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Protein Overview: unc-43

General Information:
Name(s) found: unc-43 / CE28053 [WormBase]
Description(s) found:
Found 17 descriptions.
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  • WBGene00006779 locus:unc-43 calcium\/calmodulin dependent protein kinase status:Partially_confirmed UniProt:O62305 protein_id:CAC42359.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 720 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: protein amino acid phosphorylation [IEALink to PubMed article]
    Molecular Function: magnesium ion binding [IEALink to PubMed article]
    ATP binding [IEALink to PubMed article]
    protein tyrosine kinase activity [IEALink to PubMed article]
    protein kinase activity [IEALink to PubMed article]
    protein serine/threonine kinase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMNASTKFSD NYDVKEELGK GAFSVVRRCV HKTTGLEFAA KIINTKKLSA RDFQKLEREA  60
   61 RICRKLQHPN IVRLHDSIQE ESFHYLVFDL VTGGELFEDI VAREFYSEAD ASHCIQQILE 120
  121 SIAYCHSNGI VHRDLKPENL LLASKAKGAA VKLADFGLAI EVNDSEAWHG FAGTPGYLSP 180
  181 EVLKKDPYSK PVDIWACGVI LYILLVGYPP FWDEDQHRLY AQIKAGAYDY PSPEWDTVTP 240
  241 EAKSLIDSML TVNPKKRITA DQALKVPWIC NRERVASAIH RQDTVDCLKK FNARRKLKAA 300
  301 ISAVKMVTRM SGVLRTSDST GSVASNGSTT HDASQVAGTS SQPTSPAAEV YPNVLLFNPQ 360
  361 KFPRNCVHPF TTHPYYSPKE SSKKKLFFTL LFEVCPHTSR SHILLRDNTK NIYHPYHCFT 420
  421 NKMSNYERAA PSSHGSSTTK KIANAIADLV IRRSSPSIRR KTEADVHNSN RNRKVSAPAN 480
  481 LQHALVPVID VVVATGALAS SSVDNLSAST SSDLGRNLLN KKEQGPPSTI KESSESSQTI 540
  541 DDNDSEKGGG QLKHENTVVR ADGATGIVSS SNSSTASKSS STNLSAQKQD IVRVTQTLLD 600
  601 AISCKDFETY TRLCDTSMTC FEPEALGNLI EGIEFHRFYF DGNRKNQVHT TMLNPNVHII 660
  661 GEDAACVAYV KLTQFLDRNG EAHTRQSQES RVWSKKQGRW VCVHVHRSTQ PSTNTTVSEF 720
  721

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run hcp-2 hcp2 ip from december Cheeseman, I.M., et al. (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..341] PSI-BLAST 89.30103 Crystal Structure of the Auto-Inhibited Kinase Domain of Calcium/Calmodulin Activated Kinase II
    2 View Details [342..586] deduced N/A No confident structure predictions are available.
    3 View Details [587..720] PSI-BLAST 55.154902 The Association Domain of C. elegans CaMKII


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.77

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle