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Protein Overview: top-3

General Information:
Name(s) found: top-3 / CE28138 [WormBase]
Description(s) found:
Found 22 descriptions.
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  • WBGene00006596 locus:top-3 DNA topoisomerase 3 status:Confirmed UniProt:O61660 protein_id:CAB60518.2 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 759 amino acids

    Gene Ontology:
    Cellular Component: chromosome [IEALink to PubMed article]
    Biological Process: gamete generation [IMPLink to PubMed article]
    DNA topological change [IEALink to PubMed article]
    DNA modification [IEALink to PubMed article]
    DNA unwinding involved in replication [IEALink to PubMed article]
    Molecular Function: nucleic acid binding [IEALink to PubMed article]
    DNA binding [IEALink to PubMed article]
    zinc ion binding [IEALink to PubMed article]
    DNA topoisomerase activity [IEALink to PubMed article]
    DNA topoisomerase type I activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKRALFVAEK NDVAKGVAAI LSNGTANRRE GRSKFNKIYT LNTELFGQQT AISVTSVSGH  60
   61 MMNFQFHENM SNWQTASMVE LFRAPVRHVV TPEMKLIEQT LREQAQRHDI LVVWTDCDRE 120
  121 GEAIGAEIVK VCRDSNRRLD IFRARFSEIT KAAITRAARN LIRLDEKTVA AVDCRSELDL 180
  181 RIGSAFTRLQ TLHLRNRFRD LLGQNDTSQV ISYGSCQFPT LGFVTDRYKM IENFVSEPFW 240
  241 KLIVEHTRES HKVEFLWDRN RLFDRDTVDI LHDECKETKE AHVEKVAKKP KSKWRPQALD 300
  301 TVELEKLGIS KLRMSAKQTM QVAEKLYSKG FISYPRTETN KFPAGLNLTP LVQQQTQSNI 360
  361 WGDFANEVLQ NGVNPRNGRK SDEAHPPIHP LKFTEKHQLQ GDDWKVYELV VRHFLACVSQ 420
  421 DAQGEETMVN LTVGTEKFHA SGLRIRDMGY LKVYVYEKWG NRLLPTYTEG ERFTDFELKI 480
  481 GDGKTQAPDF LTEADLISLM DKYGIGTDAT HAEHIEKIKT REYIGVRPDG KLIPSFLGLA 540
  541 LVDGYDDMGF AMSKPDLRAN LEIGLKEICD GRRQKQEVLD EQIGKYRAIF VESERKIGVL 600
  601 SQSLQRYLDK NNQAGGGPGG PGGGGGPPRG PGGGGGGGPT GPPAPPKPPA KPRGRPPRKS 660
  661 ISPAVKNGHD DPENDTIVTL SEVFGSMSNP KPARKPRAPR KSAAPKEQEE EEEVFCQCPE 720
  721 PMRAVTKVVQ KEGPNKGKKF YTCSLPYTSS EKCNFFKWA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..607] PSI-BLAST 1000.0 AMINO TERMINAL 67KDA DOMAIN OF ESCHERICHIA COLI DNA TOPOISOMERASE I (RESIDUES 2-590 OF MATURE PROTEIN) CLONING ARTIFACT ADDS TWO RESIDUES TO THE AMINO-TERMINUS WHICH WERE NOT OBSERVED IN THE EXPERIMENTAL ELECTRON DENSITY (GLY-2, SER-1).
    2 View Details [608..759] FFAS03 1.19 No description for 2j63A was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA topoisomerase activity
    		•  10.2798831210729 bayes_pls_golite062009
  • DNA topoisomerase type I activity
    		•  8.04585827786358 bayes_pls_golite062009
  • isomerase activity
    		•  5.61256457337998 bayes_pls_golite062009
  • DNA binding
    		•  5.20730175008144 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.95671919332271 bayes_pls_golite062009
  • binding
    		•  4.3089127577748 bayes_pls_golite062009
  • catalytic activity
    		•  1.50449367975676 bayes_pls_golite062009
  • protein binding
    		•  0.377429709958808 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle