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Protein Overview: CE30601

General Information:
Name(s) found: CE30601 [WormBase]
Description(s) found:
Found 21 descriptions.
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  • WBGene00015752 Probable protein disulfide-isomerase A4 status:Confirmed UniProt:P34329 protein_id:CCD64436.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 618 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum [IEALink to PubMed article]
    Biological Process: positive regulation of growth rate [IMPLink to PubMed articleLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed article]
    glycerol ether metabolic process [IEALink to PubMed article]
    cell redox homeostasis [IEALink to PubMed article]
    gamete generation [IMPLink to PubMed article]
    positive regulation of multicellular organism growth [IMPLink to PubMed article]
    Molecular Function: protein disulfide oxidoreductase activity [IEALink to PubMed article]
    electron carrier activity [IEALink to PubMed article]
    isomerase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMFDRRFFAL VVLLCVSAVR STEDASDDEL NYEMDEGVVV LTDKNFDAFL KKNPSVLVKF  60
   61 YAPWCGHCKH LAPEYEKASS KVSIPLAKVD ATVETELGKR FEIQGYPTLK FWKDGKGPND 120
  121 YDGGRDEAGI VEWVESRVDP NYKPPPEEVV TLTTENFDDF ISNNELVLVE FYAPWCGHCK 180
  181 KLAPEYEKAA QKLKAQGSKV KLGKVDATIE KDLGTKYGVS GYPTMKIIRN GRRFDYNGPR 240
  241 EAAGIIKYMT DQSKPAAKKL PKLKDVERFM SKDDVTIIGF FATEDSTAFE AFSDSAEMLR 300
  301 EEFKTMGHTS DPAAFKKWDA KPNDIIIFYP SLFHSKFEPK SRTYNKAAAT SEDLLAFFRE 360
  361 HSAPLVGKMT KKNAATRYTK KPLVVVYYNA DFSVQYREGS EYWRSKVLNI AQKYQKDKYK 420
  421 FAVADEEEFA KELEELGLGD SGLEHNVVVF GYDGKKYPMN PDEFDGELDE NLEAFMKQIS 480
  481 SGKAKAHVKS APAPKDDKGP VKTVVGSNFD KIVNDESKDV LIEFYAPWCG HCKSFESKYV 540
  541 ELAQALKKTQ PNVVLAKMDA TINDAPSQFA VEGFPTIYFA PAGKKSEPIK YSGNRDLEDL 600
  601 KKFMTKHGVK SFQKKDEL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..140] PSI-BLAST 29.221849 HUMAN PROTEIN DISULFIDE ISOMERASE, NMR, 40 STRUCTURES
    2 View Details [141..618] PSI-BLAST 69.39794 Crystal Structure of Yeast Protein Disulfide Isomerase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein disulfide isomerase activity
    		•  4.54149370439152 bayes_pls_golite062009
  • intramolecular oxidoreductase activity, transposing S-S bonds
    		•  4.54149370439152 bayes_pls_golite062009
  • intramolecular oxidoreductase activity, interconverting keto- and enol-groups
    		•  4.32416700334664 bayes_pls_golite062009
  • peptidyl-proline 4-dioxygenase activity
    		•  3.90122473218664 bayes_pls_golite062009
  • procollagen-proline 4-dioxygenase activity
    		•  3.90122473218664 bayes_pls_golite062009
  • peptidyl-proline dioxygenase activity
    		•  3.90122473218664 bayes_pls_golite062009
  • procollagen-proline dioxygenase activity
    		•  3.90122473218664 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
    		•  2.13527344103164 bayes_pls_golite062009
  • antioxidant activity
    		•  1.38472228155226 bayes_pls_golite062009
  • peroxidase activity
    		•  1.23048224324129 bayes_pls_golite062009
  • oxidoreductase activity, acting on peroxide as acceptor
    		•  1.23048224324129 bayes_pls_golite062009
  • protein binding
    		•  1.18479617596618 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.11518182894524 bayes_pls_golite062009
  • signal transducer activity
    		•  1.11518182894524 bayes_pls_golite062009
  • disulfide oxidoreductase activity
    		•  1.07184913651636 bayes_pls_golite062009
  • binding
    		•  0.828696005067827 bayes_pls_golite062009
  • catalytic activity
    		•  0.672192331361968 bayes_pls_golite062009
  • glutathione peroxidase activity
    		•  0.527635650858282 bayes_pls_golite062009
  • protein disulfide oxidoreductase activity
    		•  0.44918717550973 bayes_pls_golite062009
  • peroxiredoxin activity
    		•  0.366096607480921 bayes_pls_golite062009
  • thioredoxin peroxidase activity
    		•  0.163136748643487 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors
    		•  0.0409648030371754 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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