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Protein Overview: lip-1

General Information:
Name(s) found: lip-1 / CE31151 [WormBase]
Description(s) found:
Found 17 descriptions.
SHOW ALL
  • WBGene00003043 locus:lip-1 status:Confirmed UniProt:O44128 protein_id:CCD63076.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 369 amino acids

    Gene Ontology:
    Cellular Component: plasma membrane [IDALink to PubMed article]
    Biological Process: regulation of cell fate specification [IGILink to PubMed article]
    negative regulation of MAP kinase activity [IGILink to PubMed articleLink to PubMed article][IMPLink to PubMed article]
    Notch signaling pathway [IGILink to PubMed article]
    negative regulation of Ras protein signal transduction [IGILink to PubMed articleLink to PubMed article]
    oocyte development [IGILink to PubMed article][IMPLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed article]
    protein amino acid dephosphorylation [IEALink to PubMed article]
    dephosphorylation [IEALink to PubMed article]
    regulation of vulval development [IGILink to PubMed article]
    negative regulation of meiotic cell cycle [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: protein tyrosine phosphatase activity [IEALink to PubMed article]
    phosphatase activity [IEALink to PubMed article]
    protein tyrosine/serine/threonine phosphatase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTHLPSTSQ NGEEISAEQF NRIFHERNVI VLDCRSNGDS VKRANRFFCS LRLPALLQRR  60
   61 LMGGSMRLST VPDLKDLNNS PDQCPEVLLI PGDSEQDEQL SAALARNLKS NHYRHFVLGE 120
  121 PVKTLLSQFP TLRDAADENW NTTFQMNSMP GQASGQQASS GPLLNLNQLR LEGEDQGGKQ 180
  181 RAEFPVKLTN FLYLGNAETA KNRDVLKKYS ISHVINVTSN LPNTFEEDPN MRYLRISADD 240
  241 NASHNLTKFF PEAISFIDDA RRNDSACLVH CLAGISRSVT ICLAYLMKTE MCTLDSAYEW 300
  301 VQKRNASIAP NFHFMGQLTD YEKMLGLNSN RVGVSRQAVN FDVHFFCIFK LKKKEENSPE 360
  361 SRILAETAV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..160] PSI-BLAST 21.522879 Erk2 binding domain of Mapk phosphatase mkp-3
    2 View Details [161..369] PSI-BLAST 38.69897 No description for 2hxpA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphoprotein phosphatase activity
    		•  4.79074052803751 bayes_pls_golite062009
  • phosphatase activity
    		•  3.95816335500141 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  3.78173224935267 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  3.24681684836294 bayes_pls_golite062009
  • protein tyrosine phosphatase activity
    		•  2.84204105189999 bayes_pls_golite062009
  • hydrolase activity
    		•  2.12055507229256 bayes_pls_golite062009
  • binding
    		•  1.72957395505299 bayes_pls_golite062009
  • protein binding
    		•  1.56606332199727 bayes_pls_golite062009
  • catalytic activity
    		•  0.687308230067573 bayes_pls_golite062009
  • transferase activity
    		•  0.302497611306574 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle