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Protein Overview: nhx-2

General Information:
Name(s) found: nhx-2 / CE29549 [WormBase]
Description(s) found:
Found 15 descriptions.
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  • WBGene00003730 locus:nhx-2 NA(+)\/H(+) exchanger status:Confirmed UniProt:Q09432 protein_id:CCD61472.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 627 amino acids

    Gene Ontology:
    Cellular Component: integral to membrane [IEALink to PubMed article]
    apical plasma membrane [IDALink to PubMed article]
    Biological Process: lipid storage [IMPLink to PubMed article]
    positive regulation of growth rate [IGILink to PubMed article][IMPLink to PubMed articleLink to PubMed article]
    determination of adult lifespan [IMPLink to PubMed article]
    post-embryonic body morphogenesis [IMPLink to PubMed article]
    gamete generation [IMPLink to PubMed article]
    positive regulation of multicellular organism growth [IMPLink to PubMed article]
    reproduction [IMPLink to PubMed article]
    growth [IMPLink to PubMed articleLink to PubMed article]
    regulation of pH [IEALink to PubMed article][IGILink to PubMed article][IMPLink to PubMed article]
    sodium ion transport [IEALink to PubMed article]
    regulation of pharyngeal pumping [IMPLink to PubMed article]
    nutrient import [IMPLink to PubMed article]
    nematode larval development [IMPLink to PubMed articleLink to PubMed articleLink to PubMed article]
    Molecular Function: solute:hydrogen antiporter activity [IEALink to PubMed article]
    sodium:hydrogen antiporter activity [IEALink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSYVGAECEE EEKEYPSRYP IAYFEWENVK IPMTICLWLI GASIAKIIFN LIPHLNELFP  60
   61 DSALLIMIGL IIGIIFKLIG VNKNAFFLES EVFMLYLLPP LVFDAGYFMP ARQFFDNFGS 120
  121 ILCFAMIGTS FNIVAIALSL WAISLTGLFS VETPLMHMLL FGSVAADVDP VAVIVIFEEL 180
  181 KVNEVLFIAV FGESLLNDGV AVVLYRMFLT FSEIGTENLI TSDYINGGVS FLVVAFGGIG 240
  241 IGLLFAFLTS LVTRFARDEE VKVLNSVFIL ILPYTCYLCG ELFGLSSIMA IVFCGAAMRQ 300
  301 YCRENVDPDT VKATESFIKV LSLASETVIF VFLGLSTVSS NHHWDTSFIV LTVVFCLIYR 360
  361 TLGVVVMCYF LNKYRLNKYT KVDQFIMAYG GLRGAIAYGL VVAIPDFIPG KNMFVTSCII 420
  421 VIYFTVFLQG ITLKPIAEFL QVEKKNVHSK NMIEHIYSEL IDTTMAGMED IAGFKGHHWI 480
  481 RDSWNALNNN YLRPILVNKN NMKEMDKTKL VRKYKHLVDE DAKKIARGDL NSNMVFTKAL 540
  541 IEHTRSRTNT MIDGVSSTSK IDFTKHMKEN FGVTVYDDHS TVPMTPTHLF QETTEVEYSV 600
  601 RSEINDNDGF ENDGYESDES GSFHERV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..443] FFAS03 1.04 Crystal Structure of the Glycerol-3-Phosphate Transporter from E.Coli
    2 View Details [444..627] FFAS03 1.55 C-terminal domain of PLC-beta

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • substrate-specific transmembrane transporter activity
    		•  3.29601790030287 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.37005362941394 bayes_pls_golite062009
  • transporter activity
    		•  2.27206061444828 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.08122979774613 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.76993243926717 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.49938666401349 bayes_pls_golite062009
  • binding
    		•  0.368477568387728 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.206030814887517 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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