.
    2 View Details [152..455] PSI-BLAST 139.0 ANNEXIN IV

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • phospholipase A2 inhibitor activity
    		•  7.29552940171097 bayes_pls_golite062009
  • phospholipid binding
    		•  3.05141207134953 bayes_pls_golite062009
  • binding
    		•  2.96653224858825 bayes_pls_golite062009
  • lipase inhibitor activity
    		•  2.80498669672883 bayes_pls_golite062009
  • phospholipase inhibitor activity
    		•  2.80498669672883 bayes_pls_golite062009
  • actin binding
    		•  2.68781878266644 bayes_pls_golite062009
  • calcium-dependent phospholipid binding
    		•  2.57414697889588 bayes_pls_golite062009
  • protein binding
    		•  2.54206811927155 bayes_pls_golite062009
  • calcium-dependent protein binding
    		•  2.1295362527034 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.89826900114259 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.65977312589087 bayes_pls_golite062009
  • DNA binding
    		•  1.55427160364857 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.49257790869584 bayes_pls_golite062009
  • lipid binding
    		•  1.46457905774769 bayes_pls_golite062009
  • receptor activity
    		•  1.44506842958922 bayes_pls_golite062009
  • phosphatidylserine binding
    		•  1.21299532241397 bayes_pls_golite062009
  • receptor binding
    		•  1.20484213673545 bayes_pls_golite062009
  • signal transducer activity
    		•  1.20428429374783 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.20428429374783 bayes_pls_golite062009
  • acetylcholine receptor activity
    		•  0.948618205286169 bayes_pls_golite062009
  • acetylcholine binding
    		•  0.88218606905406 bayes_pls_golite062009
  • cell surface binding
    		•  0.732574496468741 bayes_pls_golite062009
  • enzyme inhibitor activity
    		•  0.60542945405181 bayes_pls_golite062009
  • actin filament binding
    		•  0.600441079301182 bayes_pls_golite062009
  • structural molecule activity
    		•  0.540239721421754 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle