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Protein Overview: lin-3

General Information:
Name(s) found: lin-3 / CE30348 [WormBase]
Description(s) found:
Found 20 descriptions.
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  • WBGene00002992 locus:lin-3 Protein lin-3 status:Confirmed UniProt:Q03345 protein_id:CAD30434.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 423 amino acids

    Gene Ontology:
    Cellular Component: integral to plasma membrane [ISSLink to PubMed article]
    extracellular space [ISSLink to PubMed article]
    Biological Process: ovulation from ovarian follicle [IMPLink to PubMed article]
    positive regulation of vulval development [IMPLink to PubMed articleLink to PubMed articleLink to PubMed article]
    regulation of cell fate specification [IMPLink to PubMed article]
    inductive cell-cell signaling [IEPLink to PubMed article][IMPLink to PubMed article]
    nematode larval development [IMPLink to PubMed article]
    male genitalia development [IMPLink to PubMed article]
    epidermal growth factor receptor signaling pathway [IGILink to PubMed article][ISSLink to PubMed article]
    post-embryonic development [IMPLink to PubMed article]
    oviposition [IMPLink to PubMed articleLink to PubMed articleLink to PubMed article]
    gamete generation [IMPLink to PubMed article]
    reproduction [IMPLink to PubMed articleLink to PubMed articleLink to PubMed article]
    Molecular Function: epidermal growth factor receptor activating ligand activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRKMLLFCIL LLFMPQFTVS ESCLPSWFRQ ERSAPEQLQS AENAAENSGS VPPDTSRNSL  60
   61 ETNEIGDAPS STSTPETPTE TTISEAGDDE KRTEEVAKEL IEKEAEYEGE YEDEKVDEEV 120
  121 EEALKYNEDA TQDATSTLKP AVRKEIEKLK EAKCKDYCHH NATCHVEVIF REDRVSAVVP 180
  181 SCHCPQGWEG TRCDRHYVQA FYAPINGRYN QSSTSAIPAF AFLIVMLIMF ITIVVYAYRR 240
  241 MSKRSDDMTY TMSHMCPPEA FNVLKTPNGR HIPVHQIPSC SYTIPTPGTV PPNISSTPGS 300
  301 RIPTRQQAIR NNEQARNNFF SILRSQGTIP SRSINDDDTP KHYKSVPRVE VSAINYSGHI 360
  361 DFSTVSYQST ESEVSKASVT CPPPAHTVIN IELDSADTNF RSPSRSSGEQ GSPATCEPMI 420
  421 RHT

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..207] PSI-BLAST 7.0 Low density lipoprotein (LDL) receptor YWTD domain; Low density lipoprotein (LDL) receptor, different EGF domains; Ligand-binding domain of low-density lipoprotein receptor
    2 View Details [208..423] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • epidermal growth factor receptor binding
    		•  4.60166610111644 bayes_pls_golite062009
  • receptor binding
    		•  3.10014156620054 bayes_pls_golite062009
  • ErbB-2 class receptor binding
    		•  2.49988032150831 bayes_pls_golite062009
  • ErbB-3 class receptor binding
    		•  2.42594378586851 bayes_pls_golite062009
  • binding
    		•  2.33940742543305 bayes_pls_golite062009
  • protein binding
    		•  1.97546801934296 bayes_pls_golite062009
  • growth factor activity
    		•  1.86884324063738 bayes_pls_golite062009
  • signal transducer activity
    		•  1.66401431847753 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.66401431847753 bayes_pls_golite062009
  • transcription factor binding
    		•  0.795087651578297 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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