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View Structure Prediction Details

Protein: unc-43
Organism: Caenorhabditis elegans
Length: 720 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for unc-43.

Description E-value Query
Range
Subject
Range
gi|73952997 - gi|73952997|ref|XP_863379.1| PREDICTED: similar to Calcium/calmodulin-dependent protein kinase type ...
562.0 [0..6] [714..8]

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Predicted Domain #1
Region A:
Residues: [1-341]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMNASTKFSD NYDVKEELGK GAFSVVRRCV HKTTGLEFAA KIINTKKLSA RDFQKLEREA  60
   61 RICRKLQHPN IVRLHDSIQE ESFHYLVFDL VTGGELFEDI VAREFYSEAD ASHCIQQILE 120
  121 SIAYCHSNGI VHRDLKPENL LLASKAKGAA VKLADFGLAI EVNDSEAWHG FAGTPGYLSP 180
  181 EVLKKDPYSK PVDIWACGVI LYILLVGYPP FWDEDQHRLY AQIKAGAYDY PSPEWDTVTP 240
  241 EAKSLIDSML TVNPKKRITA DQALKVPWIC NRERVASAIH RQDTVDCLKK FNARRKLKAA 300
  301 ISAVKMVTRM SGVLRTSDST GSVASNGSTT HDASQVAGTS S

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 89.30103
Match: 2bdwA
Description: Crystal Structure of the Auto-Inhibited Kinase Domain of Calcium/Calmodulin Activated Kinase II
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [342-586]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QPTSPAAEVY PNVLLFNPQK FPRNCVHPFT THPYYSPKES SKKKLFFTLL FEVCPHTSRS  60
   61 HILLRDNTKN IYHPYHCFTN KMSNYERAAP SSHGSSTTKK IANAIADLVI RRSSPSIRRK 120
  121 TEADVHNSNR NRKVSAPANL QHALVPVIDV VVATGALASS SVDNLSASTS SDLGRNLLNK 180
  181 KEQGPPSTIK ESSESSQTID DNDSEKGGGQ LKHENTVVRA DGATGIVSSS NSSTASKSSS 240
  241 TNLSA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [587-720]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QKQDIVRVTQ TLLDAISCKD FETYTRLCDT SMTCFEPEAL GNLIEGIEFH RFYFDGNRKN  60
   61 QVHTTMLNPN VHIIGEDAAC VAYVKLTQFL DRNGEAHTRQ SQESRVWSKK QGRWVCVHVH 120
  121 RSTQPSTNTT VSEF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 55.154902
Match: 2f86B
Description: The Association Domain of C. elegans CaMKII
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle