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Protein Overview: obr-3

General Information:
Name(s) found: obr-3 / CE31673 [WormBase]
Description(s) found:
Found 16 descriptions.
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  • WBGene00014215 locus:obr-3 status:Partially_confirmed UniProt:Q8MPR9 protein_id:CAD44161.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 770 amino acids

    Gene Ontology:
    Cellular Component: integral to membrane [IEALink to PubMed article]
    Biological Process: regulation of multicellular organism growth [IMPLink to PubMed article]
    transforming growth factor beta receptor signaling pathway [IMPLink to PubMed article]
    steroid metabolic process [IEALink to PubMed article]
    Molecular Function: protein binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLERRKERKL TITSPNEDMR IVEPPAHKQR RASLSVAYHR LLSFSSSPIK KQKKEYRDEK  60
   61 KRVNDELLSA LRDPTVVVMA DTLKIRGALK RWNRYYCVLK PGLLILYKHK KADRGDWVGT 120
  121 VLLNHCELIE RPSKKDGFCF KLFHPMDMSI WGNRGPLGQS FGSFTLNPLN TSFLICRAPS 180
  181 DQAGRCWMDA LELSFKCTGL LKKTMNELDD KNGDSSMNDG QRDESRMSRD SDGDDTRELA 240
  241 VSETDAEKHF QEIDDVQDED HEDGKMSETS DTIREAFTES AWIPSPKEVF GPDGSLTEEV 300
  301 GEENKSLIWT LLKQIRPGMD LSKVVLPTFI LEPRSFLEKL ADYYYHADLI SEAVAEPDPF 360
  361 QRIVKVTKFF LSGFYKKPKG LKKPYNPILG ETFRCKWEHP DGSTTFYMAE QVSHHPPVSS 420
  421 LFITNRKAGF NISGTILAKS KYYGNSLSAI LAGKLRLTLL NLGETYIVNL PYANCKGIMI 480
  481 GTMTMELGGE VNIECEKTGY RTTLDFKLKP MLGGAYNQIE GSIKYGSDRL ASIEGAWDGV 540
  541 IRIKGPDGKK ELWNPTPEVI KTRLPRYEIN MDEQGEWESA KLWRHVTEAI SNEDQYKATE 600
  601 EKTALENDQR ARAKSGIPHE TKFFKKQHGD DYVYIHADYR PWDNNNDIQQ IENNYVVKTI 660
  661 SRHSKRKTGN SEQLGSDNTS EASESDEEVI EPKIKKKEIV PAKSKPITPE VADERIKEME 720
  721 RKFELAIRRM EAANERQSSR TLNAIQSTLL FVFVVTSVVQ SIFMFFMLRK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..186] PSI-BLAST 30.0 Solution Structure of the Pleckstrin Homology Domain of Oxysterol-Binding Protein-Related Protein 8 (KIAA1451 Protein)
    2 View Details [187..295] deduced N/A No confident structure predictions are available.
    3 View Details [296..642] PSI-BLAST 74.522879 Structure of yeast oxysterol binding protein Osh4 in complex with 7-hydroxycholesterol
    4 View Details [643..770] MSA 1.16498 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  2.86147407357315 bayes_pls_golite062009
  • protein binding
    		•  2.12168271674167 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.34134699517825 bayes_pls_golite062009
  • signal transducer activity
    		•  1.34134699517825 bayes_pls_golite062009
  • transporter activity
    		•  1.28986800087234 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.10315055505849 bayes_pls_golite062009
  • phospholipid binding
    		•  1.09683218092034 bayes_pls_golite062009
  • receptor activity
    		•  1.02045773197699 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.990048359575281 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.870327630723237 bayes_pls_golite062009
  • DNA binding
    		•  0.856684960067851 bayes_pls_golite062009
  • receptor binding
    		•  0.84825890337371 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.79883446648737 bayes_pls_golite062009
  • oxysterol binding
    		•  0.792005176778139 bayes_pls_golite062009
  • clathrin binding
    		•  0.768496041585918 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase signaling protein activity
    		•  0.740468760397673 bayes_pls_golite062009
  • structural molecule activity
    		•  0.731721560204237 bayes_pls_golite062009
  • phosphoinositide binding
    		•  0.71817045430443 bayes_pls_golite062009
  • protein domain specific binding
    		•  0.51731521446502 bayes_pls_golite062009
  • insulin receptor binding
    		•  0.34801451897076 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.268141992393579 bayes_pls_golite062009
  • protein complex binding
    		•  0.22543440052247 bayes_pls_golite062009
  • lipid binding
    		•  0.179561240451969 bayes_pls_golite062009
  • SH2 domain binding
    		•  0.13752708274522 bayes_pls_golite062009
  • hydrolase activity
    		•  0.0955091952069367 bayes_pls_golite062009
  • actin binding
    		•  0.0485598963526399 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.00282726023356339 bayes_pls_golite062009
    2 No functions predicted.
    3
    Term Confidence Notes
  • oxysterol binding
    		•  5.62675037461468 bayes_pls_golite062009
  • sterol binding
    		•  4.18891468109664 bayes_pls_golite062009
    		• 3.02967613614595 bayes_pls_golite062009
  • steroid binding
    		•  2.54679035876403 bayes_pls_golite062009
  • phosphoinositide binding
    		•  2.2725849852584 bayes_pls_golite062009
  • binding
    		•  2.10831141109811 bayes_pls_golite062009
  • phospholipid binding
    		•  2.08170907241909 bayes_pls_golite062009
  • lipid binding
    		•  1.8520231230392 bayes_pls_golite062009
  • cholesterol binding
    		•  0.644339278395346 bayes_pls_golite062009
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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