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Protein Overview: pole-2

General Information:
Name(s) found: pole-2 / CE29749 [WormBase]
Description(s) found:
Found 20 descriptions.
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  • WBGene00017237 locus:pole-2 Probable DNA polymerase epsilon subunit 2 status:Partially_confirmed UniProt:Q19196 protein_id:CCD67651.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 534 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEALink to PubMed article]
    Biological Process: locomotory behavior [IMPLink to PubMed article]
    hermaphrodite genitalia development [IMPLink to PubMed articleLink to PubMed article]
    morphogenesis of an epithelium [IMPLink to PubMed article]
    nematode larval development [IMPLink to PubMed article]
    DNA replication [IEALink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed articleLink to PubMed article]
    positive regulation of multicellular organism growth [IMPLink to PubMed article]
    growth [IMPLink to PubMed article]
    Molecular Function: DNA binding [IEALink to PubMed article]
    DNA-directed DNA polymerase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDTTAEENAL RREIVKTFQI HAFELKKEAV KLCVKLFLDH DKETRKKWTN KMIELLKKQT  60
   61 LQSSLISEEL IRDTFRQCKS KGTQDAGKLL NVFDAFSLQP YDFDADLRKM VLRKEKTSLA 120
  121 ADSSSFSHAA RQRFFIVKQR AMRCASLKNF KFTTCEILGS STKHLQSVVV LGMLTQQKAD 180
  181 CYHIEDLSGS VEVEFKEDTK FHHALFHEHS IAIFEGTFEN SVLTVNEVAM VPVESAEVTR 240
  241 KELSSNENWF GGDDKIAFRC SDRLRSALAK QEDTSLVFLS DVFLDDKKVM KAVFKLLQGY 300
  301 KDQPPVAIVF CGNFCSRPRQ TDTIDLLDRG FRWLANQLTP LRKDYEKTQF IFVPGPDDPF 360
  361 VDTVLPRPHL PSLLFKHISP IISCTFASNP CRIQFASQEI VVFRSDLIKK TCRHSINSIT 420
  421 VESIPSRYAR SVLSQAHLCP LPQHITPVLP DFSHSLSLHP LPDLLITADR FETFTEKVVG 480
  481 ADTIVSNPGS FSRSNYTFHV YYPCQNRVEA SQIPVSELDD HSNIKNVIIF FFLF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..119] deduced N/A No confident structure predictions are available.
    2 View Details [120..256] MSA 2.166982 View MSA. No confident structure predictions are available.
    3 View Details [257..534] PSI-BLAST 6.0 No description for 2dxlA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • hydrolase activity, acting on ester bonds
    		•  2.11518948144723 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.74872156325503 bayes_pls_golite062009
  • protein serine/threonine phosphatase activity
    		•  1.72108778738758 bayes_pls_golite062009
  • transferase activity
    		•  1.70522125323477 bayes_pls_golite062009
  • catalytic activity
    		•  1.39852585255405 bayes_pls_golite062009
  • phosphoprotein phosphatase activity
    		•  1.23036240099336 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  0.899406797746366 bayes_pls_golite062009
  • binding
    		•  0.852545739165539 bayes_pls_golite062009
  • phosphatase activity
    		•  0.76188635342041 bayes_pls_golite062009
  • protein binding
    		•  0.306836734324834 bayes_pls_golite062009
  • hydrolase activity
    		•  0.303024521214706 bayes_pls_golite062009
  • structural molecule activity
    		•  0.204234628453541 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle