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Protein Overview: lag-1

General Information:
Name(s) found: lag-1 / CE28839 [WormBase]
Description(s) found:
Found 22 descriptions.
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  • WBGene00002245 locus:lag-1 status:Confirmed UniProt:G5EDU7 protein_id:CCD72375.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 673 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA][IEALink to PubMed article]
    Biological Process: positive regulation of vulval development [IMPLink to PubMed article]
    collagen and cuticulin-based cuticle attachment to epithelium [IMPLink to PubMed article]
    molting cycle, protein-based cuticle [IMPLink to PubMed article]
    regulation of cell fate specification [IMPLink to PubMed articleLink to PubMed article]
    hermaphrodite genitalia development [IMPLink to PubMed article]
    nematode larval development [IMPLink to PubMed articleLink to PubMed articleLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed article]
    oviposition [IMPLink to PubMed article]
    germ-line stem cell division [IMPLink to PubMed article]
    positive regulation of transcription from RNA polymerase II promoter [IMPLink to PubMed article]
    cell fate specification [IMPLink to PubMed article]
    Molecular Function: DNA binding [IEALink to PubMed article]
    transcription factor activity [IEALink to PubMed article]
    protein binding [IEALink to PubMed article]
    sequence-specific DNA binding [IDA]
    Notch binding [IPI]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPLAYSTHDN FYESPKTPQP TWDHVHAQFP LGEPARNLDK FIVPEAMFQS VSPLAGVAAA  60
   61 PSQIAALQQI QALMTFQMQQ NNLFPKIDTI SKSPTPELAS PSAKRMRLSP STSSHSDVAS 120
  121 TSKGTNGQDQ SKNSPTNSDP FYTIGQSTPN TSSFLDTSNS SFGAPSTVVA NPMTNYQLAF 180
  181 QAKLGSLHSL IGDSVQSLTS DRMIDFLSNK EKYECVISIF HAKVAQKSYG NEKRFFCPPP 240
  241 CIYLIGQGWK LKKDRVAQLY KTLKASAQKD AAIENDPIHE QQATELVAYI GIGSDTSERQ 300
  301 QLDFSTGKVR HPGDQRQDPN IYDYCAAKTL YISDSDKRKY FDLNAQFFYG CGMEIGGFVS 360
  361 QRIKVISKPS KKKQSMKNTD CKYLCIASGT KVALFNRLRS QTVSTRYLHV EGNAFHASST 420
  421 KWGAFTIHLF DDERGLQETD NFAVRDGFVY YGSVVKLVDS VTGIALPRLR IRKVDKQQVI 480
  481 LDASCSEEPV SQLHKCAFQM IDNELVYLCL SHDKIIQHQA TAINEHRHQI NDGAAWTIIS 540
  541 TDKAEYRFFE AMGQVANPIS PCPVVGSLEV DGHGEASRVE LHGRDFKPNL KVWFGATPVE 600
  601 TTFRSEESLH CSIPPVSQVR NEQTHWMFTN RTTGDVEVPI SLVRDDGVVY SSGLTFSYKS 660
  661 LERHGPCRIV SNY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..193] MSA 1.02297 View MSA. No confident structure predictions are available.
    2 View Details [194..673] PSI-BLAST 1000.0 Crystal Structure of CSL bound to DNA

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • DNA strand annealing activity
    		•  3.4893308969288 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.85

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle