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View Structure Prediction Details

Protein: daf-12
Organism: Caenorhabditis elegans
Length: 694 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for daf-12.

Description E-value Query
Range
Subject
Range
daf-12 - status:Confirmed UniProt:Q9XZD4 protein_id:CAC42284.1
338.0 [0..1] [694..60]

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Predicted Domain #1
Region A:
Residues: [1-215]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTPDDPVIH SPPSIGAAPG MNGYHGSGVK LEESSGACGS PDDGLLDSSE ESRRRQKTCR  60
   61 VCGDHATGYN FNVITCESCK AFFRRNALRP KEFKCPYSED CEINSVSRRF CQKCRLRKCF 120
  121 TVGMKKEWIL NEEQLRRRKN SRLNNTGTCN KRSQPGNQQS PQGPNQQPHL SPHHPGVAIY 180
  181 PPQPQRPLTI NPMDNQMMHH MQANRPNAMP QLISP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 27.39794
Match: 2a66A
Description: Human Liver Receptor Homologue DNA-Binding Domain (hLRH-1 DBD) in Complex with dsDNA from the hCYP7A1 Promoter
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [216-363]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PGAQPYPLTS PVGSSASDSP PNRSLTMMHN GEKSPDGYDP NIMAHRAPPP SFNNRPKMDS  60
   61 GQVVLSTEEY KQLLSRIPGA QVPGLMNEEE PINKRAAYNC NGHPMPAETT PPYSAPMSDM 120
  121 SLSRHNSTSS GTEKNHMTHS TVSAIPGN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [364-694]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SAQNHFDIAS FGMGIVTATG GGDAAEEMYK RMNMFYENCI QSALDSPENQ EPKPQEAMIP  60
   61 KEEYMTPTHG FQYQSDPYQV PPAERNINYQ LNAAELKALD AVREAFYGMD DPMEQGRQMQ 120
  121 SFLKANKTPA DIMNIMDVTM RRFVKVAKGV PAFREVSQEG KFSLLKGGMI EMLTVRGVTR 180
  181 YDASTNSFKT PTIKGQNVSV NVDDMFAKLN ANAQAQKAKC LEFFGFFDEE IKKNELAVYL 240
  241 VMLAVLFSVR SDPPMNENDV RIVTERHNHF MSLLNRYLES LFGEQARRIF ERIPKALGLL 300
  301 NEIARNAGML FMGTVRSGEA EELPGEFFKI K

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 43.0
Match: 1z5xE
Description: hemipteran ecdysone receptor ligand-binding domain complexed with ponasterone A
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle