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Protein Overview: cku-70

General Information:
Name(s) found: cku-70 / CE28984 [WormBase]
Description(s) found:
Found 13 descriptions.
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  • WBGene00000519 locus:cku-70 status:Partially_confirmed UniProt:Q9U2D2 protein_id:CAB55094.2 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 691 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEALink to PubMed article]
    DNA-dependent protein kinase-DNA ligase 4 complex [IEALink to PubMed article]
    Biological Process: determination of adult lifespan [IMPLink to PubMed article]
    double-strand break repair via nonhomologous end joining [IEALink to PubMed article]
    Molecular Function: DNA binding [IEALink to PubMed article]
    ATP-dependent DNA helicase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDETRFEDDD FEGSTANKKY TFFIIDGNPA MFETSKAGEP PEFKLALKLI LDEIVRVCCS  60
   61 RSLNNHIGVI VTSTKNSETE GLENSTLLVP MGVLGQEEVN KIKEIAEEEN LLSAVNNYGG 120
  121 DHHKSDLSNV LNYCKRVFAS CSNTRHQSVI YLTNNRNPFE RDDFLESSHF KRTKAAVTKI 180
  181 IGEGHRKTLG EFSVIMLPED GYKPQDKDEK RKEPWYDLDT EVFSTECDAA ARIRQKITAQ 240
  241 RSHATLTVNV GPGVTFDVSV FSMVMEAKPL DHSQKYTRDT EEKIVKTSGY VKKESKMELE 300
  301 STEIETQDSV LDETQKMLIR CKNFFCCENS EKNEFLEDSI RNRRDLKKSI EIGGEKIILD 360
  361 GDQYEYMNEV NSKGVDFVGF CSMSRVDRET SVVSSKIIQP NDQTTLGSTA IYRTFLDRCW 420
  421 ARQQAIVCKY QSRSKQKMRL MALVPFKKDM TLIEKRHENG EDDDDMEDKK PDLLRLEQQR 480
  481 AQADSSEWLH EGFMLVGQPF REELRDDFKR FEEQQNVLTE PSTEEQVNTM KQFVKRLTMS 540
  541 YNPSFYENPR LLSERSALCL EATGEELIER RDTLEPYYQI PKRLQRVGTE IEKIVETFAL 600
  601 NDEIKETKPK ASAGRKRKTD DDEPSTSKKA TMTIRDCIAA DKIGKFKKDE LLSMAVEHCE 660
  661 ASKSLKSKTK NDIIAVIEAY LDENPSATWN I

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run hcp-1 hcp1 IP from december2004 Cheeseman, I.M., et al. (2005)
    View Run hcp-2 hcp2 ip from december Cheeseman, I.M., et al. (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..691] PSI-BLAST 138.0 DNA binding C-terminal domain of ku70; Ku70 subunit

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  0.981851677550686 bayes_pls_golite062009
  • protein binding
    		•  0.83757188492226 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle