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Protein Overview: daf-12

General Information:
Name(s) found: daf-12 / CE27585 [WormBase]
Description(s) found:
Found 20 descriptions.
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  • WBGene00000908 locus:daf-12 status:Confirmed UniProt:G5EG55 protein_id:CAC42283.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 694 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEALink to PubMed article]
    Biological Process: negative regulation of multicellular organism growth [IMPLink to PubMed articleLink to PubMed article]
    regulation of development, heterochronic [IMPLink to PubMed article]
    regulation of transcription, DNA-dependent [IEALink to PubMed article]
    Molecular Function: DNA binding [IEALink to PubMed article]
    transcription factor activity [IEALink to PubMed article]
    zinc ion binding [IEALink to PubMed article]
    steroid hormone receptor activity [IEALink to PubMed article]
    sequence-specific DNA binding [IEALink to PubMed article]
    steroid binding [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTPDDPVIH SPPSIGAAPG MNGYHGSGVK LEESSGACGS PDDGLLDSSE ESRRRQKTCR  60
   61 VCGDHATGYN FNVITCESCK AFFRRNALRP KEFKCPYSED CEINSVSRRF CQKCRLRKCF 120
  121 TVGMKKEWIL NEEQLRRRKN SRLNNTGTCN KRSQPGNQQS PQGPNQQPHL SPHHPGVAIY 180
  181 PPQPQRPLTI NPMDNQMMHH MQANRPNAMP QLISPPGAQP YPLTSPVGSS ASDSPPNRSL 240
  241 TMMHNGEKSP DGYDPNIMAH RAPPPSFNNR PKMDSGQVVL STEEYKQLLS RIPGAQVPGL 300
  301 MNEEEPINKR AAYNCNGHPM PAETTPPYSA PMSDMSLSRH NSTSSGTEKN HMTHSTVSAI 360
  361 PGNSAQNHFD IASFGMGIVT ATGGGDAAEE MYKRMNMFYE NCIQSALDSP ENQEPKPQEA 420
  421 MIPKEEYMTP THGFQYQSDP YQVPPAERNI NYQLNAAELK ALDAVREAFY GMDDPMEQGR 480
  481 QMQSFLKANK TPADIMNIMD VTMRRFVKVA KGVPAFREVS QEGKFSLLKG GMIEMLTVRG 540
  541 VTRYDASTNS FKTPTIKGQN VSVNVDDMFA KLNANAQAQK AKCLEFFGFF DEEIKKNELA 600
  601 VYLVMLAVLF SVRSDPPMNE NDVRIVTERH NHFMSLLNRY LESLFGEQAR RIFERIPKAL 660
  661 GLLNEIARNA GMLFMGTVRS GEAEELPGEF FKIK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..215] PSI-BLAST 27.39794 Human Liver Receptor Homologue DNA-Binding Domain (hLRH-1 DBD) in Complex with dsDNA from the hCYP7A1 Promoter
    2 View Details [216..363] deduced N/A No confident structure predictions are available.
    3 View Details [364..694] PSI-BLAST 43.0 hemipteran ecdysone receptor ligand-binding domain complexed with ponasterone A


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle