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Protein Overview: unc-78

General Information:
Name(s) found: unc-78 / CE33554 [WormBase]
Description(s) found:
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  • WBGene00006810 locus:unc-78 Actin-interacting protein 1 status:Confirmed UniProt:Q11176 protein_id:CCD63030.1 [WormBase]
  • gi|71982270|ref|NP_001024357.1| UNCoordinated family member (unc-78) [Caenorhabditis elegans] [NCBI NR]
  • gi|28894846|gb|AAO61444.1| Uncoordinated protein 78, isoform b [Caenorhabditis elegans] [NCBI NR]
  • [wormpep104.fasta]
  • Uncoordinated protein 78, isoform b [Caenorhabditis elegans] [nrdb_11152004_Chlamydomonas]
  • CE33554 WBGene00006810 locus:unc-78 status:Confirmed TR:Q86GT5 protein_id:AAO61444.1 [wormpep150.fasta]
  • 33554 WBGene00006810 locus:unc-78 status:Partially_confirmed TR:Q86GT5 protein_id:AAO61444.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • CE33554 WBGene00006810 locus:unc-78 status:Partially_confirmed TR:Q86GT5 protein_id:AAO61444.1 [wormpep132.fasta]
  • 33554 WBGene00006810 locus:unc-78 status:Confirmed TR:Q86GT5 protein_id:AAO61444.1 [wormpep150-phg-orf-ecoli-rand.fasta]
  • locus:unc-78 status:Partially_confirmed TR:Q86GT5 protein_id:AAO61444.1 [wormpep115.fasta.reversed]
  • CE33554 WBGene00006810 locus:unc-78 status:Confirmed UniProt:WDR1_CAEEL protein_id:AAO61444.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE33554 WBGene00006810 locus:unc-78 status:Confirmed UniProt:WDR1_CAEEL protein_id:AAO61444.1| [wormORF-contam.fasta]
  • UNCoordinated family member (unc-78) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CE33554 WBGene00006810 locus:unc-78 status:Confirmed SW:Q11176 protein_id:AAO61444.1 [WormBase_C-elegans_wp180_08-19-2007_reversed.fasta]
  • CE33554 WBGene00006810 locus:unc-78 status:Confirmed UniProt:Q11176 protein_id:AAO61444.1 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE33554 WBGene00006810 locus:unc-78 status:Confirmed UniProt:Q11176 protein_id:CCD63030.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • CE33554 WBGene00006810 locus:unc-78 status:Confirmed UniProt:Q11176 protein_id:CCD63030.1 Actin-interacting protein 1 [wormpep246-ecoli-contam.fasta]
  • Isoform of Q11176, Isoform b of Actin-interacting protein 1 OS=Caenorhabditis elegans GN=unc-78 [CAEEL.fasta.20160308]
    • Organism: Caenorhabditis elegans
    Length: 517 amino acids

    Gene Ontology:
    Cellular Component: sarcoplasm [IDALink to PubMed article]
    actomyosin, actin part [IDALink to PubMed article]
    Biological Process: barbed-end actin filament capping [ISSLink to PubMed article]
    locomotory behavior [IMPLink to PubMed articleLink to PubMed article]
    regulation of locomotion [IGI][IMP]
    negative regulation of actin filament polymerization [IDALink to PubMed article]
    positive regulation of actin filament depolymerization [IDALink to PubMed article]
    nematode larval development [IMPLink to PubMed article]
    skeletal muscle thin filament assembly [IMP]
    positive regulation of growth rate [IMPLink to PubMed article]
    oviposition [IMPLink to PubMed article]
    positive regulation of locomotion [IMPLink to PubMed articleLink to PubMed article]
    Molecular Function: actin binding [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEFSQTALF PSLPRTARGT AVVLGNTPAG DKIQYCNGTS VYTVPVGSLT DTEIYTEHSH  60
   61 QTTVAKTSPS GYYCASGDVH GNVRIWDTTQ TTHILKTTIP VFSGPVKDIS WDSESKRIAA 120
  121 VGEGRERFGH VFLFDTGTSN GNLTGQARAM NSVDFKPSRP FRIISGSDDN TVAIFEGPPF 180
  181 KFKSTFGEHT KFVHSVRYNP DGSLFASTGG DGTIVLYNGV DGTKTGVFED DSLKNVAHSG 240
  241 SVFGLTWSPD GTKIASASAD KTIKIWNVAT LKVEKTIPVG TRIEDQQLGI IWTKQALVSI 300
  301 SANGFINFVN PELGSIDQVR YGHNKAITAL SSSADGKTLF SADAEGHINS WDISTGISNR 360
  361 VFPDVHATMI TGIKTTSKGD LFTVSWDDHL KVVPAGGSGV DSSKAVANKL SSQPLGLAVS 420
  421 ADGDIAVAAC YKHIAIYSHG KLTEVPISYN SSCVALSNDK QFVAVGGQDS KVHVYKLSGA 480
  481 SVSEVKTIVH PAEITSVAFS NNGAFLVATD QSRKVSF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..517] PSI-BLAST 87.69897 Actin interacting protein 1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • actin binding
    		•  3.86142918698875 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  3.1056443224755 bayes_pls_golite062009
  • binding
    		•  2.2778252170547 bayes_pls_golite062009
  • actin filament binding
    		•  2.0735069176589 bayes_pls_golite062009
  • protein binding
    		•  1.42618832381942 bayes_pls_golite062009
  • myosin heavy chain kinase activity
    		•  1.24520283111044 bayes_pls_golite062009
  • transporter activity
    		•  1.21549336905926 bayes_pls_golite062009
  • myosin binding
    		•  0.989691178611801 bayes_pls_golite062009
  • tubulin binding
    		•  0.968047176592527 bayes_pls_golite062009
  • microtubule binding
    		•  0.834073483714259 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.734793983890004 bayes_pls_golite062009
  • dynein binding
    		•  0.41765917405931 bayes_pls_golite062009
  • receptor binding
    		•  0.364508343879101 bayes_pls_golite062009
    		• 0.13154833491231 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.118975415284669 bayes_pls_golite062009
  • transcription factor binding
    		•  0.0250316290871848 bayes_pls_golite062009
  • myosin II binding
    		•  0.0145748031956598 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.69

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle