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Protein Overview: rgef-1

General Information:
Name(s) found: rgef-1 / CE34003 [WormBase]
Description(s) found:
Found 15 descriptions.
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  • WBGene00009100 locus:rgef-1 status:Partially_confirmed UniProt:Q19770 protein_id:CAA94755.3 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 654 amino acids

    Gene Ontology:
    Cellular Component: intracellular [IEALink to PubMed article]
    Biological Process: regulation of small GTPase mediated signal transduction [IEALink to PubMed article]
    small GTPase mediated signal transduction [IEALink to PubMed article]
    Molecular Function: calcium ion binding [IEALink to PubMed article]
    guanyl-nucleotide exchange factor activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSKVEEDQH QELLTEDQLV ARCVECFDVD EEDEVEDIEF VDALFLSHQW LSDSLSLITH  60
   61 FVNFYQETRN VEQREAVCRA VSFWIEKFPM HFDAQPQVCA QVVRLKTIAE DINENIRNGL 120
  121 DVSALPSFAW LRAVSVRNPL AKQTAFSLSF VQASPSDIST SLSHIDYRVL SRISITELKQ 180
  181 YVKDGHLRSC PMLERSISVF NNLSNWVQCM ILNKTTPKER AEILVKFVHV AKHLRKINNF 240
  241 NTLMSVVGGI THSSVARLAK TYAVLSNDIK KELTQLTNLL SAQHNFCEYR KALGACNKKF 300
  301 RIPIIGVHLK DLVAINCSGA NFEKTKCISS DKLVKLSKLL SNFLVFNQKG HNLPEMNMDL 360
  361 INTLKVSLDI RYNDDDIYEL SLRREPKTFM NFEPSRGLVF AEWASGVTVA PDNATVSKHI 420
  421 SAMVDAVFKH YDHDRDGFIS QEEFQLIAGN FPFIDAFVNI DVDMDGQISK DELKTYFMAA 480
  481 NKNTKDLRRG FKHNFHETTF LTPTTCNHCN KLLWGILRQG FKCKDCGLAV HSCCKSNAVA 540
  541 ECRRKSSSNL TRAAEWFASP RGSMRSRIIN TCKRSSRPRT VSAVVTSPTT EKPTCSTKLS 600
  601 PPKLKDIRPQ SESTEYYNSG STPDEEIGLV SLACEEVFED DDLADISSAS YRTA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..420] PSI-BLAST 67.522879 No description for 2ii0A was found.
    2 View Details [421..654] PSI-BLAST 23.0 Crystal Structure of the Human Beta2-Chimaerin

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • GTPase regulator activity
    		•  2.70614727793157 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  2.68579854252375 bayes_pls_golite062009
  • binding
    		•  2.15139804299723 bayes_pls_golite062009
  • guanyl-nucleotide exchange factor activity
    		•  2.06038764955701 bayes_pls_golite062009
  • enzyme regulator activity
    		•  1.9750017471254 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  1.95738547986197 bayes_pls_golite062009
  • protein binding
    		•  1.29100556128076 bayes_pls_golite062009
  • signal transducer activity
    		•  1.25507073225414 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.25507073225414 bayes_pls_golite062009
  • Ras GTPase activator activity
    		•  1.09070479183477 bayes_pls_golite062009
  • Ras guanyl-nucleotide exchange factor activity
    		•  0.958295643211986 bayes_pls_golite062009
  • GTPase activator activity
    		•  0.717730683557543 bayes_pls_golite062009
  • enzyme activator activity
    		•  0.298334474872045 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.0455432286632499 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle