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Protein Overview: egl-4

General Information:
Name(s) found: egl-4 / CE31541 [WormBase]
Description(s) found:
Found 18 descriptions.
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  • WBGene00001173 locus:egl-4 cGMP-dependent protein kinase egl-4 status:Confirmed UniProt:O76360 protein_id:CCD71861.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 749 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IEALink to PubMed article]
    cAMP-dependent protein kinase complex [IEALink to PubMed article]
    Biological Process: signal transduction [IEALink to PubMed article]
    protein amino acid phosphorylation [IEALink to PubMed article]
    Molecular Function: ATP binding [IEALink to PubMed article]
    protein tyrosine kinase activity [IEALink to PubMed article]
    zinc ion binding [IEALink to PubMed article]
    non-membrane spanning protein tyrosine kinase activity [IEALink to PubMed article]
    protein kinase activity [IEALink to PubMed article]
    protein serine/threonine kinase activity [IEALink to PubMed article]
    cAMP-dependent protein kinase regulator activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYGSSRHHMD SFSSNDGGAF LVQVGTRTFE AHELQKLIPQ LEEAISRKDA QLRQQQTIVE  60
   61 GHIKRISELE GEVTTLQREC DKLRSVLEQK AQSAASPGGQ PPSPSPRTDQ LGNDLQQKAV 120
  121 LPADGVQRAK KIAVSAEPTN FENKPATLQH YNKTVGAKQM IRDAVQKNDF LKQLAKEQII 180
  181 ELVNCMYEMR ARAGQWVIQE GEPGDRLFVV AEGELQVSRE GALLGKMRAG TVMGELAILY 240
  241 NCTRTASVQA LTDVQLWVLD RSVFQMITQR LGMERHSQLM NFLTKVSIFQ NLSEDRISKM 300
  301 ADVMDQDYYD GGHYIIRQGE KGDAFFVINS GQVKVTQQIE GETEPREIRV LNQGDFFGER 360
  361 ALLGEEVRTA NIIAQAPGVE VLTLDRESFG KLIGDLESLK KDYGDKERLA QVVREPPSPV 420
  421 KIVDDFREEF AQVTLKNVKR LATLGVGGFG RVELVCVNGD KAKTFALKAL KKKHIVDTRQ 480
  481 QEHIFAERNI MMETSTDWIV KLYKTFRDQK FVYMLLEVCL GGELWTTLRD RGHFDDYTAR 540
  541 FYVACVLEGL EYLHRKNIVY RDLKPENCLL ANTGYLKLVD FGFAKKLASG RKTWTFCGTP 600
  601 EYVSPEIILN KGHDQAADYW ALGIYICELM LGRPPFQASD PMKTYTLILK GVDALEIPNR 660
  661 RIGKTATALV KKLCRDNPGE RLGSGSGGVN DIRKHRWFMG FDWEGLRSRT LKPPILPKVS 720
  721 NPADVTNFDN YPPDNDVPPD EFSGWDEGF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run hcp-1 hcp1 IP from december2004 Cheeseman, I.M., et al. (2005)
    View Run hcp-2 hcp2 ip from december Cheeseman, I.M., et al. (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..101] PSI-BLAST 5.69897 Solution structure of the docking and dimerization domain of the type I alpha regulatory subunit of protein kinase A (RIalpha D/D)
    2 View Details [102..310] PSI-BLAST 43.30103 REGULATORY SUBUNIT OF CAMP DEPENDENT PROTEIN KINASE
    3 View Details [311..687] PSI-BLAST 44.09691 No description for 2ozoA was found.
    4 View Details [688..749] PSI-BLAST 87.69897 cAMP-dependent PK, catalytic subunit


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

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    Created and Maintained by: Michael Riffle