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Protein Overview: aco-2

General Information:
Name(s) found: aco-2 / CE30144 [WormBase]
Description(s) found:
Found 20 descriptions.
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  • WBGene00000041 locus:aco-2 Probable aconitate hydratase, mitochondrial status:Partially_confirmed UniProt:P34455 protein_id:CCD63455.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 665 amino acids

    Gene Ontology:
    Cellular Component: 3-isopropylmalate dehydratase complex [IEALink to PubMed article]
    Biological Process: lysine biosynthetic process [IEALink to PubMed article]
    locomotory behavior [IMPLink to PubMed articleLink to PubMed article]
    hermaphrodite genitalia development [IMPLink to PubMed article]
    nematode larval development [IMPLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed articleLink to PubMed article]
    metabolic process [IEALink to PubMed article]
    leucine biosynthetic process [IEALink to PubMed article]
    tricarboxylic acid cycle [IEALink to PubMed article]
    cellular amino acid biosynthetic process [IEALink to PubMed article]
    reproduction [IMPLink to PubMed article]
    growth [IMPLink to PubMed article]
    Molecular Function: hydro-lyase activity [IEALink to PubMed article]
    homoaconitate hydratase activity [IEALink to PubMed article]
    4 iron, 4 sulfur cluster binding [IEALink to PubMed article]
    3-isopropylmalate dehydratase activity [IEALink to PubMed article]
    aconitate hydratase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNSLLRLSHL AGPAHYRALH SSSSIWSKVA ISKFEPKSYL PYEKLSQTVK IVKDRLKRPL  60
   61 TLSEKILYGH LDQPKTQDIE RGVSYLRLRP DRVAMQDAVD VMADIPWELK CPKVIGIKLT 120
  121 GKLNGWTSAK DVILKVADIL TVKGGTGAIV EYFGPGVDSI SATGMGTICN MGAEIGATTS 180
  181 VFPYNESMYK YLEATGRKEI AEEARKYKDL LTADDGANYD QIIEINLDTL TPHVNGPFTP 240
  241 DLASSIDKLG ENAKKNGWPL DVKVSLIGSC TNSSYEDMTR AASIAKQALD KGLKAKTIFT 300
  301 ITPGSEQVRA TIERDGLSKI FADFGGMVLA NACGPCIGQW DRQDVKKGEK NTIVTSYNRN 360
  361 FTGRNDANPA THGFVTSPDI TTAMAISGRL DFNPLTDELT AADGSKFKLQ APTGLDLPPK 420
  421 GYDPGEDTFQ APSGSGQVDV SPSSDRLQLL SPFDKWDGKD LEDMKILIKV TGKCTTDHIS 480
  481 AAGPWLKYRG HLDNISNNLF LTAINADNGE MNKVKNQVTG EYGAVPATAR KYKADGVRWV 540
  541 AIGDENYGEG SSREHAALEP RHLGGRAIIV KSFARIHETN LKKQGMLPLT FANPADYDKI 600
  601 DPSDNVSIVG LSSFAPGKPL TAIFKKTNGS KVEVTLNHTF NEQQIEWFKA GSALNRMKEV 660
  661 FAKSK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..665] PSI-BLAST 1000.0 STRUCTURE OF ACTIVATED ACONITASE. FORMATION OF THE (4FE-4S) CLUSTER IN THE CRYSTAL

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • aconitate hydratase activity
    		•  4.91219496433532 bayes_pls_golite062009
  • catalytic activity
    		•  2.77447238073741 bayes_pls_golite062009
  • hydro-lyase activity
    		•  2.59723655295015 bayes_pls_golite062009
  • carbon-oxygen lyase activity
    		•  2.42042556122269 bayes_pls_golite062009
  • lyase activity
    		•  1.70481477411474 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.87

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle