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Protein Overview: CE34018

General Information:
Name(s) found: CE34018 [WormBase]
Description(s) found:
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  • WBGene00009664 locus:idha-1 Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial status:Confirmed UniProt:Q93714 protein_id:CAB02111.2 [WormBase]
  • gi|71986051|ref|NP_492330.2| hypothetical protein F43G9.1 [Caenorhabditis elegans] [NCBI NR]
  • gi|46397874|sp|Q93714.3|IDH3A_CAEEL RecName: Full=Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial; AltName: Full=Isocitric dehydrogenase; AltName: Full=NAD(+)-specific ICDH; Flags: Precursor [NCBI NR]
  • gi|31043777|emb|CAB02111.2| C. elegans protein F43G9.1, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • (Q93714) Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial precursor (EC 1.1.1.41) (Isocitric dehydrogenase) (NAD+-specific ICDH) [Swiss-Prot]
  • Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial OS=Caenorhabditis elegans GN=idha-1 PE=3 SV=3 [Swiss-Prot]
  • [wormpep104.fasta]
  • Hypothetical protein F43G9.1 [Caenorhabditis elegans]gi|46397874|sp|Q93714|IDHA_CAEEL Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial precursor (Isocitric dehydrogenase) (NAD+-specific ICDH) [nrdb_11152004_Chlamydomonas]
  • CE34018 WBGene00009664 isocitrate dehydrogenase status:Confirmed SW:Q93714 protein_id:CAB02111.2 [wormpep150.fasta]
  • 34018 WBGene00009664 isocitrate dehydrogenase status:Confirmed TR:Q93714 protein_id:CAB02111.2 [wormpep130-phg-ecoli-orf-rand.fasta]
  • CE34018 WBGene00009664 isocitrate dehydrogenase status:Confirmed TR:Q93714 protein_id:CAB02111.2 [wormpep132.fasta]
  • 34018 WBGene00009664 isocitrate dehydrogenase status:Confirmed SW:Q93714 protein_id:CAB02111.2 [wormpep150-phg-orf-ecoli-rand.fasta]
  • isocitrate dehydrogenase status:Confirmed TN:CAB02111 protein_id:CAB02111.2 [wormpep115.fasta.reversed]
  • CE34018 WBGene00009664 isocitrate dehydrogenase status:Confirmed UniProt:Q93714 protein_id:CAB02111.2 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE34018 WBGene00009664 isocitrate dehydrogenase status:Confirmed UniProt:Q93714 protein_id:CAB02111.2| [wormORF-contam.fasta]
  • Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial precursor (Isocitric dehydrogenase) (NAD(+)-specific ICDH) [nr-271106-contam.fasta]
  • Hypothetical protein F43G9.1 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • F43G9.1 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE34018 WBGene00009664 locus:idha-1 isocitrate dehydrogenase status:Confirmed UniProt:Q93714 protein_id:CAB02111.2 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • CE34018 WBGene00009664 locus:idha-1 status:Confirmed UniProt:Q93714 protein_id:CAB02111.2 Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial [wormpep246-ecoli-contam.fasta]
    • Organism: Caenorhabditis elegans
    Length: 358 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IEALink to PubMed article]
    mitochondrion [IEALink to PubMed article]
    Biological Process: locomotory behavior [IMPLink to PubMed article]
    hermaphrodite genitalia development [IMPLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed articleLink to PubMed article]
    positive regulation of growth rate [IMPLink to PubMed article]
    metabolic process [IEALink to PubMed article]
    leucine biosynthetic process [IEALink to PubMed article]
    tricarboxylic acid cycle [IEALink to PubMed article]
    positive regulation of multicellular organism growth [IMPLink to PubMed article]
    reproduction [IMPLink to PubMed article]
    Molecular Function: isocitrate dehydrogenase (NAD+) activity [IEALink to PubMed article]
    oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [IEALink to PubMed article]
    NAD or NADH binding [IEALink to PubMed article]
    isocitrate dehydrogenase (NADP+) activity [IEALink to PubMed article]
    tartrate dehydrogenase activity [IEALink to PubMed article]
    3-isopropylmalate dehydrogenase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLGKCIKKAS STVGQSIRYS SGDVRRVTLI PGDGIGPEIS ASVQKIFEAA DAPIAWDPVD  60
   61 VTPVKGRDGV FRIPSRCIEL MHANKVGLKG PLETPIGKGH RSLNLAVRKE FSLYANVRPC 120
  121 RSLEGHKTLY DNVDVVTIRE NTEGEYSGIE HEIVPGVVQS IKLITETASR NVASFAFEYA 180
  181 RQNGRKVVTA VHKANIMRQS DGLFLSICRE QAALYPDIKF KEAYLDTVCL NMVQDPSQYD 240
  241 VLVMPNLYGD ILSDLCAGLV GGLGVTPSGN IGKGAAVFES VHGTAPDIAG QDKANPTALL 300
  301 LSAVMMLRYM NLPQHAARIE KAVFDAIADG RAKTGDLGGT GTCSSFTADV CARVKDLE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run hcp-1 hcp1 IP from december2004 Cheeseman, I.M., et al. (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..358] PSI-BLAST 107.0 No description for 2d1cA was found.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle