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Protein Overview: hif-1

General Information:
Name(s) found: hif-1 / CE32019 [WormBase]
Description(s) found:
Found 16 descriptions.
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  • WBGene00001851 locus:hif-1 Hypoxia-inducible factor 1 status:Confirmed UniProt:G5EGD2 protein_id:CAD54167.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 503 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article][IEALink to PubMed article]
    Biological Process: response to hypoxia [IMPLink to PubMed article]
    signal transduction [IEALink to PubMed article]
    regulation of transcription, DNA-dependent [IEALink to PubMed article]
    regulation of transcription [IEALink to PubMed article]
    Molecular Function: transcription factor activity [ISSLink to PubMed article]
    transcription regulator activity [IEALink to PubMed article]
    signal transducer activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRDSEYLDR KYTESPMGAF TTRHTCDMRI TFVSDKFNYI LKSELKTLMG TSFYELVHPA  60
   61 DMMIVSKSMK ELFAKGHIRT PYYRLIAAND TLAWIQTEAT TITHTTKGQK GQYVICVHYV 120
  121 LGIQGAEESL VVCTDSMPAG MQVDIKKEVD DTRDYIGRQP EIVECVDFTP LIEPEDPFDT 180
  181 VIEPVVGGEE PVKQADMGAR KNSYDDVLQW LFRDQPSSPP PARYRSADRF RTTEPSNFGS 240
  241 ALASPDFMDS SSRTSRPKTS YGRRAQSQGS RTTGSSSTSA SATLPHSANY SPLAEGISQC 300
  301 GLNSPPSIKS GQVVYGDARS MGRSCDPSDS SRRFSALSPS DTLNVSSTRG INPVIGSNDV 360
  361 FSTMPFADSI AIAERIDSSP TLTSGEPILC DDLQWEEPDL SCLAPFVDTY DMMQMDEGLP 420
  421 PELQALYDLP DFTPAVPQAP AARPVHIDRS PPAKRMHQSG PSDLDFMYTQ HYQPFQQDET 480
  481 YWQGQQQQNE QQPSSYSPFP MLS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..137] PSI-BLAST 36.0 NMR structure of the C-terminal PAS domain of HIF2a
    2 View Details [138..371] deduced N/A No confident structure predictions are available.
    3 View Details [372..503] MSA 4.220996 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  0.438711522487185 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle