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Protein Overview: unc-60

General Information:
Name(s) found: unc-60 / CE31893 [WormBase]
Description(s) found:
Found 20 descriptions.
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  • WBGene00006794 locus:unc-60 Actin-depolymerizing factor 1, isoforms a\/b status:Partially_confirmed UniProt:Q07750 protein_id:CCD67022.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 212 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    actin filament [IDALink to PubMed article]
    intracellular [IEALink to PubMed article]
    myofibril [IDALink to PubMed article]
    Biological Process: embryonic development [IMPLink to PubMed article]
    locomotory behavior [IMPLink to PubMed article]
    hermaphrodite genitalia development [IMPLink to PubMed article]
    locomotion [IMPLink to PubMed article]
    nematode larval development [IMPLink to PubMed article]
    actin filament depolymerization [IMPLink to PubMed article]
    skeletal muscle thin filament assembly [IMPLink to PubMed article]
    reproduction [IMPLink to PubMed article]
    Molecular Function: actin filament binding [IDALink to PubMed article]
    growth factor activity [IEALink to PubMed article]
    actin binding [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSGVMVDPD VQTSFQKLSE GRKEYRYIIF KIDENKVIVE AAVTQDQLGI TGDDYDDSSK  60
   61 AAFDKFVEDV KSRTDNLTDC RYAVFDFKFT CSRVGAGTSK MDKIIFLQIC PDGASIKKKM 120
  121 VYASSAAAIK TSLGTGKILQ FQVSDESEMS HKELLNNCPD NAPVRRRMLY ASSVRALKAS 180
  181 LGLESLFQVQ ASEMSDLDEK SVKSDLMSNQ RI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..149] PSI-BLAST 33.0 Cofilin (actin depolymerizing factor, ADF)
    2 View Details [150..212] FFAS03 2.72 Adf-H domain of twinfilin isoform-1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • actin binding
    		•  7.52071741004022 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  6.04859625643932 bayes_pls_golite062009
  • actin filament binding
    		•  5.45532510538573 bayes_pls_golite062009
  • binding
    		•  2.84811181543046 bayes_pls_golite062009
  • protein binding
    		•  1.87981807141519 bayes_pls_golite062009
  • phosphatidylinositol-4,5-bisphosphate binding
    		•  1.3406661967545 bayes_pls_golite062009
  • phosphatidylserine binding
    		•  0.588992286163708 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.482954032096802 bayes_pls_golite062009
  • actin monomer binding
    		•  0.224304003054399 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle