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Protein Overview: cdka-1

General Information:
Name(s) found: cdka-1 / CE33707 [WormBase]
Description(s) found:
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  • WBGene00011955 locus:cdka-1 Cyclin-dependent kinase 5 activator 1 status:Confirmed UniProt:Q22695 protein_id:CAA86458.2 [WormBase]
  • gi|71991496|ref|NP_497951.2| Cyclin-Dependent Kinase 5 Activating protein homolog family member (cdka-1) [Caenorhabditis elegans] [NCBI NR]
  • gi|44889062|sp|Q22695.2|CD5R1_CAEEL RecName: Full=Cyclin-dependent kinase 5 activator 1 [NCBI NR]
  • gi|29603358|emb|CAA86458.2| C. elegans protein T23F11.3a, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • gi|133901750|ref|NP_001076649.1| Cyclin-Dependent Kinase 5 Activating protein homolog family member (cdka-1) [Caenorhabditis elegans] [NCBI NR]
  • (Q22695) Hypothetical protein T23F11.3 in chromosome III [Swiss-Prot]
  • Cyclin-dependent kinase 5 activator 1 OS=Caenorhabditis elegans GN=cdka-1 PE=3 SV=2 [Swiss-Prot]
  • [wormpep104.fasta]
  • Hypothetical protein T23F11.3 [Caenorhabditis elegans]gi|44889062|sp|Q22695|YOP3_CAEEL Hypothetical protein T23F11.3 in chromosome III [nrdb_11152004_Chlamydomonas]
  • CE33707 WBGene00011955 locus:cdka-1 status:Confirmed SW:Q22695 protein_id:CAA86458.2 [wormpep150.fasta]
  • 33707 WBGene00011955 status:Partially_confirmed SW:Q22695 protein_id:CAA86458.2 [wormpep130-phg-ecoli-orf-rand.fasta]
  • CE33707 WBGene00011955 status:Partially_confirmed SW:Q22695 protein_id:CAA86458.2 [wormpep132.fasta]
  • 33707 WBGene00011955 locus:cdka-1 status:Confirmed SW:Q22695 protein_id:CAA86458.2 [wormpep150-phg-orf-ecoli-rand.fasta]
  • CE33707 WBGene00011955 status:Confirmed SW:Q22695 protein_id:CAA86458.2 [WormBase_C-elegans_na_01-20-2005_combined_reversed.fasta]
  • status:Partially_confirmed TN:CAA86458 protein_id:CAA86458.2 [wormpep115.fasta.reversed]
  • CE33707 WBGene00011955 locus:cdka-1 status:Confirmed UniProt:Q22695 protein_id:CAA86458.2 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE33707 WBGene00011955 locus:cdka-1 status:Confirmed UniProt:Q22695 protein_id:CAA86458.2| [wormORF-contam.fasta]
  • Cyclin-dependent kinase 5 activator 1 [nr-271106-contam.fasta]
  • Hypothetical protein T23F11.3a [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Cyclin-Dependent Kinase 5 Activating protein homolog family member (cdka-1) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE33707 WBGene00011955 locus:cdka-1 status:Confirmed UniProt:Q22695 protein_id:CAA86458.2 Cyclin-dependent kinase 5 activator 1 [wormpep246-ecoli-contam.fasta]
    • Organism: Caenorhabditis elegans
    Length: 356 amino acids

    Gene Ontology:
    Cellular Component: cyclin-dependent protein kinase 5 holoenzyme complex [IEALink to PubMed article]
    Biological Process: synaptic vesicle transport [IMPLink to PubMed article]
    synaptic transmission, GABAergic [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: cyclin-dependent protein kinase 5 activator activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGANLTSPLP HHHRTQTTSV CNHLFSPGDG GPTFAPQRDS NTSSRSSSNA KESVLMQGWN  60
   61 WSKRNIQPVM SRRSLPKSGS SSEATSSKSS DSLVSFTRNV STSTSSQYGK ISISLDRNQN 120
  121 YKSVPRPSDT TTIIPNYYSL REEFRRGLQI NTRQDLVNNN LASNDLSVIG SPKHVPRPRS 180
  181 VLRDDNANCD ISPIAEQENV PSEASTSELL RGLGIFISNN CDVSDFDPAH LVTWLRSVDR 240
  241 SLLLQGWQDI AFINPANLVF IFLLVRDVLP DERHLIHTLE ELHAWILSCL YVSYSYMGNE 300
  301 ISYPLKPFLI GNDRNTFWNR CVAMVTSHSR QMLLLNSSST FFSEVFTDLK HCSSSE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..169] Pfam 13.853872 No description for PF03261.6 was found. No confident structure predictions are available.
    2 View Details [170..356] PSI-BLAST 89.522879 Structural mechanism for the inhibition of CDK5-p25 by roscovitine, aloisine and indirubin.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  0.856796143703865 bayes_pls_golite062009
  • protein binding
    		•  0.73326264902081 bayes_pls_golite062009
  • kinase regulator activity
    		•  0.29156514721728 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.27414343875363 bayes_pls_golite062009
  • protein kinase regulator activity
    		•  0.19903417452788 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.81

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle